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Official Full Name phospholipase D2
Background The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms PLD2; phospholipase D2; choline phosphatase 2; EC; hPLD 2; hPLD2; mPLD2; Phosphatidylcholine hydrolyzing phospholipase D2; Phosphatidylcholine-hydrolyzing phospholipase D2; PhospholipaseD2; PLD 2; PLD1C; Pldc; rPLD2; OTTHUMP00000115984
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLD2-679H Recombinant Human PLD2, GST-tagged Wheat Germ GST
    Human PLD2-683H Recombinant Human Phospholipase D2 E.coli N/A
    Mouse PLD2-12934M Recombinant Mouse PLD2 Protein Mammalian Cell His
    Rat PLD2-4510R Recombinant Rat PLD2 Protein Mammalian Cell His

    PLD2 involved in several pathways and played different roles in them. We selected most pathways PLD2 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism PLA2G16; PLA2G1B; DGKD; CDS1; LPGAT1; MBOAT1; PLB1; LPIN3; PCYT1AA; PHOSPHO1
    Ether lipid metabolism PAFAH2; PLA2G4A; PLA2G4D; CHPT1; PAFAH1B3; PLA2G12A; PLA2G2E; PLA2G12B; PLA2G2A; PLA2G4F
    Metabolic pathways ALDH2.2; DHRS3; ACSS2; ACSM2B; ALPI; ACOT2; PON3; CYP2U1; PTS; MCEE
    Ras signaling pathway FGFR3; INS1; MAPK8; FGFR2; PDGFRB; PIK3R5; RAC1; INS2; FGF4; Kitl
    cAMP signaling pathway FSHB; FFAR2; PPP1CA; SOX9; GRIN2A; TSHR; ORAI1; RRAS; CAMK2G; GLI3
    Sphingolipid signaling pathway LASS4; PLCB4; TP53; NRAS; S1PR5; PLCB2; SGMS1; PLD1; PPP2R5A; SGPL1
    Phospholipase D signaling pathway RAF1; RALGDS; INS1; PIK3CA; MAPK3; PIK3CB; PDGFRB; PPAP2B; PPAP2A; PIP5K1A
    Endocytosis AGAP2; KIF5A; SMAD3A; SMAD2; CXCR4; EPS15; LDLRAP1; EHD3; IST1; HLA-F
    Fc gamma R-mediated phagocytosis WASL; BIN1; PIP5K1B; GSN; DOCK2; RAC1; PLA2G4D; ARPC1A; RAF1; LAT
    Glutamatergic synapse SLC38A1; GRIK1; GNG13; GRIA4; PRKACB; SLC1A2; HOMER2; PRKCB; GRM5; PLCB1
    GnRH signaling pathway GNA11; HRASB; CALML3; MAP2K4A; CALM1; GNRHR1; PRKCA; CDC42; GNRHR4; GNAS
    Choline metabolism in cancer AKT2; PLD1; KRAS; WASF3; Pdgfa&Pdgfb; PPAP2B; EIF4EBP1; PIP5K1C; AKT1; SLC22A3

    PLD2 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidylinositol binding, phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD2 itself. We selected most functions PLD2 had, and list some proteins which have the same functions with PLD2. You can find most of the proteins on our site.

    Function Related Protein
    N-acylphosphatidylethanolamine-specific phospholipase D activity PLD1; PLD3; PLD4; NAPEPLD; PLD2
    phosphatidylinositol binding SNX13; PASK; AKR1C1; TULP4; CCDC88A; HIP1R; GRB7; TULP2; SNX6; MITD1
    phospholipase D activity PLD3; HMOX1; PLD2; PLD1; GPLD1; PLD1A; PLD4
    protein binding CREBBP; FAM32A; USP54; GATAD2B; CRYBA1; FAM72A; AKTIP; GAK; NAA35; CDC16

    PLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD2.

    grb2_cerae_protein; GRB2; sos_chlae_protein; CFL1; ptpn1_cerae_protein; FTSJ1; CFTR

    Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).
    Voss, KE; Bollag, RJ; et al. Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders. ARCHIVES OF DERMATOLOGICAL RESEARCH 303:591-600(2011).

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