polr2e
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  • Official Full Name
  • polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
  • Background
  • This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
  • Synonyms
  • POLR2E; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; polymerase (RNA) II (DNA directed) polypeptide E (25kD); DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA directed RNA polymerase II 23 kda polypeptide; hRPB25; hsRPB5; RPABC1; RPB5; XAP4; and III subunit ABC1; and III subunit RPABC1; II; DNA directed RNA polymerase II polypeptide E; DNA directed RNA polymerase II subunit E; DNA directed RNA polymerases I II and III subunit RPABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerases I; RNA polymerases I; RNA polymerases I, II, and III subunit ABC1; RPAB1_HUMAN; RPB5 homolog
Cat.#:POLR2E-1843HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E, GST-tagged
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Cat.#:POLR2E-28615THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E, His-tagged
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Cat.#:POLR2E-521HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E
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Cat.#:POLR2E-7061HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2E, His-tagged
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Cat.#:POLR2E-4569RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat POLR2E Protein
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Cat.#:POLR2E-3034HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human POLR2E 293 Cell Lysate
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Involved Pathway

POLR2E involved in several pathways and played different roles in them. We selected most pathways POLR2E participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
URAH; NME2A; AK2; PDE3B; POLD1; AK4; PPAT; NPR1A; PDE8B; PDE8A
Pyrimidine metabolism
POLR1E; TXNRD1; UCK2; POLR2GL; NME6; UCKL1; POLA1; POLR2I; TXNRD3; NME3
Metabolic pathways
CYP4F18; B3GALT5; PTGES; MTHFR; CBR2; GRHPRA; PDXP; B3GNT4; HAO1; CYP4A12A
RNA polymerase
POLR3B; POLR2I; POLR2G; POLR3K; POLR2J; POLR3D; POLR2F; POLR1D; POLR1B; POLR2B
Cytosolic DNA-sensing pathway
MB21D1; IFNA7; POLR2K; Ifna11; IFNA21; CCL4L2; IFNB1; POLR3A; IFNA1; IFNA6
Huntingtons disease
REST; COX4I1; DNAHC8; COX6B2; ATP5O; PPIF; VDAC3; HDAC1; NDUFAB1; NDUFA8
Epstein-Barr virus infection
IFNG; CDK1; POLR2J; CD58; CD38; TRP53; POLR2D; YWHAG; HSPA6; POLR2G

Protein Function

POLR2E has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2E itself. We selected most functions POLR2E had, and list some proteins which have the same functions with POLR2E. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFAND5B; ZNF227; REV3L; DNMT1; HOXC12A; FOXS1; HOXA5A; HMGB1A; GTF2A1; PREB
Function DNA-directed RNA polymerase activity
Related Protein MED21; CD3EAP; PRIM2; POLR3C; POLR3F; POLR2GL; POLR2E; POLR2EB; MED20; POLR3K
Function contributes_to RNA polymerase I activity
Related Protein POLR2E; POLR1D; POLR2EB; TWISTNB; POLR1A; POLR1E; POLR2H; POLR2L; POLR2F; POLR1C
Function contributes_to RNA polymerase II activity
Related Protein POLR2J2; POLR2F; POLR2K; POLR2J; POLR2EB; POLR2A; POLR2C; POLR2H; POLR2B; POLR2J3
Function contributes_to RNA polymerase III activity
Related Protein POLR3C; POLR3E; POLR3F; POLR2K; POLR2F; POLR3D; POLR2EB; POLR3B; POLR3K; POLR3H
Function protein binding
Related Protein GAK; GNA13; NIPAL3; MYL6B; EIF6; CTCF; PHF21A; GGT1; DDX39A; TMEM218

Interacting Protein

POLR2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2E here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2E.
URI1; MED19; MED26; POLR1A; HSP90AA1; TTI1; SRPK1; CDH1; USP11; POLR1E