pla2g4a
Share
  • Official Full Name
  • phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Background
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms
  • PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
Cat.#:PLA2G4A-12895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein, His-tagged
+Inquiry
Cat.#:PLA2G4A-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, His-tagged
+Inquiry
Cat.#:PLA2G4A-1752HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4A, GST-tagged
+Inquiry
Cat.#:PLA2G4A-30736THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLA2G4A
+Inquiry
Cat.#:PLA2G4A-42HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G4A protein, FLAG/His-tagged
+Inquiry
Cat.#:PLA2G4A-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G4A protein, MYC/DDK-tagged
+Inquiry
Cat.#:PLA2G4A-752HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human PLA2G4A Protein, His-tagged
+Inquiry
Cat.#:PLA2G4A-12894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G4A Protein
+Inquiry
Cat.#:PLA2G4A-6974CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G4A
+Inquiry
Cat.#:PLA2G4A-3141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4A 293 Cell Lysate
+Inquiry

Involved Pathway

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
STIL; GPD1C; PLA2G6; LYCAT; PTDSS1A; DGKE; LPCAT4; MBOAT2; DGKB; PCYT1BB
Ether lipid metabolism
CEPT1; PLA2G4C; LPCAT1; PAFAH2; PLA2G4AA; AGPS; UGT8; PAFAH1B2; LPCAT2; PLA2G4F
Arachidonic acid metabolism
CYP2P9; GPX1; PLB1; PLA2G1B; ALOX8; ALOX5AP; CYP1A2; PTGES3B; CBR2; ALOX15
Linoleic acid metabolism
PLA2G10; ALOX15; PLA2G3; CYP2C39; CYP2P8; CYP2P10; CYP2C45; CYP2C19; CYP2C50; CYP3A25
alpha-Linolenic acid metabolism
PLA2G2D; PLA2G5; PLA2G2F; FADS2; ACOX3; PLA2G4AA; PLA2G4C; PLA2G3; PLA2G6; PLA2G4A
Metabolic pathways
PNLIPRP1; SAT1; UOX; PGAM1B; CYP2P9; POLR3B; TWISTNB; KCNG4; GGT1; MGAT4A
MAPK signaling pathway
MAP3K7; RPS6KA3B; TNFRSF1A; NLK; GADD45B; GRB2A; PRKACBA; NF1; ARR3B; IL1R2
Ras signaling pathway
PLA2G10; CALM3; PIK3CB; PLA2G1B; KITLG; Fgf15; GNB3; IKBKB; FGF20; SOS1
Phospholipase D signaling pathway
AVPR1B; KRAS; PLD1; PDGFRA; AGPAT5; RHOA; Pdgfa&Pdgfb; FCER1G; AKT1; LPAR5
Vascular smooth muscle contraction
CALM3A; CALM1; PRKACG; ADORA2AA; ACTG2; PPP1CAB; PRKACAB; CYP4A14; ROCK1; ROCK2
VEGF signaling pathway
PTGS2B; NRAS; PIK3R1; MAPK12; KRAS; VEGFAA; AKT3A; PRKCA; BADB; PPP3CCA
Platelet activation
PLCG2; GNAI2; GNAI1; PIK3CD; PIK3CG; RHOA; NOS3; PIK3R3; VWF; SYK
Fc epsilon RI signaling pathway
TNF; PIK3R3; PLA2G4A; VAV3; MAPK13; MAP2K7; MAP2K2; PIK3R2; PIK3CG; INPP5D
Fc gamma R-mediated phagocytosis
AKT1; VAV3; PLA2G4F; LIMK1; SYK; PIK3CA; PIP5K1A; PPAP2B; PRKCA; VASP
Glutamatergic synapse
GNG5; SHANK3; PLD2; PRKACB; GRM6; PLCB3; DLGAP1; PRKACA; PPP3CA; PLCB4
Serotonergic synapse
GABRB1; GNB1; BRAF; GNAI1; ALOX12; SLC18A1; GNG10; CYP2D10; PRKCA; PRKACG
Long-term depression
PPP2R1B; GNAI2; GNAO1; GNA13; PLA2G4C; MAPK3; PLCB1; GNAI3; GRIA3; PPP2CB
Inflammatory mediator regulation of TRP channels
CYP4A12A; ALOX12E; IL1RAP; HTR2A; ASIC5; TRPM8; NTRK1; CAMK2A; TRPV3; HTR2C
GnRH signaling pathway
MMP2; RAF1B; PLD1; PTK2BB; ITPR3; Adcy4; MAP2K2B; PLA2G4A; CAMK2D2; ATF4B1
Ovarian steroidogenesis
BMP6; HSD17B7; HSD3B4; INSR; SCARB1; INS1; HSD17B1; GDF9; ALOX5; HSD3B1
Oxytocin signaling pathway
NPR1; CACNA2D2; CACNB4; CACNA2D3; PIK3CD; MYLK2; CAMK1D; CAMKK2; PLCB3; MAP2K1
Choline metabolism in cancer
PDGFB; PIK3CB; PPAP2A; WAS; AKT1; PRKCB; PIK3R3; RPS6KB1; SLC44A1; DGKD

Protein Function

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MEGF6; SPOCK3; CRTAC1; HPGDS; BGLAP-RS1; PCDHB16; THBS3A; PRRG3; CABP5A; ATP2A2
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G4A; PLA2G12A; PLA2G5; PLA2G4B; PLA2G3; PLA2G2A; PLA2G4F; PLA2G1B
Function calcium-dependent phospholipid binding
Related Protein CPNE3; CPNE1; SYT7; SYT11A; SYTL4; SYTL2; ANXA2; SYT11; DOC2D; SYTL1
Function lysophospholipase activity
Related Protein PNPLA8; LYPLAL1; PLA2G4AA; ASPG; Cel; PLB1; PNPLA7A; MGLL; ENPP2; PLA2G4F
Function phospholipase A2 activity
Related Protein OC90; PLA2G10; PLA2G2D; PLA2G2F; PLA2G2E; PNPLA3; PLA2G12B; PLA2G16; LCAT; PLA2G2A

Interacting Protein

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e