PLD2
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Official Full Name
phospholipase D2
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Overview
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PLD2; phospholipase D2; choline phosphatase 2; EC 3.1.4.4; hPLD 2; hPLD2; mPLD2; Phosphatidylcholine hydrolyzing phospholipase D2; Phosphatidylcholine-hydrolyzing phospholipase D2; PhospholipaseD2; PLD 2; PLD1C; Pldc; rPLD2; OTTHUMP00000115984;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | PLD2-683H | Recombinant Human Phospholipase D2 | E.coli | N/A | ||
Human | PLD2-679H | Recombinant Human PLD2, GST-tagged | Wheat Germ | GST | ||
Human | PLD2-301262H | Recombinant Human PLD2 protein, GST-tagged | E.coli | GST | Met1-Asn141 | |
Human | PLD2-383HF | Recombinant Full Length Human PLD2 Protein, GST-tagged | In Vitro Cell Free System | GST | 933 amino acids | |
Human | PLD2-3039H | Recombinant Human PLD2 protein, His-tagged | E.coli | His | 1-141 aa | |
Mouse | PLD2-12934M | Recombinant Mouse PLD2 Protein | Mammalian Cell | His | ||
Mouse | PLD2-6823M | Recombinant Mouse PLD2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | PLD2-6823M-B | Recombinant Mouse PLD2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | PLD2-4510R | Recombinant Rat PLD2 Protein | Mammalian Cell | His | ||
Rat | PLD2-4170R-B | Recombinant Rat PLD2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | PLD2-4170R | Recombinant Rat PLD2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- PLD2 Related Articles
- PLD2 Related Research Area
PLD2 involved in several pathways and played different roles in them. We selected most pathways PLD2 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerophospholipid metabolism | PNPLA7;GNPAT;DGKG;ACHE;PLA2G4C;LYPLA2;PHYKPL;CHAT;AGPAT9 |
Ether lipid metabolism | PAFAH1B1B;PPAP2C;PLA2G2F;PLD1;PLA2G4C;PAFAH2;PLA2G4AA;GAL3ST1;UGT8 |
Metabolic pathways | TYRP1B;GUK1B;GK2;ADO;ALG11;B3GNT2;CYP3A7-CYP3AP1;NDUFA10;GMPPAB |
Ras signaling pathway | PDGFB;IGF1R;GRIN2B;KITLG;RGL1;FGF8;PDGFRB;KRAS;MAPK10 |
cAMP signaling pathway | MAPK9;HHIP;GRIN1;GRIA2;CAMK2A;PIK3R5;PIK3CG;AKT2;ATP1A2 |
Sphingolipid signaling pathway | S1PR2;SPTLC2;SGPP2;GNAI1;RAC1;MAPK8;PIK3CD;TRP53;SMPD2 |
Phospholipase D signaling pathway | PLD2;SHC2;GRM6;PIP5K1B;FYN;LPAR2;PLA2G4D;MTOR;PDGFRA |
Endocytosis | AP2M1A;KDR;SRC;ARFGAP3;LDLRAP1A;HLA-C;AGAP1;KIT;SNX32 |
Fc gamma R-mediated phagocytosis | PLA2G4A;PIP5K1A;PIK3R5;PLCG2;FCGR2B;VASP;AMPH;PRKCG;PIK3R2 |
Glutamatergic synapse | PLCB4;TRPC1;GNG13;GRIA3;GRIK3;ITPR3;PRKCB;SLC17A8;ITPR1 |
GnRH signaling pathway | LHB;RAF1A;CALM2B;GNRHR1;MAPK14B;CALM3;CACNA1SA;MAPK1;MAP2K6 |
Choline metabolism in cancer | MAPK9;HRAS;PRKCA;PIP5K1A;PDGFRA;CHKA;SOS1;WASF1;PIK3CD |
PLD2 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidylinositol binding, phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD2 itself. We selected most functions PLD2 had, and list some proteins which have the same functions with PLD2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
N-acylphosphatidylethanolamine-specific phospholipase D activity | NAPEPLD;PLD1;PLD4;PLD2;PLD3 |
phosphatidylinositol binding | SNX12;SNX4;SNX2;SNX33;SNX10A;SNX5;SNX19A;FES;SNX27B |
phospholipase D activity | PLD3;PLD2;PLD1A;PLD1;PLD4;HMOX1;GPLD1 |
protein binding | TXK;MAP3K13;USP10;RAB5B;GLDN;PEX12;C21orf119;MAGEA2;CDYL2 |
PLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD2.
grb2_cerae_protein; GRB2; sos_chlae_protein; CFL1; ptpn1_cerae_protein; FTSJ1; CFTR
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