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POLR2E

  • Official Full Name

    polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

  • Overview

    This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
  • Synonyms

    POLR2E; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; polymerase (RNA) II (DNA directed) polypeptide E (25kD); DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA directed RNA polymerase II 23 kda polypeptide; hRPB25; hsRPB5; RPABC1; RPB5; XAP4; and III subunit ABC1; and III subunit RPABC1; II; DNA directed RNA polymerase II polypeptide E; DNA directed RNA polymerase II subunit E; DNA directed RNA polymerases I II and III subunit RPABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerases I; RNA polymerases I; RNA polymerases I, II, and III subunit ABC1; RPAB1_HUMAN; RPB5 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR2E-7061H Recombinant Human POLR2E, His-tagged E.coli His 1-210aa
Human POLR2E-28615TH Recombinant Human POLR2E, His-tagged E.coli His
Human POLR2E-521H Recombinant Human POLR2E E.coli N/A
Human POLR2E-1843H Recombinant Human POLR2E, GST-tagged E.coli GST 1-210aa
Human POLR2E-3034HCL Recombinant Human POLR2E 293 Cell Lysate HEK293 N/A
Human POLR2E-2514H Recombinant Human POLR2E Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Polr2e-4997M Recombinant Mouse Polr2e Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat POLR2E-4569R Recombinant Rat POLR2E Protein Mammalian Cell His
Rat POLR2E-4229R-B Recombinant Rat POLR2E Protein Pre-coupled Magnetic Beads HEK293
Rat POLR2E-4229R Recombinant Rat POLR2E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

POLR2E involved in several pathways and played different roles in them. We selected most pathways POLR2E participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPKM2;NME2A;ATIC;PNP5B;POLE2;Adcy4;ENTPD5;POLR2A;AK2
Pyrimidine metabolismDPYDA.1;POLR2L;TK2;CTPS1A;POLR3B;NME7;NT5C3B;POLR2J;DPYDB
Metabolic pathwaysSORD;CYP4A12A;AMPD2;HPSE2;OAT;ACLY;NDUFA7;DGKE;AUH
RNA polymerasePOLR2D;POLR3A;POLR3GL;POLR2EB;POLR2F;POLR2J;POLR2E;POLR3D;POLR3GLB
Cytosolic DNA-sensing pathwayPOLR2L;RELA;POLR3D;IFNA12;IFNA7;POLR3GLB;IFNA17;IFNA21;ADAR
Huntingtons diseaseCOX7B;HDAC2;SDHB;COX6A2;NDUFA13;SDHD;NDUFB10;COX7B2;DNALC4
Epstein-Barr virus infectionHLA-DRB3;EIF2AK4;HLA-B;ITGAL;RELB;PLCG1;POLR2J3;AKAP8L;TNFAIP3

POLR2E has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2E itself. We selected most functions POLR2E had, and list some proteins which have the same functions with POLR2E. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHMGXB3;GTF2A1;ZFP787;ZNF285A;GFI1B;ZBED2;SYCP3;ZFY1;CALR
DNA-directed RNA polymerase activityMED20;POLR3B;PRIM2;POLR2J;CD3EAP;POLR3A;POLR3F;POLR3G;RPAP1
contributes_to RNA polymerase I activityPOLR1E;POLR2H;POLR2E;TWISTNB;POLR2L;ZNRD1;POLR2K;POLR1D;POLR1A
contributes_to RNA polymerase II activityPOLR2F;POLR2B;POLR2J3;POLR2K;POLR2L;POLR2A;POLR2EB;POLR2E;POLR2C
contributes_to RNA polymerase III activityPOLR1D;POLR3D;POLR2F;POLR1C;POLR3G;POLR2K;POLR3GL;POLR3K;POLR2EB
protein bindingTMEM19;WWP2;HFE;CPSF4;USE1;AMHR2;PCDH18;FOXB1;HSF2

POLR2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2E here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2E.

URI1; MED19; MED26; POLR1A; HSP90AA1; TTI1; SRPK1; CDH1; USP11; POLR1E

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