pnpla2
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  • Official Full Name
  • patatin-like phospholipase domain containing 2
  • Background
  • Adipose Triglyceride Lipase (ATGL), an enzyme that catalyzes the rate limiting hydrolysis step of triglycerides in the triacylglycerol lipolysis cascade, is expressed predominantly in adipose tissue, but is also found in lesser amounts within cardiac and skeletal muscle. Its function is to initiate the breakdown of intracellular triglycerides into fatty acid monomers. Individuals deficient in the ATGL enzyme are at higher risk for cardiac dysfunction and premature death because of increased size and accumulation of lipid droplets within cardiac myocytes.
  • Synonyms
  • PNPLA2; patatin-like phospholipase domain containing 2
Cat.#:PNPLA2-1333HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PNPLA2 Protein, His-SUMO-tagged
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Cat.#:PNPLA2-320HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PNPLA2 protein, MYC/DDK-tagged
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Cat.#:PNPLA2-322HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PNPLA2, His-tagged
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Cat.#:PNPLA2-13042MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PNPLA2 Protein
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Cat.#:PNPLA2-4552RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PNPLA2 Protein
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Cat.#:PNPLA2-3801CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PNPLA2
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Cat.#:PNPLA2-325HTag:GST
Source (Host):Species:Human
Product nameRecombinant Human PNPLA2, GST-tagged
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Cat.#:PNPLA2-3069HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PNPLA2 293 Cell Lysate
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Involved Pathway

PNPLA2 involved in several pathways and played different roles in them. We selected most pathways PNPLA2 participated on our site, such as Glycerolipid metabolism, Metabolic pathways, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerolipid metabolism
AKR1B1L; PPAP2B; ALDH2.1; DGKA; PPAP2C; AGPAT9L; AKR1B1; DGKAA; GLA; ALDH9A1A.1
Metabolic pathways
GCLM; CBR2; HMBSA; ENO1B; CPOX; HSD17B12B; DGAT1A; ADPGK; ACACB; NMNAT2
Regulation of lipolysis in adipocytes
NPY1R; GNAI1; IRS1; LOC100328615; Adcy4; PRKACG; PIK3CD; INS; PRKG1; LIPE

Protein Function

PNPLA2 has several biochemical functions, for example, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA2 itself. We selected most functions PNPLA2 had, and list some proteins which have the same functions with PNPLA2. You can find most of the proteins on our site.
Function
Related Protein
Function triglyceride lipase activity
Related Protein LPL; CES1D; CES1; Cel; PNPLA2; AADAC; CES5A; CEL.1; PNLIPRP3; PNLIPRP1

Interacting Protein

PNPLA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA2.
SMAD9; EGFR; MARK3; UBE2R2; ppk; PHYHIP; FKBP5