PNPLA2
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Official Full Name
patatin-like phospholipase domain containing 2
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Overview
Adipose Triglyceride Lipase (ATGL), an enzyme that catalyzes the rate limiting hydrolysis step of triglycerides in the triacylglycerol lipolysis cascade, is expressed predominantly in adipose tissue, but is also found in lesser amounts within cardiac and skeletal muscle. Its function is to initiate the breakdown of intracellular triglycerides into fatty acid monomers. Individuals deficient in the ATGL enzyme are at higher risk for cardiac dysfunction and premature death because of increased size and accumulation of lipid droplets within cardiac myocytes. -
Synonyms
PNPLA2; patatin-like phospholipase domain containing 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PNPLA2 Related Research Area
PNPLA2 involved in several pathways and played different roles in them. We selected most pathways PNPLA2 participated on our site, such as Glycerolipid metabolism, Metabolic pathways, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Glycerolipid metabolism | glpK;LPIN3;GLA;AKR1B10;AKR1A1;MOGAT1;DGKA;GK2;DGKE |
Metabolic pathways | B3GNT1;AK7B;MTR;UPP1;PMM2;PNPLA2;COASY;NDUFS8;PNPLA3 |
Regulation of lipolysis in adipocytes | FABP4;PTGS2;PIK3R5;NPY;PRKACB;NPY1R;AQP7;GNAS;AKT2 |
PNPLA2 has several biochemical functions, for example, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA2 itself. We selected most functions PNPLA2 had, and list some proteins which have the same functions with PNPLA2. You can find most of the proteins on our site.
Function | Related Protein |
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triglyceride lipase activity | CES3;LPL;LIPF;PNLIP;LIPE;CES5A;CES1;PNPLA3;PNLIPRP3 |
PNPLA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA2.
SMAD9; EGFR; MARK3; UBE2R2; ppk; PHYHIP; FKBP5
- Q&As
- Reviews
Q&As (7)
Ask a questionPNPLA2 influences energy homeostasis in muscles, facilitating fatty acid oxidation for energy production.
Changes in PNPLA2 activity affect cardiovascular health, potentially influencing the development of atherosclerosis.
PNPLA2 regulates liver lipid metabolism, impacting the development of fatty liver disease.
Mutations in PNPLA2 can lead to lipid storage diseases by disrupting normal lipid metabolism.
PNPLA2 plays a significant role in obesity and metabolic syndrome, affecting lipid storage and energy balance.
PNPLA2 modulates inflammation and insulin sensitivity, influencing metabolic health and the risk of diabetes.
PNPLA2 is crucial for lipid metabolism, breaking down triglycerides in adipose tissue for energy use.
Customer Reviews (3)
Write a reviewQuick and precise protein expression, a valuable asset.
Exceptional protein purification, highly recommended for our research.
Dependable mass spectrometry analysis, enhances our proteomics research.
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