pla2g4a
Share
  • Official Full Name
  • phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Background
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms
  • PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
Cat.#:PLA2G4A-12895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein, His-tagged
+Inquiry
Cat.#:PLA2G4A-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, His-tagged
+Inquiry
Cat.#:PLA2G4A-1752HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, GST-tagged
+Inquiry
Cat.#:PLA2G4A-30736THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLA2G4A
+Inquiry
Cat.#:PLA2G4A-42HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G4A protein, FLAG/His-tagged
+Inquiry
Cat.#:PLA2G4A-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G4A protein, MYC/DDK-tagged
+Inquiry
Cat.#:PLA2G4A-752HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human PLA2G4A Protein, His-tagged
+Inquiry
Cat.#:PLA2G4A-12894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein
+Inquiry
Cat.#:PLA2G4A-6974CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G4A
+Inquiry
Cat.#:PLA2G4A-3141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4A 293 Cell Lysate
+Inquiry

Involved Pathway

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
PGS1; AGPAT2; MBOAT7; ACHE; PLA2G2E; PLA2G4C; PNPLA6; GPD1L; ETNK2; PNPLA7
Ether lipid metabolism
LPCAT1; PPAP2D; PLA2G4B; LPCAT2; CEPT1; PPAP2CB; EPT1; ENPP6; PLD1; GAL3ST1
Arachidonic acid metabolism
PLA2G4C; GPX1A; PLA2G4B; ALOX15; ALOX12B; CYP2J6; ALOX5AP; ALOX5B.2; CBR1L; LTA4H
Linoleic acid metabolism
PLB1; PLA2G5; CYP2P9; CYP2C54; CYP2J6; PLA2G4F; CYP2P6; CYP2C38; ALOX15; CYP2P7
alpha-Linolenic acid metabolism
PLA2G3; PLA2G4C; PLA2G12B; PLA2G12A; PLA2G2A; ACAA1A; FADS2; ACAA1; PLA2G2F; PLA2G2E
Metabolic pathways
NAT8L; IDH3G; PDHA1B; POLR2L; GGT5A; POLR2I; PNLIPRP1; CSGALNACT2; HK1; mt-Atp8
MAPK signaling pathway
MAP3K11; CACNA1D; DUSP8A; CACNB4A; CACNA1H; MAP4K4; FOS; CACNA1SB; RRAS2; MAP2K7
Ras signaling pathway
SHC4; KRAS; GNG7; PRKCG; RGL1; PLCE1; PLD1; PIK3R5; IGF1R; GNGT1
Phospholipase D signaling pathway
PLCB4; PIK3CA; PLA2G4C; CYTH1; PLA2G4D; SOS1; CXCR1; MAP2K1; PPAP2A; MTOR
Vascular smooth muscle contraction
CALML3; MAP2K1; PRKCD; MAP2K2A; NPR2; MYL12.1; ITPR1; ADCY2B; PLA2G5; PLA2G2A
VEGF signaling pathway
CDC42L; PXN; PTGS2B; NFATC2; PPP3CA; HRASA; PIK3R3A; AKT2L; SRC; PIK3CD
Platelet activation
MAPK11; ITPR1; GNAI2; ACTB; MYL12A; TBXA2R; PPP1CA; PLCG2; ITGB3; PPP1R12A
Fc epsilon RI signaling pathway
PIK3R1; MAP2K6; RAC1; GRB2; MAPK11; LCP2; VAV1; MAPK12; PRKCA; GM-CSF
Fc gamma R-mediated phagocytosis
PPAP2A; PRKCA; WASF2; VASP; RPS6KB2; PLA2G4D; FCGR3A; PIK3R5; GSN; PLCG2
Glutamatergic synapse
GNG11; GRIK2; GNAS; GRIN2C; GNG7; HOMER3; GLS2; SLC17A6; GNB1; SLC1A2
Serotonergic synapse
GNAQ; SLC18A2; PLA2G4F; KRAS; MAOB; CYP2C50; PTGS2; CYP2J6; CYP2C55; PLCB3
Long-term depression
MAP2K1; GNA13; GNAQ; PRKG2; NOS1; GNAI2; PRKCA; ARAF; IGF1; GUCY1B3
Inflammatory mediator regulation of TRP channels
CYP2C50; F2RL1; MAPK10; PRKACB; ASIC4; PRKCB; PRKACA; PRKACG; TRPM8; SRC
GnRH signaling pathway
HRAS; MAP3K3; MAPK8B; CALML5; CACNA1DA; GNRHR; PRKACAB; ADCY1A; MMP2; ITPR3
Ovarian steroidogenesis
HSD3B2; PLA2G4A; IGF1; GNAS; LDLR; IGF1R; PRKACG; PLA2G4D; ALOX5; HSD17B7
Oxytocin signaling pathway
EEF2K; CACNB3; CAMK1D; CACNA2D2; CAMK1; CALM4; CACNG1; PRKAB2; ITPR1; PRKAG1
Choline metabolism in cancer
PLD1; RPS6KB1; PLA2G4F; RAC2; PDGFRA; WASF2; TSC2; DGKE; RHEB; GPCPD1

Protein Function

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CELSR1; PCDH2G16; PCDH11Y; CDH2; MMP8; PCDH2AB10; PCDHGB6; PCDH1G22; PCDH2G10; CABP5B
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G12A; PLA2G4F; PLA2G1B; PLA2G5; PLA2G2A; PLA2G3; PLA2G4A; PLA2G4B
Function calcium-dependent phospholipid binding
Related Protein SYTL4; SYT11; SYT2; SYT9B; ANXA2A; ANXA11A; SYT15; SYTL2; SYT1; SYT10
Function lysophospholipase activity
Related Protein PNPLA7A; PNPLA6; PLA2G15; PNPLA7; PLB1; LYPLAL1; PLA2G4B; PNPLA8; PLA2G4A; Cel
Function phospholipase A2 activity
Related Protein ABHD3; PLA2G4AA; PLA2G2D; PLB1; PLA2G1B; PLA2G6; PLA2G2E; RARRES3; PLA2G16; PLA2G10

Interacting Protein

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e