ppara
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  • Official Full Name
  • peroxisome proliferator-activated receptor alpha
  • Background
  • Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
  • Synonyms
  • PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1; MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferator activated receptor alpha; PPAR; PPAR-alpha; PPARA_HUMAN; PPARalpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha var
Cat.#:PPARA-1066HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA Protein, His-tagged
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Cat.#:PPARA-1083HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxisome Proliferator-activated Receptor Alpha
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Cat.#:PPARA-1084HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, GST-tagged
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Cat.#:PPARA-1085HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, LB Domain, 170-468aa
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Cat.#:PPARA-1086HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, LB Domain, GST-tagged
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Cat.#:PPARA-2740HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, His-tagged
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Cat.#:PPARA-113HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PPARA, GST-tagged
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Cat.#:PPARA-236HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human PPARA protein, His-tagged
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Cat.#:PPARA-28675THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA
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Cat.#:PPARA-29987THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, His-tagged
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Cat.#:PPARA-318HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA protein, His/MBP-tagged
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Cat.#:PPARA-319HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA protein, His/MBP-tagged
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Cat.#:Ppara-10MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppara protein, His-tagged
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Cat.#:PPARA-13160MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARA Protein
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Cat.#:PPARA-4592RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPARA Protein
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Cat.#:PPARA-3536RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPARA Protein, His-tagged
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Cat.#:PPARA-1107CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPARA
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Cat.#:PPARA-2987HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPARA 293 Cell Lysate
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Involved Pathway

PPARA involved in several pathways and played different roles in them. We selected most pathways PPARA participated on our site, such as PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
ACSL1; PCK2; ACOX1; SCP2A; SCP2; APOC3; SLC27A1A; CD36; OLR1; GK2
cAMP signaling pathway
MAPK10; PIK3CD; CALM3; FFAR2; HCN4; PTGER2; ATP1A1; NPR1; ATP1B2; PLD1
Adipocytokine signaling pathway
PRKAB2; IRS2; PPARAB; LEPB; PRKAB1; RXRB; NFKBIAA; ACSL4A; RXRAA; ACSL1B
Glucagon signaling pathway
CAMK2A; AKT2; PHKB; LDHAL6A; CPT1C; PPP3CA; PKM; CALM2; GCGR; PKM2
Insulin resistance
PPP1R3DA; SLC27A5; INS; SLC27A1B; PDPK1B; PIK3R2; NR1H3; CREB1A; PDPK1; INS1
Non-alcoholic fatty liver disease (NAFLD)
COX7A2L; CASP7; UQCRFS1; NDUFS2; NDUFB5; Casp3; PRKAG1; ADIPOR1; NFKB1; NDUFA5
Hepatitis C
GSK3B; IFNA1; IFNA2; OAS2; EIF2AK1; CLDN10; AKT2; PDPK1; PIK3R3; CLDN17

Protein Function

PPARA has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NFAT protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARA itself. We selected most functions PPARA had, and list some proteins which have the same functions with PPARA. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HER9; HEMK1; ELK4; LEF1; HOXC12A; ZNF576; ZNF614; FOXO1A; BARHL1A; CRY2
Function MDM2/MDM4 family protein binding
Related Protein CDKN2A; CDK5RAP3; TRP53; PPARA; CAV1; RFWD3; PSME3
Function NFAT protein binding
Related Protein PPARA; SFPI1; FOXP3; SPI1; GATA4; MAPK14
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TBP; NFE2L3; CLOCK; ZFP536; POU2F3; ALS2CR8; TCF3B; MEF2A; ZNF460; BATF2
Function RNA polymerase II repressing transcription factor binding
Related Protein MIXL1; RBPJ; TBP; BBS2; TTC8; SIN3A; PROL1; HDAC2; GTF2A2; BBS5
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein VDRA; PPARAA; NR4A1; AHR2; RORC; PPARAB; RORAA; NR1I3; NR2F1B; NR2F1
Function drug binding
Related Protein GLRB; Alb; SFRP1; PYGB; ACE; PDE2A; HTR2C; IL2RA; PPARG; DCK
Function lipid binding
Related Protein ACBD6; ALOX8; APODB; STARD6; COQ9; PFN3; PLTP; NME4; PITPNB; STARD8
Function phosphatase binding
Related Protein SMAD2; DYSFIP1; CARHSP1; CRY1; SH3RF2; DLG1L; KLRAQ1; DLG3; SLC9A3R2; PPP1R26
Function protein binding
Related Protein PRKCB; METTL15; TXNRD3; DLC1; RNASE1; PODXL; ALPL; SP140; ARL6IP1; SGSM3
Function protein complex binding
Related Protein Casp3; UGT1A6B; KAT2B; PPFIA2; TG; AP2A1; HADHA; WASF2; MLKL; Cel
Function protein domain specific binding
Related Protein SHROOM2; MYH9; STXBP1; FOXA1; ABCC2; TJP1; HIST2H4A; RAB27A; MLF1; NLRP1
Function sequence-specific DNA binding
Related Protein CLOCK; SPIB; FOXS1; RX3; TBX5A; SCAND2P; HOXA13; IRX5A; HOXC1A; HSF4
Function steroid hormone receptor activity
Related Protein NR6A1B; THRB; RARAB; NR0B1; THRA; NR1D2B; NR1D4B; HNF4A; NR2F2; RXRBB
Function transcription factor activity, sequence-specific DNA binding
Related Protein PROX1; SLC26A3; UBN2B; ZKSCAN17; TULP4; REST; ZNF573; DMRTA2; RUNX1T1; SPI1B
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SOX9; SP1; NEUROG3; TFE3B; NKX2; FOXD1; FOS; ETV6; GABPA; NOBOX
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein KLF4; SOX10; CLOCK; MED12; LMO2; WWP2; NR1H4; KLF14; NFE2L1; CREB1
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein TCF21; ZFP536; BCL11AA; ZFPM2; ESRRA; NFIL3-5; ATF7; PPARA; TCF3; NFE2L3
Function ubiquitin conjugating enzyme binding
Related Protein ARIH1; RNF144A; TRAF6; ANKIB1A; DCUN1D5; RNF144AA; ZMYM2; UBE2V1; RNF180; RASD2
Function zinc ion binding
Related Protein VPS41; FNTB; RBM14B; FANCL; NR2F1A; MORC2B; RECQL4; BTR30; PHF15; FHL3

Interacting Protein

PPARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARA.
NCOR2; GRB2; CHD9; NCOR1; PIK3R3; UBE2I; PRMT2; MED1; LAMTOR5; RXRG; FOXA3; CDK3; PRMT1

PPARA Related Articles

Lu, Y; Liu, X; et al. Periostin promotes liver steatosis and hypertriglyceridernia through dovvnregulation of PPAR alpha. JOURNAL OF CLINICAL INVESTIGATION 124:3501-3513(2014).
Kienesberger, K; Pordes, AG; et al. L-carnitine and PPAR alpha-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cells. BMC GENOMICS 15:-(2014).