ppara
Share
  • Official Full Name
  • peroxisome proliferator-activated receptor alpha
  • Background
  • Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
  • Synonyms
  • PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1; MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferator activated receptor alpha; PPAR; PPAR-alpha; PPARA_HUMAN; PPARalpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha var
Cat.#:PPARA-1066HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA Protein, His-tagged
+Inquiry
Cat.#:PPARA-1083HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxisome Proliferator-activated Receptor Alpha
+Inquiry
Cat.#:PPARA-1084HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, GST-tagged
+Inquiry
Cat.#:PPARA-1085HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, LB Domain, 170-468aa
+Inquiry
Cat.#:PPARA-1086HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, LB Domain, GST-tagged
+Inquiry
Cat.#:PPARA-2740HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, His-tagged
+Inquiry
Cat.#:PPARA-113HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PPARA, GST-tagged
+Inquiry
Cat.#:PPARA-236HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human PPARA protein, His-tagged
+Inquiry
Cat.#:PPARA-28675THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA
+Inquiry
Cat.#:PPARA-29987THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, His-tagged
+Inquiry
Cat.#:PPARA-318HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA protein, His/MBP-tagged
+Inquiry
Cat.#:PPARA-319HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA protein, His/MBP-tagged
+Inquiry
Cat.#:Ppara-10MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppara protein, His-tagged
+Inquiry
Cat.#:PPARA-13160MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARA Protein
+Inquiry
Cat.#:PPARA-4592RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPARA Protein
+Inquiry
Cat.#:PPARA-3536RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPARA Protein, His-tagged
+Inquiry
Cat.#:PPARA-1107CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPARA
+Inquiry
Cat.#:PPARA-2987HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPARA 293 Cell Lysate
+Inquiry

Involved Pathway

PPARA involved in several pathways and played different roles in them. We selected most pathways PPARA participated on our site, such as PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
RXRAA; GK2; PPARAB; CYP4A12A; HMGCS2; ADIPOQ; ACOX1; PPARDB; CYP4A14; LPL
cAMP signaling pathway
SUCNR1; HCN4; ATP1A4; VAV3; GRIN3B; ATP1B2; PIK3CA; MAPK9; PIK3R3; CREB5
Adipocytokine signaling pathway
PTPN11B; ACSL1A; AGRP; STAT3; ADIPOQ; NPY; NFKBIAB; CPT1A; G6PCA.1; ACSBG2
Glucagon signaling pathway
PGAM1; CALM3; GNAS; GYS2; PDE3B; PRKACB; PLCB4; PPP3CC; ATF4; CPT1C
Insulin resistance
CREB5; PPP1R3B; PTPRF; RPS6KB2; PIK3CA; TNFRSF1A; PRKCB; MAPK9; GFPT2; PPP1CA
Non-alcoholic fatty liver disease (NAFLD)
TNFRSF1A; NDUFV3; NDUFB8; COX7B; RELA; SDHC; PPARA; ITCH; CDC42; PIK3CA
Hepatitis C
TRAF6; PIK3CB; IFNA21; BAD; TYK2; PPP2R2D; IFNA10; GRB2; PIK3R1; NRAS

Protein Function

PPARA has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NFAT protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARA itself. We selected most functions PPARA had, and list some proteins which have the same functions with PPARA. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DLX4A; TMEM18; CCDC79; NR2F1A; MYNN; ADNP2; PDCD2; LHX1B; RFX5; FOXO3A
Function MDM2/MDM4 family protein binding
Related Protein CAV1; PPARA; CDKN2A; TRP53; PSME3; CDK5RAP3; RFWD3
Function NFAT protein binding
Related Protein GATA4; SFPI1; PPARA; MAPK14; FOXP3; SPI1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FOXK2; HOXA10; NCOA2; ZNF92; SNAI3; STAT3; LEF1; NR6A1; MYOD1; BSX
Function RNA polymerase II repressing transcription factor binding
Related Protein TTC8; DMAP1; BBS5; RBPJ; STAT3; MTA2; HDAC2; MKKS; BBS4; RBBP8
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein RXRB; RORCB; NR2F6; PPARD; STAT3; NR0B1; PPARDB; AHR; NR1I3; NR2E3
Function drug binding
Related Protein PDE2A; UGT1A7; CHRNB4; PDE4D; FABP1; CYP2D6; P2RX4; ABP1; HTR1B; HMGB2
Function lipid binding
Related Protein HDLBP; PITPNA; ATP5G3; FABP9; APOA4; ACOT11; APOL6; FABP6; DOK7; EPN2
Function phosphatase binding
Related Protein PPP1R21; SMAD2; PPP1R36; DLG1L; DYSFIP1; PPARA; WNK1; DLG3; PPP1R37; PPP1R32
Function protein binding
Related Protein MRPL53; CLCN1; CUL4A; MARCH5; PSEN2; CD4; PARVA; TCTEX1D2; TUSC2; KCND3
Function protein complex binding
Related Protein SLC9A3R1; CCND1; PPIB; SH2B3; LCA5; CRHR1; CDK2; RPH3A; Apba1; HTR2A
Function protein domain specific binding
Related Protein NLRP1; NR0B2; EZR; VRK2; STAMBP; COX4I2; MRPL17; RQCD1; HIST1H4J; STXBP1
Function sequence-specific DNA binding
Related Protein SNAI2; SPI1B; RXRAB; HLX1; ZBTB49; ENG2A; RARGA; GATAD2AB; HSF5; LBX1
Function steroid hormone receptor activity
Related Protein RORAA; RORC; PPARG; RARB; NR5A5; THRA; NR0B2; PAQR7B; NR5A1B; NR1H4
Function transcription factor activity, sequence-specific DNA binding
Related Protein SIN3A; RUNX1T1; UHRF1; BATF3; ZNF286A; FOXO3A; LEF1; HOXC4A; PAX3; FOXK2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein ONECUT1; SOX2; CEBPB; MIXL1; EGR2; STAT3; ARID3B; SOX12; E2F4; NR4A2
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein KLF4; SOX10; MED12; KLF14; LMO2; CREB1; FOXH1; GBX2; PITX1; MIXL1
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein BATF3; NACC2; HELT; SNAI1; GZF1; SKIL; ZFP746; HES1; AEBP2; NFIL3-6
Function ubiquitin conjugating enzyme binding
Related Protein TOLLIP; RNF19B; RASD2; RNF14; DCUN1D4; PARK2; DCUN1D5; UBE2V1; RNF180; TCHP
Function zinc ion binding
Related Protein RNF166; MEP1B; PHF7; TRPS1; BARD1; NR2F1B; ZNRF4; TRIM62; DTX2; TRAF2

Interacting Protein

PPARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARA.
NCOR2; GRB2; CHD9; NCOR1; PIK3R3; UBE2I; PRMT2; MED1; LAMTOR5; RXRG; FOXA3; CDK3; PRMT1

PPARA Related Articles

Lu, Y; Liu, X; et al. Periostin promotes liver steatosis and hypertriglyceridernia through dovvnregulation of PPAR alpha. JOURNAL OF CLINICAL INVESTIGATION 124:3501-3513(2014).
Kienesberger, K; Pordes, AG; et al. L-carnitine and PPAR alpha-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cells. BMC GENOMICS 15:-(2014).