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PNPLA2

  • Official Full Name

    patatin-like phospholipase domain containing 2

  • Overview

    Adipose Triglyceride Lipase (ATGL), an enzyme that catalyzes the rate limiting hydrolysis step of triglycerides in the triacylglycerol lipolysis cascade, is expressed predominantly in adipose tissue, but is also found in lesser amounts within cardiac and skeletal muscle. Its function is to initiate the breakdown of intracellular triglycerides into fatty acid monomers. Individuals deficient in the ATGL enzyme are at higher risk for cardiac dysfunction and premature death because of increased size and accumulation of lipid droplets within cardiac myocytes.
  • Synonyms

    PNPLA2; patatin-like phospholipase domain containing 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PNPLA2-320H Recombinant Human PNPLA2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PNPLA2-325H Recombinant Human PNPLA2, GST-tagged Wheat Germ GST
Human PNPLA2-1333H Recombinant Human PNPLA2 Protein, His-SUMO-tagged E.coli His/SUMO
Human PNPLA2-322H Recombinant Human PNPLA2, His-tagged E.coli His
Human PNPLA2-3069HCL Recombinant Human PNPLA2 293 Cell Lysate HEK293 N/A
Human PNPLA2-381HF Recombinant Full Length Human PNPLA2 Protein In Vitro Cell Free System GST 504 amino acids
Human PNPLA2-251HFL Recombinant Full Length Human PNPLA2 Protein, C-Flag-tagged Mammalian cells Flag
Human PNPLA2-1724H-B Recombinant Human PNPLA2 Protein Pre-coupled Magnetic Beads HEK293
Human PNPLA2-1724H Recombinant Human PNPLA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PNPLA2-13042M Recombinant Mouse PNPLA2 Protein Mammalian Cell His
Mouse PNPLA2-6888M Recombinant Mouse PNPLA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PNPLA2-6888M-B Recombinant Mouse PNPLA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pnpla2-4972M Recombinant Mouse Pnpla2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PNPLA2-4552R Recombinant Rat PNPLA2 Protein Mammalian Cell His
Rat PNPLA2-4212R-B Recombinant Rat PNPLA2 Protein Pre-coupled Magnetic Beads HEK293
Rat PNPLA2-4212R Recombinant Rat PNPLA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rattus norvegicus (Rat) RFL26315RF Recombinant Full Length Rat Patatin-Like Phospholipase Domain-Containing Protein 2(Pnpla2) Protein, His-Tagged E.coli expression system His Full Length (1-478)
Chicken PNPLA2-3801C Recombinant Chicken PNPLA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PNPLA2 Related Research Area

PNPLA2 involved in several pathways and played different roles in them. We selected most pathways PNPLA2 participated on our site, such as Glycerolipid metabolism, Metabolic pathways, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerolipid metabolismglpK;LPIN3;GLA;AKR1B10;AKR1A1;MOGAT1;DGKA;GK2;DGKE
Metabolic pathwaysB3GNT1;AK7B;MTR;UPP1;PMM2;PNPLA2;COASY;NDUFS8;PNPLA3
Regulation of lipolysis in adipocytesFABP4;PTGS2;PIK3R5;NPY;PRKACB;NPY1R;AQP7;GNAS;AKT2

PNPLA2 has several biochemical functions, for example, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA2 itself. We selected most functions PNPLA2 had, and list some proteins which have the same functions with PNPLA2. You can find most of the proteins on our site.

Function Related Protein
triglyceride lipase activityCES3;LPL;LIPF;PNLIP;LIPE;CES5A;CES1;PNPLA3;PNLIPRP3

PNPLA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA2.

SMAD9; EGFR; MARK3; UBE2R2; ppk; PHYHIP; FKBP5

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does PNPLA2 influence energy homeostasis and fatty acid oxidation in muscle tissues? 05/12/2022

PNPLA2 influences energy homeostasis in muscles, facilitating fatty acid oxidation for energy production.

How do alterations in PNPLA2 expression or activity affect cardiovascular health and the risk of atherosclerosis? 04/07/2022

Changes in PNPLA2 activity affect cardiovascular health, potentially influencing the development of atherosclerosis.

How does PNPLA2 contribute to the regulation of hepatic lipid metabolism and the development of fatty liver disease? 02/11/2022

PNPLA2 regulates liver lipid metabolism, impacting the development of fatty liver disease.

What is the impact of PNPLA2 mutations on the pathogenesis of lipid storage diseases? 08/31/2021

Mutations in PNPLA2 can lead to lipid storage diseases by disrupting normal lipid metabolism.

What role does PNPLA2 play in the development and progression of obesity and related metabolic disorders? 08/19/2021

PNPLA2 plays a significant role in obesity and metabolic syndrome, affecting lipid storage and energy balance.

What are the mechanisms by which PNPLA2 modulates inflammation and insulin sensitivity? 06/08/2018

PNPLA2 modulates inflammation and insulin sensitivity, influencing metabolic health and the risk of diabetes.

How does PNPLA2 regulate lipid metabolism and triglyceride hydrolysis in adipose tissue? 01/29/2018

PNPLA2 is crucial for lipid metabolism, breaking down triglycerides in adipose tissue for energy use.

Customer Reviews (3)

Write a review
Reviews
05/14/2020

    Quick and precise protein expression, a valuable asset.

    09/09/2019

      Exceptional protein purification, highly recommended for our research.

      03/01/2018

        Dependable mass spectrometry analysis, enhances our proteomics research.

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