pparg
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  • Official Full Name
  • peroxisome proliferator-activated receptor gamma
  • Background
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;
Cat.#:PPARG-2602HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPARG Protein, MYC/DDK-tagged
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Cat.#:PPARG-1090HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, Ligand Binding Domain, His-tagged
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Cat.#:PPARG-1091HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, Ligand Binding Domain, GST-tagged
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Cat.#:PPARG-1872HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, GST-tagged
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Cat.#:PPARG-28670THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG
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Cat.#:PPARG-28671THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG
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Cat.#:PPARG-30104THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-31034THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-321HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG protein, His/MBP-tagged
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Cat.#:PPARG-4935HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxisome Proliferator-Activated Receptor Gamma, His-tagged
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Cat.#:PPARG-67HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-68HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, 1-477aa, His-tagged
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Cat.#:PPARG-7002HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPARG, His & GST tagged
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Cat.#:PPARG-13162MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARG Protein
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Cat.#:Pparg-39MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pparg protein, His-tagged
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Cat.#:PPARG-4593RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPARG Protein
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Cat.#:Pparg-7879RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pparg protein, His-tagged
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Cat.#:PPARG-804CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PPARG Protein, His-tagged
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Cat.#:PPARG-3537RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPARG Protein, His-tagged
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Cat.#:PPARG-1103CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPARG
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Cat.#:PPARG-7880RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit PPARG protein, His-tagged
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Cat.#:PPARG-9032ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPARG
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Cat.#:PPARG-7878CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle PPARG protein, His-tagged
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Cat.#:PPARG-2772HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, 209-477 aa, His-tagged
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Cat.#:PPARG-492HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPARG cell lysate
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Cat.#:CBCRY34Tag:
Source (Host):E. coliSpecies:
Product namePeroxisome Proliferator-activated Receptor Gamma
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Involved Pathway

PPARG involved in several pathways and played different roles in them. We selected most pathways PPARG participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
UCP1; FABP7B; ACSL1A; SCP2; FABP3; ACAA1A; GK2; PDPK1; ACSL3B; RXRAA
AMPK signaling pathway
AKT2; SCD5; AKT1; PPP2R5B; CD36; EEF2K; PPP2R2D; PPP2R1A; PIK3R5; PFKP
Osteoclast differentiation
GAB2; NFKBIA; PLCG2; FOSL1; PPP3CB; SIRP-BETA; MAP2K7; TGFB1; cgr2b; NCF2
Huntingtons disease
UQCRC1; NDUFB8; MT-ATP6; mt-Atp8; COX8C; SLC25A5; TBP; PPARG; IFT57; NDUFV1
Pathways in cancer
FGF2; EGLN2; GLI3; PIK3R3; BMP4; WNT2; PLCB2; CASP8; Fzd4; PRKCB
Transcriptional misregulation in cancer
WNT16; NFKBIZ; DEFA3; IGFBP3; CLSTN2; RUNX1T1; TAF15; FLT1; HIST1H3C; PAX8
Thyroid cancer
HRAS; KRAS; TFG; MAP2K2; LEF1; MAPK1; CCDC6; RET; TRP53; RXRG

Protein Function

PPARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARG itself. We selected most functions PPARG had, and list some proteins which have the same functions with PPARG. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NFYC; HIST1H2BH; POU3F3B; LMX1BA; KAT6B; HIST1H2AK; Arid4b; MKXA; EP300; PPP1R8
Function RNA polymerase II regulatory region DNA binding
Related Protein NCOA1; NKX2-1; PPARG; NPAS4; ATXN3L; TXK
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR5A1B; PPARAB; HNF4A; ESR2; RORCA; NR6A1; NR5A1A; NR2F1A; PPARAA; NR5A2
Function WW domain binding
Related Protein TCEAL2; SHISA5; TCEAL8; FAM189B; KIF20B; TRAF4; TCEAL7; TNK2; NFE2; PPARG
Function activating transcription factor binding
Related Protein PRDM16; SMAD2; DGKQ; HDAC7A; ATOH8; MEF2C; MEF2A; EEF1D; HDAC7; TAF9
Function alpha-actinin binding
Related Protein MAGI1; PKD2L1; XIRP2; MYOT; DAG1; LRRC10; KCNA5; RARA; ADORA2A; KCNN2
Function arachidonic acid binding
Related Protein CYP4A14; S100A9; S100A8; ALOX5AP; STX3; CYP4F14; PPARG
Function chromatin binding
Related Protein RING1; PRIMPOL; GLI1; CREBBP; HMGB2B; EWSR1A; WAC; PHF21B; POU5F3; ASF1A
Function core promoter sequence-specific DNA binding
Related Protein TRP53; GATA3; SOHLH1; ESR1; TOP1; PROX1; CREM; SOX4; RORA; CRY1
Function drug binding
Related Protein SETD6; ADRB2; NR1I2; SFRP1; CHRM3; RARB; CHRM1; P2RX2; PIGC; TLR8
Function enzyme binding
Related Protein GRIN1; AKIRIN2; MAP2K7; TSPAN10; KDM4C; ZNF346; C2orf56; ADORA2A; PHKG2; CBX4
Function estrogen receptor binding
Related Protein FOXL2; DYX1C1; TAF10; TRIP4; DDX17; TMEM38A; CCDC62; HSD17B10; PPARGC1B; ARRB1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein RBM14; AASS; KDM1A; HELZ2; ENY2; DCAF6; ATXN7L3; CALCOCO1; THRAP3; CCAR1
Function metal ion binding
Related Protein GALNS; SMYD2; MOXD1L; ZNF671; NT5DC3; ACVR2AA; ZFP830; THAP6; ZFP474; ATF7B
Function protein binding
Related Protein PSG5; FBXO44; C11orf57; AZU1; FAM81B; HYLS1; SYT11; MPP2; CRYBA2; HSPB1
Function protein phosphatase binding
Related Protein RPA2; ANAPC5; RPA3; ANAPC7; JUP; EGFR; JAK3; CDC27; STAT6; PPARG
Function retinoid X receptor binding
Related Protein RARG; NR1H2; VDR; NCOR1; FUS; PPARG; RARB; HMGA1; NRIP1; NSD1
Function contributes_to sequence-specific DNA binding
Related Protein FIGLA; PPARG; ARNT; SMAD4; HIF1A; TRIM28; EPAS1; NEUROD1; HDAC4; HNRNPAB
Function steroid hormone receptor activity
Related Protein THRB; HNF4A; NR4A2A; VDRB; RXRA; NR1H2; NR2C1; RORCA; NR0B2; PPARAA
Function transcription factor activity, sequence-specific DNA binding
Related Protein HES1; TCEAL1; PA2G4; E4F1; RORAA; TSC22D3; E2F5; TFDP1; KLF4; PA2G4A
Function transcription factor binding
Related Protein JUND; KAT8; TFDP1; GTF2A1; SOST; HEY1; ATF7; UBN1; H2-AB1; FOXA2
Function transcription regulatory region DNA binding
Related Protein SOX17; HIVEP2; RELA; REST; HINFP; RFX3; CCNT1; SP1; ZNF821; ZFP746
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein BARHL1A; RFX6; PAX9; GATA1; STAG1; BARHL1B; BARHL2; OSR2; BARX2; IRF2
Function zinc ion binding
Related Protein FTR67; UQCRC1; SEC23A; ZNF8; RNF34B; DTNB; MARCH9; TRIM40; LHX2A; ADAMTSL3

Interacting Protein

PPARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARG.
Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene

PPARG Related Articles

Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
Oysyannikova, IG; White, SJ; et al. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. VACCINE 32:881-887(2014).