PLA2G4A

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PLA2G4A

Official Full Name phospholipase A2, group IVA (cytosolic, calcium-dependent)
Background This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Synonyms PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G4A-1752H Recombinant Human PLA2G4A, GST-tagged E.coli GST
    Human PLA2G4A-30736TH Recombinant Human PLA2G4A Wheat Germ N/A
    Human PLA2G4A-3141HCL Recombinant Human PLA2G4A 293 Cell Lysate HEK293 N/A
    Human PLA2G4A-42H Recombinant Human PLA2G4A protein, FLAG/His-tagged Insect Cell Flag/His
    Human PLA2G4A-526H Recombinant Human PLA2G4A protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLA2G4A-557H Recombinant Human PLA2G4A, His-tagged E.coli His
    Human PLA2G4A-752H Recombinant Human PLA2G4A Protein, His-tagged Sf21 Insect Cell His
    Mouse PLA2G4A-12894M Recombinant Mouse PLA2G4A Protein Mammalian Cell His
    Mouse PLA2G4A-12895M Recombinant Mouse PLA2G4A Protein, His-tagged E. coli His
    Chicken PLA2G4A-6974C Recombinant Chicken PLA2G4A Mammalian Cell His

    PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism LPCAT1; CDS1; DGKA; PLA2G2A; EPT1; PCYT1AB; PGS1; PLD3; CHAT; PLA2G3
    Ether lipid metabolism PLA2G6; PLD4; PAFAH1B1; PLA2G12B; GAL3ST1; PLD3; PLA2G4B; LPCAT1; EPT1; PLA2G3
    Arachidonic acid metabolism CYP2C8; CYP2P8; GPX6; PLA2G12A; CYP4A10; PTGDS; CYP4F2; CYP2C39; FAAH2A; PLA2G4D
    Linoleic acid metabolism CYP2P8; CYP2C45; CYP2C54; CYP2C9; PLA2G4F; PLA2G4AA; DHRS13L1; PLA2G2E; CYP3A25; PLA2G4D
    alpha-Linolenic acid metabolism PLA2G4F; ACAA1A; PLA2G12B; FADS2; PLA2G4AA; PLA2G1B; PLA2G6; PLA2G4A; PLA2G10; PLA2G2A
    Metabolic pathways PYGL; ALDH3A2; HYI; ACSL4A; MTAP; UGT2B15; A4GALT; LPIN1; UMPS; NMRK1
    MAPK signaling pathway Fasl; Casp3; RPS6KA2; C11orf52; MAPK7; FGF20; PPM1AB; MYCB; PRKACBB; MOS
    Ras signaling pathway PLA2G2A; RAP1A; RASA1; FGF11; ETS1; GNGT1; FGF4; NFKB1; PLA2G3; GNG2
    Phospholipase D signaling pathway AVPR2; MAP2K2; PDGFA; DGKD; TSC2; FCER1G; GAB1; RRAS2; INS1; KIT
    Vascular smooth muscle contraction CYP4A10; CALM; PLA2G10; CACNA1SA; PPP1CAB; PLA2G4C; GUCY1A3; PRKCG; CALML5; ARHGEF12
    VEGF signaling pathway VEGFAA; NFATC2; NRAS; SPHK1; SPHK2; PPP3R1B; PXNA; PIK3CG; PPP3CCB; CDC42L2
    Platelet activation FERMT3; ROCK1; PPP1R12A; APBB1IP; MYLK2; PLCB4; MAPK13; PIK3R1; FGG; GNAI1
    Fc epsilon RI signaling pathway PLCG2; LCP2; MAP2K6; PLA2G4A; PDPK1; PIK3CB; MAPK11; MAP2K1; PLA2G4F; MAPK9
    Fc gamma R-mediated phagocytosis PRKCB; PIK3CG; MAP2K1; PLCG1; PIK3R1; WAS; CFL2; FCGR1; ASAP2; PIP5K1C
    Glutamatergic synapse SLC1A3; PPP3CC; PLA2G4F; TRPC1; PPP3CB; GNG8; GRIN2D; SLC1A6; HOMER2; GNB4
    Serotonergic synapse HTR1E; ALOX12B; PLCB3; GNG7; NRAS; PLA2G4A; PRKCA; CYP2C54; GNG12; PLA2G4D
    Long-term depression PPP2CB; NRAS; PPP1R17; IGF1; KRAS; ITPR3; PRKCB; GRIA1; PLCB4; GRIA2
    Inflammatory mediator regulation of TRP channels MAP2K3; TRPV2; GNAQ; IL1B; CYP2C54; IGF1; PIK3CB; Adcy4; PRKCG; PIK3CD
    GnRH signaling pathway CAMK2G1; ITPR3; MAP2K3; GNAS; PLA2G4AA; Adcy4; CACNA1DA; PLCB2; PRKCA; MMP14B
    Ovarian steroidogenesis SCARB1; AKR1C3; BMP6; STAR; ACOT2; LHB; HSD17B2; ALOX5; FSHR; HSD17B7
    Oxytocin signaling pathway CAMK2D; NPR1; KCNJ14; NPR2; Adcy4; NFATC1; GUCY1A3; ACTG1; PPP3R2; RYR1
    Choline metabolism in cancer PDGFA; SOS1; PCYT1A; PIK3R3; CHKA; TAE1; PIK3CA; PDGFD; EIF4EBP1; WASF2

    PLA2G4A has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CASQ2; FAM20C; CDH3; CDHR1A; EFCAB7; NKD2A; PCDH2G2; ANXA5A; MYL2; EMR2
    calcium-dependent phospholipase A2 activity PLA2G3; PLA2G5; PLA2G4A; PLA2G2A; PLA2G12A; PLA2G4B; PLA2G4F; PLA2G1B
    calcium-dependent phospholipid binding ANXA3; ANXA11; ANXA7; ANXA2B; ANXA1C; SYTL4; ANXA1A; C2CD4B; SYT1; ANXA5A
    lysophospholipase activity PNPLA6; PNPLA7; PNPLA7A; PLB1; PLA2G4A; LYPLA1; MGLL; ENPP2; Cel; ASPG
    phospholipase A2 activity RARRES3; PNPLA3; PLA2G2F; PLA2G6; ABHD3; PLB1; PLA2G1B; PLA2G2D; LCAT; PLA2G4AA

    PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.

    ELF3; pi3p; Ccdc9; MYC; Eif3e

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