ppara
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  • Official Full Name
  • peroxisome proliferator-activated receptor alpha
  • Background
  • Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
  • Synonyms
  • PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1; MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferator activated receptor alpha; PPAR; PPAR-alpha; PPARA_HUMAN; PPARalpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha var
Cat.#:PPARA-1066HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA Protein, His-tagged
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Cat.#:PPARA-1083HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxisome Proliferator-activated Receptor Alpha
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Cat.#:PPARA-1084HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, GST-tagged
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Cat.#:PPARA-1085HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, LB Domain, 170-468aa
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Cat.#:PPARA-1086HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, LB Domain, GST-tagged
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Cat.#:PPARA-2740HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, His-tagged
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Cat.#:PPARA-113HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PPARA, GST-tagged
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Cat.#:PPARA-236HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human PPARA protein, His-tagged
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Cat.#:PPARA-28675THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA
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Cat.#:PPARA-29987THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA, His-tagged
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Cat.#:PPARA-318HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA protein, His/MBP-tagged
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Cat.#:PPARA-319HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARA protein, His/MBP-tagged
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Cat.#:Ppara-10MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppara protein, His-tagged
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Cat.#:PPARA-13160MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARA Protein
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Cat.#:PPARA-4592RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPARA Protein
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Cat.#:PPARA-3536RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPARA Protein, His-tagged
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Cat.#:PPARA-1107CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPARA
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Cat.#:PPARA-2987HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PPARA 293 Cell Lysate
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Involved Pathway

PPARA involved in several pathways and played different roles in them. We selected most pathways PPARA participated on our site, such as PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
LPL; ACOX3; ILK; GK2; FABP1; APOA5; SCDB; FABP7A; CYP4A14; APOA1A
cAMP signaling pathway
RAF1; OXTR; PAK1; HCN4; GRIA4; PTGER3; ATP1B2; PIK3CD; CNGA3; PLCE1
Adipocytokine signaling pathway
TNF; PRKAB1A; PRKAG2; STAT3; PCK2; ADIPOQB; ADIPOR2; CPT1C; PRKCQ; IRS2
Glucagon signaling pathway
CRTC2; SLC2A2; PPP3CA; CAMK2B; PRKAB2; SMEK2; PHKA1; PPP3R2; ACACA; AKT1
Insulin resistance
PTPN11; SLC2A2; INSB; GYS2; PPP1CAB; PDPK1; STAT3; PPARA; PRKCQ; PDPK1B
Non-alcoholic fatty liver disease (NAFLD)
NDUFA11; UQCR10; COX6A2; NDUFA4; NDUFA5; UQCRH; UQCRC2; IL6; UQCR11; NDUFB9
Hepatitis C
IFNA2; CLDN9; PIK3R5; PPP2R2D; PPP2R2C; MAPK11; IRF9; RAF1; CLDN23; IRF7

Protein Function

PPARA has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NFAT protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARA itself. We selected most functions PPARA had, and list some proteins which have the same functions with PPARA. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF560; ZFY2; SIX4A; ZNF511; ZNF131; CHTF8; IRX5A; CEBPZ; ASXL1; EZH2
Function MDM2/MDM4 family protein binding
Related Protein PSME3; CDKN2A; CDK5RAP3; CAV1; PPARA; RFWD3; TRP53
Function NFAT protein binding
Related Protein GATA4; PPARA; MAPK14; FOXP3; SPI1; SFPI1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ETS2; CEBPG; NFATC3; TFAM; SALL1; MAFA; AEBP2; MITFB; MED1; TBX15
Function RNA polymerase II repressing transcription factor binding
Related Protein DMAP1; BBS10; TTC8; PPARA; MKKS; SIN3A; MIXL1; MTA2; RBPJ; GATA6
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR2F6; NR2E3; NR2F6A; PPARDB; AHR2; NR1H4; RXRA; STAT3; RORCA; PPARA
Function drug binding
Related Protein HMGCS1; FOLR2; PPP3CA; PYGM; DRD1; CHRNB4; PDXK; CYP2D6; PDE4D; CHRNB2
Function lipid binding
Related Protein ACBD4; APOL1; VCP; CLINT1; BPIFB2; DOK7; ACBD6; UNC119; RASGRP2; BPIFB3
Function phosphatase binding
Related Protein SH3GL1; TPRN; MAST2; PPP1R26; TRPC4AP; DLG3; DZIP3; MAPK3; KLRAQ1; SMAD3
Function protein binding
Related Protein PTPRC; SNRPN; KIF2A; TBC1D20; AUP1; TMX3; PTH1R; KRTAP5-6; FBXO18; GSK3A
Function protein complex binding
Related Protein LRRC16A; LAMB3; FGFR1; DAG1; TUBB; NDUFA4; CCNE1; BCAP31; C8B; RIPK1
Function protein domain specific binding
Related Protein CALM1; HPCAL4; ZFP521; STXBP1; YWHAE1; SCAF1; DVL2; DYNLL1; CNTLN; NR0B2
Function sequence-specific DNA binding
Related Protein GSX1; ZFP110; NR3C2; MAFBA; HSF4; SLAMF7; NR2F6B; TSN; NR5A1A; HOXA4
Function steroid hormone receptor activity
Related Protein RORC; NR0B2A; NR1H3; NR2C1; RXRGA; NR1D2B; PAQR7B; RORCA; NR2F1B; VDRA
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATF6; MEOX2; ZIC3; ZNF207; ZNF571; HOXB4A; ELF2A; HOXB7; ESRRGB; SOX5
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein GATA2; TBX20; NOBOX; EBF4; PITX2; ZFAT; TXK; HIF1A; SMAD1; WT1
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein CLOCK; GBX2; NFE2L1; NOTCH1; KLF4; PPARA; CREB1; NKX2-5; JUN; NKX2
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MYPOP; HES1; OVOL1; TFAP2A; POU4F2; CC2D1B; HSF1; NACC2; GFI1; SFPI1
Function ubiquitin conjugating enzyme binding
Related Protein DCUN1D5; DCUN1D2; FOXL2; ZMYM2; RNF217; GRIK2; ARIH1L; RNF144AA; RNF144B; PPARA
Function zinc ion binding
Related Protein ZDHHC19; RBM4.2; MICAL1; RBM20; ALPP; FBXO11; ABLIM2; NUP153; TRIM48; CSRP1A

Interacting Protein

PPARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARA.
NCOR2; GRB2; CHD9; NCOR1; PIK3R3; UBE2I; PRMT2; MED1; LAMTOR5; RXRG; FOXA3; CDK3; PRMT1

PPARA Related Articles

Lu, Y; Liu, X; et al. Periostin promotes liver steatosis and hypertriglyceridernia through dovvnregulation of PPAR alpha. JOURNAL OF CLINICAL INVESTIGATION 124:3501-3513(2014).
Kienesberger, K; Pordes, AG; et al. L-carnitine and PPAR alpha-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cells. BMC GENOMICS 15:-(2014).