pla2g4a
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  • Official Full Name
  • phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Background
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms
  • PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
Cat.#:PLA2G4A-12895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, His-tagged
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Cat.#:PLA2G4A-1752HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, GST-tagged
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Cat.#:PLA2G4A-30736THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLA2G4A
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Cat.#:PLA2G4A-42HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G4A protein, FLAG/His-tagged
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Cat.#:PLA2G4A-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G4A protein, MYC/DDK-tagged
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Cat.#:PLA2G4A-752HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human PLA2G4A Protein, His-tagged
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Cat.#:PLA2G4A-12894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein
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Cat.#:PLA2G4A-6974CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G4A
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Cat.#:PLA2G4A-3141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4A 293 Cell Lysate
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Involved Pathway

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
GPCPD1; LYPLA1; PLA2G4AA; ACHE; PLA2G12B; CEPT1B; PTDSS1; PLA2G2A; LPCAT1; CHATA
Ether lipid metabolism
PLA2G2D; CEPT1B; EPT1; PAFAH1B1; PLA2G5; PLD4; GAL3ST1A; CHPT1; PLA2G12A; PAFAH1B1B
Arachidonic acid metabolism
CYP2AD6; PLA2G2D; DPEP2; GPX1; FAAH2B; GGT5A; CYP2AD3; CYP2J5; GPX8; PLA2G3
Linoleic acid metabolism
PLA2G12A; PLA2G2A; PLA2G6; CYP2C45; CYP3A41B; CYP3A65; CYP2P9; CYP2J5; PLA2G2F; CYP3A25
alpha-Linolenic acid metabolism
PLA2G4C; PLA2G3; PLA2G12A; ACOX3; PLA2G1B; PLA2G4F; PLA2G4AA; ACAA1; ACOX1; PLA2G2E
Metabolic pathways
CYP11C1; PIGF; GSS; CBR3; FBP2; SCLY; TALDO1; ATP6V0C; UROS; ALG5
MAPK signaling pathway
MAPK12B; IL1A; FLNB; CACNG1A; MAX; ATF4; SRFA; RASGRF2; GRB2A; MEF2CB
Ras signaling pathway
EFNA4; ANGPT2; FGF5; NFKB1; RASSF5; MAP2K1; NGFR; INS; RASSF1; PRKACG
Phospholipase D signaling pathway
PIK3CD; PIK3R3; PLCG1; PTK2B; AVPR2; PLA2G4D; LPAR6; GRM6; PLD2; AGPAT3
Vascular smooth muscle contraction
PRKACG; MLCK2; RHOA; CALML3; EDNRAA; GUCY1A3; ROCK2; RAF1B; ROCK1; CALM3
VEGF signaling pathway
RAC3B; BAD; PTK2; PIK3CB; PRKCA; NRAS; PPP3R1B; PRKCB; PIK3CA; PPP3R1
Platelet activation
ITGA2B; COL27A1; GP5; ARHGEF1; RHOA; MAPK13; TBXA2R; GNAS; GP9; SYK
Fc epsilon RI signaling pathway
MAPK11; KRAS; IL5; FCER1G; PRKCA; RAC3; PIK3R2; IL3; PLA2G4B; MAP2K2
Fc gamma R-mediated phagocytosis
PLA2G4F; INPPL1; PIK3R3; PPAP2C; WASF2; MAP2K1; RAC1; VASP; PPAP2B; PRKCA
Glutamatergic synapse
GRIN3A; MAPK1; GNB1; SLC1A2; GNG3; GRIN2A; SLC1A7; PPP3CB; GNAI3; SLC38A2
Serotonergic synapse
GNG2; GABRB2; KRAS; MAPK1; PRKCA; CYP2J6; PRKACA; GNG8; GNG13; HTR1A
Long-term depression
MAPK3; PRKCG; PLA2G4F; GNAZ; RAF1; PLCB1; GNAI2; PPP1R17; PLA2G4D; GUCY1B3
Inflammatory mediator regulation of TRP channels
IGF1; CYP2C39; PRKACG; PPP1CA; HTR2A; PRKCB; ALOX12; PLCB4; PLCB2; HTR2C
GnRH signaling pathway
MAP3K4; MMP14A; PLCB2; LHB; MAPK3; CALM4; GNA11B; MAP2K4B; CALM3B; CGNRH-R
Ovarian steroidogenesis
IGF1R; LHCGR; PLA2G4A; BMP6; PRKACG; HSD3B5; PLA2G4F; CYP2J6; HSD17B7; ALOX5
Oxytocin signaling pathway
PLCB1; CAMKK2; CCND1; PIK3CG; CAMK1D; PIK3R5; ELK1; PLA2G4F; NRAS; PRKAB1
Choline metabolism in cancer
WASF3; SLC22A1; RAC3; LYPLA1; MAPK10; WASL; NRAS; PDPK1; PLA2G4D; PPAP2C

Protein Function

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PCDH2AB9; CANX; DGKB; CABP2A; S100A6; RHOT1; PON1; EFCAB7; MYL5; SYT17
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G4B; PLA2G1B; PLA2G5; PLA2G4F; PLA2G3; PLA2G12A; PLA2G2A; PLA2G4A
Function calcium-dependent phospholipid binding
Related Protein ANXA2B; ANXA1C; ANXA13L; ANXA3A; CCDC167; SYT9; SYT5; ANXA6; SYT11; SYTL3
Function lysophospholipase activity
Related Protein LYPLA1; PLA2G4A; Cel; LYPLAL1; ENPP2; PLB1; PLA2G15; LGALS13; PNPLA7A; ASPG
Function phospholipase A2 activity
Related Protein PNPLA3; PLA2G4AA; PRDX6; PLA2G4D; PLA2G12B; LCAT; PLA2G2F; PLA2G4A; OC90; PLB1

Interacting Protein

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e