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PLD2

  • Official Full Name

    phospholipase D2

  • Overview

    The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PLD2; phospholipase D2; choline phosphatase 2; EC 3.1.4.4; hPLD 2; hPLD2; mPLD2; Phosphatidylcholine hydrolyzing phospholipase D2; Phosphatidylcholine-hydrolyzing phospholipase D2; PhospholipaseD2; PLD 2; PLD1C; Pldc; rPLD2; OTTHUMP00000115984;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLD2-683H Recombinant Human Phospholipase D2 E.coli N/A
Human PLD2-679H Recombinant Human PLD2, GST-tagged Wheat Germ GST
Human PLD2-301262H Recombinant Human PLD2 protein, GST-tagged E.coli GST Met1-Asn141
Human PLD2-383HF Recombinant Full Length Human PLD2 Protein, GST-tagged In Vitro Cell Free System GST 933 amino acids
Human PLD2-3039H Recombinant Human PLD2 protein, His-tagged E.coli His 1-141 aa
Mouse PLD2-12934M Recombinant Mouse PLD2 Protein Mammalian Cell His
Mouse PLD2-6823M Recombinant Mouse PLD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PLD2-6823M-B Recombinant Mouse PLD2 Protein Pre-coupled Magnetic Beads HEK293
Rat PLD2-4510R Recombinant Rat PLD2 Protein Mammalian Cell His
Rat PLD2-4170R-B Recombinant Rat PLD2 Protein Pre-coupled Magnetic Beads HEK293
Rat PLD2-4170R Recombinant Rat PLD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLD2 Related Articles
  • PLD2 Related Research Area

PLD2 involved in several pathways and played different roles in them. We selected most pathways PLD2 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismPNPLA7;GNPAT;DGKG;ACHE;PLA2G4C;LYPLA2;PHYKPL;CHAT;AGPAT9
Ether lipid metabolismPAFAH1B1B;PPAP2C;PLA2G2F;PLD1;PLA2G4C;PAFAH2;PLA2G4AA;GAL3ST1;UGT8
Metabolic pathwaysTYRP1B;GUK1B;GK2;ADO;ALG11;B3GNT2;CYP3A7-CYP3AP1;NDUFA10;GMPPAB
Ras signaling pathwayPDGFB;IGF1R;GRIN2B;KITLG;RGL1;FGF8;PDGFRB;KRAS;MAPK10
cAMP signaling pathwayMAPK9;HHIP;GRIN1;GRIA2;CAMK2A;PIK3R5;PIK3CG;AKT2;ATP1A2
Sphingolipid signaling pathwayS1PR2;SPTLC2;SGPP2;GNAI1;RAC1;MAPK8;PIK3CD;TRP53;SMPD2
Phospholipase D signaling pathwayPLD2;SHC2;GRM6;PIP5K1B;FYN;LPAR2;PLA2G4D;MTOR;PDGFRA
EndocytosisAP2M1A;KDR;SRC;ARFGAP3;LDLRAP1A;HLA-C;AGAP1;KIT;SNX32
Fc gamma R-mediated phagocytosisPLA2G4A;PIP5K1A;PIK3R5;PLCG2;FCGR2B;VASP;AMPH;PRKCG;PIK3R2
Glutamatergic synapsePLCB4;TRPC1;GNG13;GRIA3;GRIK3;ITPR3;PRKCB;SLC17A8;ITPR1
GnRH signaling pathwayLHB;RAF1A;CALM2B;GNRHR1;MAPK14B;CALM3;CACNA1SA;MAPK1;MAP2K6
Choline metabolism in cancerMAPK9;HRAS;PRKCA;PIP5K1A;PDGFRA;CHKA;SOS1;WASF1;PIK3CD

PLD2 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidylinositol binding, phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD2 itself. We selected most functions PLD2 had, and list some proteins which have the same functions with PLD2. You can find most of the proteins on our site.

Function Related Protein
N-acylphosphatidylethanolamine-specific phospholipase D activityNAPEPLD;PLD1;PLD4;PLD2;PLD3
phosphatidylinositol bindingSNX12;SNX4;SNX2;SNX33;SNX10A;SNX5;SNX19A;FES;SNX27B
phospholipase D activityPLD3;PLD2;PLD1A;PLD1;PLD4;HMOX1;GPLD1
protein bindingTXK;MAP3K13;USP10;RAB5B;GLDN;PEX12;C21orf119;MAGEA2;CDYL2

PLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD2.

grb2_cerae_protein; GRB2; sos_chlae_protein; CFL1; ptpn1_cerae_protein; FTSJ1; CFTR

Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).
Voss, KE; Bollag, RJ; et al. Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders. ARCHIVES OF DERMATOLOGICAL RESEARCH 303:591-600(2011).
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