Recombinant Human Proopiomelanocortin, His-tagged
Cat.No. : | POMC-349H |
Product Overview : | Recombinant humanPOMC protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | POMC-349H |
Description : | Pro-opiomelanocortinpreproprotein, also known as POMC, a polypeptide hormone precursor thatundergoes extensive, tissue-specific, post-translational processing viacleavage by subtilisin-like enzymes known as prohormone convertases. Itregulates the corticosteroid production in the adrenal cortex. Also, POMC iscleaved into ten hormone chains named NPP, gamma-MSH, ACTH, alpha-MSH, CLIP,Lipotropin beta, Lipotropin gamma, Beta-MSH, Beta-endorphin andMet-enkephalin. Defects in the gene that encodes POMC are the cause of POMCdeficiency, which is characterized by red hair and adrenal insufficiency. |
Concentration : | 0.25 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 50% glyceroland 0.2M NaCl. |
Purity : | > 85% by SDS -PAGE |
Sequence : | 27-267 amino acids:MGSSHHHHHH SSGLVPRGSH MWCLESSQCQ DLTTESNLLE CIRACKPDLS AETPMFPGNG DEQPLTENPRKYVMGHFRWD RFGRRNSSSS GSSGAGQKRE DVSAGEDCGP LPEGGPEPRS DGAKPGPREG KRSYSMEHFRWGKPVGKKRR PVKVYPNGAE DESAEAFPLE FKRELTGQRL REGDGPDGPA DDGAGAQADL EHSLLVAAEKKDE |
Molecular Mass : | 28.9 kDa(262aa), confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appearhigher). |
Applications : | SDS-PAGE |
Storage : | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | POMC |
Gene Name : | POMC proopiomelanocortin [ Homosapiens ] |
Synonyms : | POMC;proopiomelanocortin; LPH; MSH; NPP; POC; ACTH; CLIP; pro-opiomelanocortin;beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin;met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta;melanotropin alpha; melanotropin gamma; OTTHUMP00000119991;pro-ACTH-endorphin; polypeptide; preproprotein; OTTHUMP00000200964; OTTHUMP00000200965;OTTHUMP00000200966; adrenocorticotropin corticotropin-lipotropin;adrenocorticotropic hormone; corticotropin-like intermediary peptide;beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone |
Gene ID : | 5443 |
mRNA Refseq : | NM_000939 |
Protein Refseq : | NP_000930 |
MIM : | 176830 |
UniProt ID : | P01189 |
Chromosome Location : | 2p23.3 |
Pathway : | Adipocytokinesignaling pathway; Class A/1 (Rhodopsin-like receptors); G alpha (i)signalling events; G alpha (s) signalling events; G-protein activation; GPCRdownstream signaling; GPCR ligand binding; Melanogenesis; Metabolism of aminoacids and derivatives; Opioid Signalling; Peptide hormone biosynthesis;Signaling by GPCR; Syndecan-3-mediated signaling events |
Function : | G-protein-coupledreceptor binding; hormone activity; receptor binding; type 1 melanocortinreceptor binding; type 2 melanocortin receptor binding; type 3 melanocortinreceptor binding; type 4 melanocortin receptor binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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