pla2g4a
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  • Official Full Name
  • phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Background
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms
  • PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
Cat.#:PLA2G4A-12895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, His-tagged
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Cat.#:PLA2G4A-1752HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, GST-tagged
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Cat.#:PLA2G4A-30736THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLA2G4A
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Cat.#:PLA2G4A-42HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G4A protein, FLAG/His-tagged
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Cat.#:PLA2G4A-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G4A protein, MYC/DDK-tagged
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Cat.#:PLA2G4A-752HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-12894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein
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Cat.#:PLA2G4A-6974CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G4A
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Cat.#:PLA2G4A-3141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4A 293 Cell Lysate
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Involved Pathway

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
CHKB; CHKA; PLA2G16; PNPLA7; GNPAT; DGKQ; PLA2G6; DGKZ; PTDSS1; PLA2G3
Ether lipid metabolism
PPAP2C; LPCAT4; PLA2G12A; PLA2G4C; PLA2G16; PPAP2B; CEPT1B; PPAP2CB; PLA2G7; PLA2G1B
Arachidonic acid metabolism
PTGS2B; CYP2P7; PLA2G6; AKR1C21; CYP2P9; CBR1L; GPX8; CYP2C54; CYP2C38; CYP2B6
Linoleic acid metabolism
CYP2C54; PLA2G12B; PLA2G6; PLA2G2F; CYP2C38; PLA2G4AA; CYP2C9; CYP2J6; PLB1; ALOX15
alpha-Linolenic acid metabolism
PLA2G2E; PLA2G6; PLA2G2A; PLA2G5; PLA2G4C; PLA2G4F; PLA2G12B; PLA2G4A; ACAA1; PLA2G12A
Metabolic pathways
KL; MUT; PAFAH2; GALT; ATP6V1AA; AGPAT3; QDPRA; ALDH9A1; MTMR3; ALPL
MAPK signaling pathway
FGF8A; MAPK4; AKT2; RAC3A; LRRK2; MKNK2A; KCNA3; BDNF; MAPK9; MAPK7
Ras signaling pathway
NFKB1; NGFR; SOS1; RAC2; PAK7; FGF13; FLT4; FGF19; ELK1; FGF10
Phospholipase D signaling pathway
PIK3R2; LPAR5; GRB2; GRM6; Pdgfa&Pdgfb; ARF6; AGTR1A; AVPR1B; GRM3; MTOR
Vascular smooth muscle contraction
ADORA2AB; PLA2G2F; MLCK2; GNAS; PLA2G4A; PPP1R12A; GNA11B; RAF1; PLA2G6; ADCY1A
VEGF signaling pathway
PLA2G4A; PIK3CG; CDC42; SRC; PIK3R3A; AKT1; PPP3CA; RAF1B; RAC1B; PTGS2
Platelet activation
PLCB4; MYLK3; FERMT3; TBXA2R; PLA2G4A; PLCB2; PIK3R2; MAPK3; MYL12B; SYK
Fc epsilon RI signaling pathway
MAPK3; PDPK1; RAF1; LYN; IL13; BTK; PLA2G4B; GAB2; PLCG1; MAPK8
Fc gamma R-mediated phagocytosis
MAPK1; WASF1; MARCKSL1; MARCKS; PIK3CG; PIP5K1B; INPPL1; PLD1; AKT1; VASP
Glutamatergic synapse
GRIA1; GRIA2; GRIN2C; PLCB4; GRIN2D; GRIA3; GRIK5; GNG4; PLCB1; GRIK1
Serotonergic synapse
CYP2C50; GNG2; CYP2C54; HTR1E; GABRB1; GNB1; PRKACG; CYP2J6; ITPR3; GNAI1
Long-term depression
PRKCA; GRM1; NRAS; CRHR1; NOS1; PLCB4; LYN; RYR1; GNAI2; GNAQ
Inflammatory mediator regulation of TRP channels
Adcy4; CYP2C70; CAMK2D; IL1B; MAPK13; PLCG1; CALM4; CYP2J2; ACCN3; MAP2K6
GnRH signaling pathway
PLA2G4A; CDC42L; GNA11A; PRKACBA; PLD1; GNRHR1; PLA2G4F; ITPR1; GNRH2; RAF1B
Ovarian steroidogenesis
CYP2J5; ALOX5; GDF9; HSD17B2; HSD3B5; INSR; GNAS; HSD3B1; PLA2G4A; HSD3B2
Oxytocin signaling pathway
MYL6B; PLA2G4C; MAP2K1; KCNJ14; KRAS; MYLK; PPP1CC; GUCY1A3; ELK1; EEF2K
Choline metabolism in cancer
PIK3CB; MAP2K1; PLA2G4F; PPAP2B; WAS; PIK3R3; SP1; PIK3CG; PIK3R5; PRKCB

Protein Function

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein S100Z; SPARCL1; F7I; DST; S100A2; PCDH1A6; FKBP7; CDH20; S100A10B; RPH3A
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G4B; PLA2G2A; PLA2G1B; PLA2G5; PLA2G3; PLA2G12A; PLA2G4A; PLA2G4F
Function calcium-dependent phospholipid binding
Related Protein C2CD4B; SYT7; CPNE3; ANXA1; ANXA3B; ANXA3; C2CD4A; ANXA2; ESYT2; SYT5
Function lysophospholipase activity
Related Protein PNPLA7; Cel; LYPLAL1; PLB1; LYPLA1; PLA2G15; PLA2G4F; MGLL; PLA2G4A; LGALS13
Function phospholipase A2 activity
Related Protein PLA2G12B; PLA2G2F; ABHD3; PLA2G1B; PLA2G6; PLB1; PLA2G4A; LCAT; PLA2G16; PLA2G2E

Interacting Protein

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e