pla2g4a
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  • Official Full Name
  • phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Background
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms
  • PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
Cat.#:PLA2G4A-12895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, His-tagged
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Cat.#:PLA2G4A-1752HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, GST-tagged
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Cat.#:PLA2G4A-30736THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLA2G4A
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Cat.#:PLA2G4A-42HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G4A protein, FLAG/His-tagged
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Cat.#:PLA2G4A-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G4A protein, MYC/DDK-tagged
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Cat.#:PLA2G4A-752HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-12894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein
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Cat.#:PLA2G4A-6974CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G4A
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Cat.#:PLA2G4A-3141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4A 293 Cell Lysate
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Involved Pathway

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
PLA2G2A; CHAT; DGKB; STIL; PLA2G4C; AGPAT9L; GPD1L; AGXT2L1; PLA2G16; GPCPD1
Ether lipid metabolism
PAFAH1B2; ENPP2; PLA2G4B; PLD1A; PAFAH1B3; PLD2; LPCAT1; GAL3ST1; LPCAT4; PLD3
Arachidonic acid metabolism
CYP2C37; GPX1; PTGDSB; PLA2G2A; PLA2G3; CYP4A14; GGT1; CYP4F18; CYP2B6; GPX3
Linoleic acid metabolism
CYP2C38; CYP3A25; PLB1; CYP2J5; PLA2G2D; PLA2G12B; CYP2P8; CYP2C9; CYP2P9; PLA2G2A
alpha-Linolenic acid metabolism
PLA2G4A; PLA2G4AA; PLA2G10; ACAA1A; FADS2; PLA2G12A; PLA2G4C; PLA2G3; ACAA1; PLA2G2D
Metabolic pathways
POLR3G; ACSM3; NDUFB5; ALOX12; LTA4H; LIPF; ALG13; UQCRB; CYP2C70; GOT2B
MAPK signaling pathway
PDGFRB; MAP4K2; HSPA1A; RAP1AB; FGF2; MAP2K7; MAP3K12; FGF3; MAP2K2B; CACNA2D3
Ras signaling pathway
GNG12; SHC1; RASA3; HGF; ABL2; RGL1; FGF16; PLCG2; Fgf15; NGF
Phospholipase D signaling pathway
PIK3CB; CXCR1; PIP5K1C; AVPR2; PIP5K1A; INSR; PIK3R2; PLD2; FYN; PIK3R3
Vascular smooth muscle contraction
PRKCD; NPR1A; ROCK2; PRKCG; ARHGEF1; PPP1R12B; ITPR3; PRKACA; CALM2A; ITPR1
VEGF signaling pathway
PLA2G4D; VEGFAB; PTK2AB; MAPKAPK3; HRASB; NOS3; HRAS; AKT2; RAF1B; NRAS
Platelet activation
PIK3R3; GNAI2; GNAQ; PRKACG; PTGIR; MAPK11; PRKCI; BTK; F2RL3; PIK3R1
Fc epsilon RI signaling pathway
INPP5D; TNF; PLCG1; FYN; MAP2K3; RAC2; LAT; IL4; PLCG2; PIK3CB
Fc gamma R-mediated phagocytosis
PPAP2B; BIN1; WASL; PIP5K1B; LAT; SYK; WASF2; FCGR1A; AMPH; ASAP3
Glutamatergic synapse
GRM5; GRIN2A; GNGT1; SLC38A2; GRIN3B; GNAI3; GRIK1; ITPR1; GLS2; PLCB4
Serotonergic synapse
PRKCG; ALOX8; RAF1; CYP2D10; CYP2C70; APP; GNG2; CYP4X1; ALOX12B; CYP2C39
Long-term depression
PLCB3; PRKCA; PPP2R1B; HRAS; GRIA1; PPP2R1A; CRHR1; MAP2K1; GNAI3; ITPR1
Inflammatory mediator regulation of TRP channels
MAPK8; GNAS; IGF1; ASIC2; TRPV3; CALML5; Adcy4; ACCN3; CAMK2A; CYP2C37
GnRH signaling pathway
MAPK7; MMP14; CALML3; GNAS; CALM4; CAMK2D2; CGNRH-R; ATF4; CACNA1D; MAP2K2B
Ovarian steroidogenesis
PRKACB; IGF1; PLA2G4A; IGF1R; LHB; PLA2G4D; HSD3B4; GDF9; AKR1C3; GNAS
Oxytocin signaling pathway
CACNG8; PIK3CA; CAMKK2; TRPM2; PLCB1; GNAI3; PTGS2; PIK3CB; PRKAG3; PPP1R12A
Choline metabolism in cancer
WASF1; SP1; GRB2; PDGFC; PRKCG; MAPK3; SOS1; MTOR; PIK3CD; DGKD

Protein Function

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein S100A9; VSNL1; BGLAP-RS1; CD97; RPH3AL; CD69; ASPH; PCDHB14; CDH13; CABP2
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G1B; PLA2G4B; PLA2G2A; PLA2G3; PLA2G4F; PLA2G5; PLA2G4A; PLA2G12A
Function calcium-dependent phospholipid binding
Related Protein ANXA1; AP1S2; ANXA3; SYT7B; SYT1A; ANXA9; SYT12; TC2N; ANXA4; SYTL3
Function lysophospholipase activity
Related Protein PLA2G4B; LYPLA1; LGALS13; ENPP2; PLA2G4A; PLA2G4F; ASPG; MGLL; PNPLA8; PLA2G15
Function phospholipase A2 activity
Related Protein PLA2G2E; PLA2G6; PLA2G2F; RARRES3; PLB1; OC90; PLA2G12B; PLA2G4D; PLA2G10; PLA2G2D

Interacting Protein

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e