PNPLA2 Protein, patatin-like phospholipase domain containing 2

PNPLA2

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PNPLA2

Official Full Name patatin-like phospholipase domain containing 2
Background Adipose Triglyceride Lipase (ATGL), an enzyme that catalyzes the rate limiting hydrolysis step of triglycerides in the triacylglycerol lipolysis cascade, is expressed predominantly in adipose tissue, but is also found in lesser amounts within cardiac and skeletal muscle. Its function is to initiate the breakdown of intracellular triglycerides into fatty acid monomers. Individuals deficient in the ATGL enzyme are at higher risk for cardiac dysfunction and premature death because of increased size and accumulation of lipid droplets within cardiac myocytes.
Synonyms PNPLA2; patatin-like phospholipase domain containing 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PNPLA2-1333H Recombinant Human PNPLA2 Protein, His-SUMO-tagged E.coli His/SUMO
    Human PNPLA2-3069HCL Recombinant Human PNPLA2 293 Cell Lysate HEK293 N/A
    Human PNPLA2-320H Recombinant Human PNPLA2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PNPLA2-322H Recombinant Human PNPLA2, His-tagged E.coli His
    Human PNPLA2-325H Recombinant Human PNPLA2, GST-tagged Wheat Germ GST
    Mouse PNPLA2-13042M Recombinant Mouse PNPLA2 Protein Mammalian Cell His
    Rat PNPLA2-4552R Recombinant Rat PNPLA2 Protein Mammalian Cell His
    Chicken PNPLA2-3801C Recombinant Chicken PNPLA2 Mammalian Cell His

    PNPLA2 involved in several pathways and played different roles in them. We selected most pathways PNPLA2 participated on our site, such as Glycerolipid metabolism, Metabolic pathways, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerolipid metabolism PPAP2C; DGAT1; ALDH2; DGKAA; ALDH9A1A.1; ALDH1B1; DGKQ; TAE1; GLA; LIPC
    Metabolic pathways CYCSB; UPRT; PET112L; NME2B.1; PRPS1B; ADI1; GMPPA; AKR1B10; GALNTL1; PPT2
    Regulation of lipolysis in adipocytes LOC100328615; PIK3R1; IRS4; PRKACA; PIK3R2; PIK3CB; PIK3CG; INS1; PIK3R5; PRKACB

    PNPLA2 has several biochemical functions, for example, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA2 itself. We selected most functions PNPLA2 had, and list some proteins which have the same functions with PNPLA2. You can find most of the proteins on our site.

    Function Related Protein
    triglyceride lipase activity LIPF; CEL.1; PNLIPRP2; LIPE; CES3; LIPC; PNPLA2; PNPLA3; LIPCA; AADAC

    PNPLA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA2.

    SMAD9; EGFR; MARK3; UBE2R2; ppk; PHYHIP; FKBP5

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