pnlip
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  • Official Full Name
  • pancreatic lipase
  • Background
  • Pancreatic lipase, also known as pancreatic triacylglycerol lipase, is secreted from the pancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Triacylglycerol + H2O diacylglycerol + a fatty acid anion Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This protein belongs to pancreatic lipase family.
  • Synonyms
  • PNLIP; pancreatic lipase; PL; PTL; pancreatic triacylglycerol lipase; OTTHUMP00000020564; triacylglycerol acylhydrolase; Lipase
Cat.#:PNLIP-2415HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PNLIP Protein, MYC/DDK-tagged
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Cat.#:Pnlip-1331MTag:His|SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pnlip Protein, His-SUMO-tagged
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Cat.#:PNLIP-30776THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PNLIP
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Cat.#:PNLIP-8599HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PNLIP, His tagged
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Cat.#:Pnlip-6977MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pnlip protein, His & T7-tagged
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Cat.#:Pnlip-26RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pnlip protein, His-tagged
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Cat.#:PNLIP-4545RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PNLIP Protein
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Cat.#:PNLIP-4795CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PNLIP
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Cat.#:PNLIP-8203HTag:N/A
Source (Host):Human pancreasSpecies:Human
Product nameNative Human Pancreatic Lipase
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Cat.#:PNLIP-8205HTag:N/A
Source (Host):Human pancreasSpecies:Human
Product nameNative Human Pancreas Lipase
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Cat.#:PNLIP-1175PTag:N/A
Source (Host):Porcine PancreasSpecies:Pig
Product nameNative Porcine Pancreatic Lipase
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Cat.#:PNLIP-1246HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PNLIP cell lysate
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Cat.#:PNLIP-12HTag:N/A
Source (Host):Species:Human
Product nameHuman pancreatic lipase from pancreatic juice Reference Standard
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Cat.#:PNLIP-13HTag:N/A
Source (Host):Species:Human
Product nameRecombinant human pancreatic lipase Reference Standard
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Involved Pathway

PNLIP involved in several pathways and played different roles in them. We selected most pathways PNLIP participated on our site, such as Glycerolipid metabolism, Metabolic pathways, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNLIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerolipid metabolism
ALDH9A1B; MOGAT1; PPAP2B; MBOAT1; DGAT1A; PPAP2A; MOGAT2; AKR1B7; PNLIPRP3; DGKB
Metabolic pathways
MTHFD1L; PNLIPRP2; ADH7; ANPEPB; ACSL1B; GLUD1; ALG5; GCNT2; PAH; ADPGK
Pancreatic secretion
ITPR1; CTRL; RAB11A; PNLIP; ATP1B1; ATP1B2; RAP1B; SLC26A3; PLA2G2D; CLCA4
Fat digestion and absorption
PLA2G2E; PLA2G12B; AGPAT1; PPAP2C; PLA2G2A; PLA2G3; PLA2G2F; DGAT1; PLA2G1B; SCARB1
Vitamin digestion and absorption
MMACHC; APOA4; APOA1; SLC19A3; TCN2; SLC19A2; FOLH1; SLC46A1; BTD; GIF

Protein Function

PNLIP has several biochemical functions, for example, metal ion binding, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNLIP itself. We selected most functions PNLIP had, and list some proteins which have the same functions with PNLIP. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein ASNA1; ATP12A; POLI; C6AST4; CRYAA; ZBTB7B; ECE2; COL9A1; COL1A1; FDX1L
Function triglyceride lipase activity
Related Protein LIPCA; CES5A; CEL.1; PNPLA2; LIPF; PNLIPRP3; PNPLA4; LIPE; CES1D; AADAC

Interacting Protein

PNLIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNLIP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNLIP.
CLPS; YWHAE

PNLIP Related Articles

Hachero-Cruzado, I; Rodriguez-Rua, A; et al. Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 12:61-73(2014).
Behar, DM; Basel-Vanagaite, L; et al. Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency. JOURNAL OF LIPID RESEARCH 55:307-312(2014).