PNPLA8 Protein, patatin-like phospholipase domain containing 8

PNPLA8

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PNPLA8

Official Full Name patatin-like phospholipase domain containing 8
Background This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family;are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is;a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript;variants encoding different isoforms have been found for this gene.
Synonyms PNPLA8; patatin-like phospholipase domain containing 8; calcium-independent phospholipase A2-gamma; IPLA2(GAMMA); IPLA2 2; IPLA2G; PNPLA-gamma; iPLA2 gamma; iPLA2-gamma; patatin-like phospholipase domain-containing protein 8; membrane-associated calcium-i
    • Species :
    • Chicken
    • Mouse
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse PNPLA8-13047M Recombinant Mouse PNPLA8 Protein Mammalian Cell His
    Rhesus Macaque PNPLA8-3496R Recombinant Rhesus monkey PNPLA8 Protein, His-tagged Mammalian Cell His
    Chicken PNPLA8-3855C Recombinant Chicken PNPLA8 Mammalian Cell His

    PNPLA8 involved in several pathways and played different roles in them. We selected most pathways PNPLA8 participated on our site, such as Acyl chain remodelling of PC, Acyl chain remodelling of PE, Eicosanoid Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acyl chain remodelling of PC PLB1; PLA2G16; PNPLA8; PLA2G4B; PLBD1
    Acyl chain remodelling of PE PLA2G4B; PLBD1; PNPLA8; PLA2G16
    Eicosanoid Synthesis PNPLA8; DPEP1; ALOX5AP
    Glycerophospholipid biosynthesis CEPT1A; PLBD1; CHKA; BCHE; AGPAT6; CPNE6; PLA2G16; PEMT; PHOSPHO1; MGLL
    Metabolism TIAM2; GLIPR1; LRPPRC; LYPLA1; NFYBB; ARSF; NUDT3; ARSI; NUDT4; SLC25A21
    Metabolism of lipids and lipoproteins VAPB; GLTPD1; GGTLC1; COL4A3BP; FABP12; MED22; ARSD; PIK3R6; FABP11B; AKR1C2
    Phospholipid metabolism ABHD3; CPNE1; ABHD4; CDS1; ARF3; CEPT1; CPNE7; PLBD1; PNPLA8; PHOSPHO1

    PNPLA8 has several biochemical functions, for example, calcium-independent phospholipase A2 activity, hydrolase activity, lysophospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA8 itself. We selected most functions PNPLA8 had, and list some proteins which have the same functions with PNPLA8. You can find most of the proteins on our site.

    Function Related Protein
    calcium-independent phospholipase A2 activity PLA2G4C; PLA2G15; PLA2G7; PNPLA8
    hydrolase activity CTSL.1; SNRNP200; ATAD1A; AGBL1; AGBL4; GALCA; ASAH1A; ABHD2B; PTPN4B; PTPN23A
    lysophospholipase activity LYPLA1; PNPLA7; Cel; PLA2G4AA; PNPLA8; PLA2G4A; LGALS13; PNPLA6; PNPLA7A; MGLL

    PNPLA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA8.

    Huang, CF; Dai, CY; et al. Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY 62:512-518(2015).
    Mandorfer, M; Payer, BA; et al. Revisiting liver disease progression in HIV/HCV-coinfected patients: the influence of vitamin D, insulin resistance, immune status, IL28B and PNPLA3. LIVER INTERNATIONAL 35:876-885(2015).

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