pnpo
Share
  • Official Full Name
  • pyridoxamine 5-phosphate oxidase
  • Background
  • The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
  • Synonyms
  • PNPO; pyridoxamine 5-phosphate oxidase; pyridoxine 5 phosphate oxidase; pyridoxine-5-phosphate oxidase; PDXPO; EC 1.4.3.5; FLJ10535; PNPO_HUMAN; Pyridoxal 5 phosphate synthase; pyridoxamine 5 phosphate oxidase; Pyridoxamine phosphate oxidase; Pyridoxamine-phosphate oxidase; pyridoxal 5-phosphate synthase; pyridoxine 5-phosphate oxidase
Cat.#:PNPO-1820HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PNPO, GST-tagged
+Inquiry
Cat.#:PNPO-27512THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PNPO, His-tagged
+Inquiry
Cat.#:PNPO-13048MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PNPO Protein
+Inquiry
Cat.#:Pnpo-8034MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pnpo protein, His & T7-tagged
+Inquiry
Cat.#:PNPO-4553RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PNPO Protein
+Inquiry
Cat.#:PNPO-3497RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PNPO Protein, His-tagged
+Inquiry
Cat.#:PNPO-8118ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PNPO
+Inquiry
Cat.#:PNPO-2868HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pyridoxamine 5 -phosphate Oxidase, His-tagged
+Inquiry
Cat.#:PNPO-3065HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PNPO 293 Cell Lysate
+Inquiry

Involved Pathway

PNPO involved in several pathways and played different roles in them. We selected most pathways PNPO participated on our site, such as Vitamin B metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vitamin B metabolism
PDXKB; PSAT1; AOX4; AOX1; PDXKA; PHOSPHO2; PDXP; AOX3L1; AOX2P; PDXK
Metabolic pathways
TGDS; MOCS2; ATP6V1C1A; ATP6V1E1; ADSSL1; COX8A; ACSM2; DHRS4L2; MTMR2; COX4I1

Protein Function

PNPO has several biochemical functions, for example, FMN binding, pyridoxamine-phosphate oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPO itself. We selected most functions PNPO had, and list some proteins which have the same functions with PNPO. You can find most of the proteins on our site.
Function
Related Protein
Function FMN binding
Related Protein CREG2; DHODH; CREG1; NOS1; PNPO; MTRR; NOS2B; POR; NOS2A; TYW1
Function pyridoxamine-phosphate oxidase activity
Related Protein PNPO

Interacting Protein

PNPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPO here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPO.
MYO1C; Junb

PNPO Related Gene Family

Cytokines