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POMC

  • Official Full Name

    proopiomelanocortin

  • Overview

    Melanocyte-stimulating hormone belongs to a group called the melanocortins. This group includes ACTH, alpha-MSH, beta-MSH and gamma-MSH; these peptides are all cleavage products of a large precursor peptide called pro-opiomelanocortin (POMC). Alpha-MSH is the most important melanocortin for pigmentation. It increases the pigmentation of skin by increasing melanin production in melanocytes.
  • Synonyms

    POMC; proopiomelanocortin; LPH; MSH; NPP; POC; ACTH; CLIP; adrenocorticotropic hormone; adrenocorticotropin; alpha-melanocyte stimulating hormone; beta-endorphin; beta-lipotropin; beta-melanocyte stimulating hormone; Pro-opiomelanocortin; Corticotropin-lipotropin; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin; pro-opiomelanocortin; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; OTTHUMP00000119991; OTTHUMP00000200964; OTTHUMP00000200965; OTTHUMP00000200966; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; adrenocorticotropin; corticotropin-lipotropin; proopiomelanocortin preproprotein; corticotropin-like intermediary peptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human
  • Mammalian Cell
  • Synthetic
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POMC-339H Recombinant Human Proopiomelanocortin Synthetic N/A
Human POMC-30690TH Recombinant Human POMC, His-tagged E.coli His 241 amino acids
Human POMC-3548H Recombinant Human Pro-opiomelanocortin, His-tagged E.coli His
Human POMC-349H Recombinant Human Proopiomelanocortin, His-tagged Human His
Human POMC-1854H Recombinant Human POMC, His-tagged E.coli His 27-176aa
Human POMC-3018HCL Recombinant Human POMC 293 Cell Lysate HEK293 N/A
Human POMC-4952H Recombinant Human POMC Protein (Glu179-Glu267), N-His tagged E.coli N-His Glu179-Glu267
Mouse POMC-13117M Recombinant Mouse POMC Protein Mammalian Cell His
Mouse Pomc-6794M Recombinant Mouse Pomc protein, His-tagged E.coli His Trp27~Gln235 (Accession # P01193)
Mouse POMC-6936M-B Recombinant Mouse POMC Protein Pre-coupled Magnetic Beads HEK293
Mouse POMC-6936M Recombinant Mouse POMC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Pomc-6795R Recombinant Rat Pomc protein, His & GST-tagged E.coli His/GST Trp27~Gln235 (Accession # P01194)
Chicken POMC-2772C Recombinant Chicken POMC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POMC Related Articles

POMC involved in several pathways and played different roles in them. We selected most pathways POMC participated on our site, such as Melanogenesis, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with POMC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MelanogenesisWNT11B;FZD7;LEF1;WNT8A;DVL1B;FZD9B;CAMK2D1;a;FZD5
Adipocytokine signaling pathwayNFKBIA;CD36;ACSL1A;ACSBG2;ACSL3;POMCA;JAK2;G6PC2;LEPR

POMC has several biochemical functions, for example, G-protein coupled receptor binding, hormone activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POMC itself. We selected most functions POMC had, and list some proteins which have the same functions with POMC. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingUSP33;SFTPB;PICK1;S1PR1;RSPO4;HSPA1A;RSPO3;GNA15.1;STUB1
hormone activityPTH;POMCB;INS2;AGT;LHB;EDN3;BNP;STC2;PRL2C3
receptor bindingTAC4;PPP2R4;FGG;GRIN2A;NPFFL;PTK2AA;TENM2;CALCA;REN
type 1 melanocortin receptor bindingPOMC;AGRP2;MRAP2;MRAP
type 3 melanocortin receptor bindinga;ASIP;MRAP;MRAP2;POMC
type 4 melanocortin receptor bindinga;ASIP;MRAP2;POMC;MRAP

POMC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POMC here. Most of them are supplied by our site. Hope this information will be useful for your research of POMC.

Dieudonne, M; Ramesh, KV; et al. Modeling the interactions between MC2R and ACTH models from human. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 33:770-788(2015).
Bassi, M; Nakamura, NB; et al. Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. ACTA PHYSIOLOGICA 213:893-901(2015).
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