plcd4
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  • Official Full Name
  • phospholipase C, delta 4
  • Background
  • This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.
  • Synonyms
  • PLCD4; phospholipase C, delta 4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4; hPLCD4; MGC12837; Phosphoinositide phospholipase C delta 4; Phospholipase C delta 4; PLC delta 4; PLC delta4; phosphoinositide phospholipase C-delta-4
Cat.#:PLCD4-8268HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLCD4 protein, His & T7-tagged
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Cat.#:PLCD4-12922MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLCD4 Protein
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Cat.#:Plcd4-8269MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Plcd4 protein, His & T7-tagged
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Cat.#:PLCD4-4503RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PLCD4 Protein
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Cat.#:Plcd4-8270RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Plcd4 protein, His & T7-tagged
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Cat.#:PLCD4-3128HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLCD4 293 Cell Lysate
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Involved Pathway

PLCD4 involved in several pathways and played different roles in them. We selected most pathways PLCD4 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCD4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PTENA; PLCH1; PLCB4; PIK3CD; MTMR1A; PLCB3; INPP4A; INPP4B; PIP4K2C; PLCG2
Metabolic pathways
AKR1B7; COMTA; SGMS1; TDO2; CERS2; P4HA1B; ODC1; AGXT2L1; PKMB; IPMK
Calcium signaling pathway
GRIN2C; CAMK2B1; P2RX5; GNA11; ORAI1; ATP2A3; ADCY1A; DRD1A; PLCB1; CD38
Phosphatidylinositol signaling system
PLCD1A; PRKCBA; CALML3; IP6K3; PI4K2B; CDS1; TMEM55A; PIK3CA; INPP5D; CALML5
Thyroid hormone signaling pathway
KAT2A; ATP2A2; RCAN1; PLCD1; PLCB1; HDAC1; PRKACB; ATP1A3; PIK3R1; MED30

Protein Function

PLCD4 has several biochemical functions, for example, calcium ion binding, phosphatidylinositol phospholipase C activity, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCD4 itself. We selected most functions PLCD4 had, and list some proteins which have the same functions with PLCD4. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein ELTD1; PPEF2; TC2N; SPARC; GRM7; SCUBE3; PCDHGA2; RASGRP2; PCDHGA11; SLC25A25A
Function phosphatidylinositol phospholipase C activity
Related Protein PLCZ1; PLCL1; CHRM5; PLCL2; CHRM3; PLCE1; BDKRB2; PLCB2; PLCD4; EDNRA
Function signal transducer activity
Related Protein PPP5C; ADRA1BB; IL1RAP; GNG4; VMN1R43; CELSR3; ADRA2DA; NPY8AR; OLFCS2; AIP

Interacting Protein

PLCD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCD4.
TRIM39; IPO11

PLCD4 Related Articles

Mlcochova, P; Pelchen-Matthews, A; et al. Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages. BMC BIOLOGY 11:-(2013).
Yamaguchi, H; Yoshida, S; et al. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase I alpha are required for invadopodia formation in human breast cancer cells. CANCER SCIENCE 101:1632-1638(2010).