pla2g4a
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  • Official Full Name
  • phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Background
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms
  • PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
Cat.#:PLA2G4A-12895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, His-tagged
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Cat.#:PLA2G4A-1752HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, GST-tagged
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Cat.#:PLA2G4A-30736THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLA2G4A
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Cat.#:PLA2G4A-42HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G4A protein, FLAG/His-tagged
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Cat.#:PLA2G4A-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G4A protein, MYC/DDK-tagged
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Cat.#:PLA2G4A-752HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-12894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein
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Cat.#:PLA2G4A-6974CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G4A
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Cat.#:PLA2G4A-3141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4A 293 Cell Lysate
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Involved Pathway

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
CHKB; AGPAT2; PEMT; LPCAT1; ETNPPL; GPD1C; PPAP2C; PLA2G2A; PLA2G4C; AGPAT9
Ether lipid metabolism
ENPP6; PLA2G5; PPAP2D; PLA2G4C; PLA2G4B; PLD4; GAL3ST1A; PPAP2C; CEPT1; PLA2G7
Arachidonic acid metabolism
FAAH2A; CBR3; GPX7; PTGDSA; CYP2B6; CYP4A10; GPX2; PLA2G10; PTGDS; PLA2G4AA
Linoleic acid metabolism
CYP2P10; CYP3A65; PLA2G4AA; CYP3A41A; PLA2G2A; ALOX15; CYP2C37; PLA2G12B; CYP2C70; CYP2C55
alpha-Linolenic acid metabolism
PLA2G2A; PLA2G10; PLA2G5; PLA2G4A; PLA2G4D; ACAA1; ACOX1; PLA2G12B; PLA2G1B; PLA2G12A
Metabolic pathways
OGDH; GRHPR; HMGCLL1; NME5; HYAL2; INPP5B; PTGES; XDH; ACLY; ST3GAL5
MAPK signaling pathway
MAPK8B; ACVR1C; TNFRSF1A; CDC42L2; MAPK12; MAP2K2A; MAX; CACNA2D2; FGF18A; MAP3K3
Ras signaling pathway
INS1; PAK6; NRAS; PLA2G1B; MAP2K2; FGF5; INSR; REL; FGF16; ABL2
Phospholipase D signaling pathway
PLA2G4A; PLA2G4D; RHOA; FCER1G; PDGFC; AKT1; PLA2G4C; SHC2; MAP2K2; RALB
Vascular smooth muscle contraction
ARHGEF11; PLA2G4C; MAP2K2A; PPP1R12B; PRKG1; ROCK2A; ADRA1BB; PRKCG; PLA2G3; GNAS
VEGF signaling pathway
MAPKAPK2; PXNA; HRASB; PTGS2A; RAC1B; PPP3R2; VEGFA; MAPK14A; RAF1A; AKT1
Platelet activation
GNAI2; PLCB3; MYLK4; PPP1CC; PIK3R2; F2RL3; PLA2G4F; SRC; GUCY1A3; RAP1A
Fc epsilon RI signaling pathway
MAPK10; SYK; AKT2; RAF1; MAPK3; RAC1; NRAS; PLA2G4B; IL5; PIK3R2
Fc gamma R-mediated phagocytosis
PLA2G4F; BIN1; CFL2; MARCKS; MAPK3; PAK1; AKT1; VASP; SYK; ASAP3
Glutamatergic synapse
GRIK5; SLC17A7; GNAI2; GNG10; TRPC1; ADRBK2; PPP3CC; GNB3; GRM7; MAPK1
Serotonergic synapse
ITPR3; HTR2A; KCNN2; CYP2D26; PLCB3; GNAI2; GNG10; ALOX12; CYP2C70; GABRB1
Long-term depression
PLCB1; NRAS; MAPK3; GNAS; BRAF; GUCY1B3; GNAI1; PRKCG; PLA2G4F; GNA12
Inflammatory mediator regulation of TRP channels
GNAS; MAPK12; CALM4; PRKACA; CALML3; PIK3R3; ASIC4; ASIC5; PRKCQ; TRPM8
GnRH signaling pathway
MAPK1; PLD1A; PRKACG; PRKACB; ADCY2B; GNA15.1; PLA2G4A; GNA11B; MAP3K4; EGFRA
Ovarian steroidogenesis
LHCGR; HSD3B5; PRKACG; AKR1C3; PTGS2; FSHR; PLA2G4F; Adcy4; HSD3B1; PRKACA
Oxytocin signaling pathway
GNAO1; RCAN1; PPP1R12B; CACNB2; KRAS; PPP1CC; ACTG1; CACNG8; MYL6; CACNB1
Choline metabolism in cancer
PDGFA; PIK3R3; PCYT1A; Pdgfa&Pdgfb; PIK3CG; PLA2G4C; WASF2; PIK3R5; PDGFRB; SLC5A7

Protein Function

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein EHD1A; PCDH2AB11; DSG1C; RCN3; TC2N; KIAA0494; SLC24A5; ADAM8; AKR1C1; SYT10
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G3; PLA2G4B; PLA2G1B; PLA2G5; PLA2G4A; PLA2G12A; PLA2G4F; PLA2G2A
Function calcium-dependent phospholipid binding
Related Protein SYT7; SYT9; SYT11A; SYT11; C2CD4B; ANXA13L; ANXA4; ANXA1B; ANXA2B; ANXA13
Function lysophospholipase activity
Related Protein PLA2G15; PLA2G4B; LYPLA1; LYPLAL1; PLA2G4A; Cel; PNPLA8; LGALS13; PLA2G4F; PNPLA7A
Function phospholipase A2 activity
Related Protein PNPLA3; RARRES3; PLA2G4D; PLA2G4AA; PLA2G4A; PLA2G6; OC90; PLB1; PLA2G2A; PLA2G10

Interacting Protein

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e