PPARG Protein, peroxisome proliferator-activated receptor gamma


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Official Full Name peroxisome proliferator-activated receptor gamma
Background This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Synonyms PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPARG-1090H Recombinant Human PPARG, Ligand Binding Domain, His-tagged E.coli His
    Human PPARG-1091H Recombinant Human PPARG, Ligand Binding Domain, GST-tagged E.coli GST
    Human PPARG-1872H Recombinant Human PPARG, GST-tagged E.coli GST
    Human PPARG-2602H Recombinant Human PPARG Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PPARG-2772H Recombinant Human PPARG, 209-477 aa, His-tagged E.coli His
    Human PPARG-28670TH Recombinant Human PPARG E.coli N/A
    Human PPARG-28671TH Recombinant Human PPARG E.coli N/A
    Human PPARG-30104TH Recombinant Human PPARG, His-tagged E.coli His
    Human PPARG-31034TH Recombinant Human PPARG, His-tagged E.coli His
    Human PPARG-321H Recombinant Human PPARG protein, His/MBP-tagged E.coli His/MBP
    Human PPARG-492HCL Recombinant Human PPARG cell lysate Insect Cell N/A
    Human PPARG-4935H Recombinant Human Peroxisome Proliferator-Activated Receptor Gamma, His-tagged E.coli His
    Human PPARG-67H Recombinant Human PPARG, His-tagged E.coli HIS
    Human PPARG-68H Recombinant Human PPARG, 1-477aa, His-tagged E.coli His
    Human PPARG-7002H Recombinant Human PPARG, His & GST tagged Insect Cell His/GST
    Mouse PPARG-13162M Recombinant Mouse PPARG Protein Mammalian Cell His
    Mouse Pparg-39M Recombinant Mouse Pparg protein, His-tagged E.coli His
    Rat PPARG-4593R Recombinant Rat PPARG Protein Mammalian Cell His
    Rat Pparg-7879R Recombinant Rat Pparg protein, His-tagged E.coli His
    Cynomolgus Monkey PPARG-804C Recombinant Cynomolgus PPARG Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PPARG-3537R Recombinant Rhesus monkey PPARG Protein, His-tagged Mammalian Cell His
    Chicken PPARG-1103C Recombinant Chicken PPARG Mammalian Cell His
    Rabbit PPARG-7880R Recombinant Rabbit PPARG protein, His-tagged E.coli His
    Zebrafish PPARG-9032Z Recombinant Zebrafish PPARG Mammalian Cell His
    Cattle PPARG-7878C Recombinant Cattle PPARG protein, His-tagged E.coli His
    CBCRY34 Peroxisome Proliferator-activated Receptor Gamma E.coli N/A

    PPARG involved in several pathways and played different roles in them. We selected most pathways PPARG participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PPAR signaling pathway FABP7; ACADL; ANGPTL4; PPARD; FABP7A; RXRA; SCD5; SLC27A4; MMP1A; ACSL3A
    AMPK signaling pathway AKT3; STK11; PPP2R3A; CAB39L; RPS6KB1; Scd1; PPP2CA; SIRT1; PPARG; FASN
    Osteoclast differentiation NFKBIA; CYBB; TNF; AKT1; GRB2; LILRA4; IKBKG; MAPK3; PIK3R1; FCGR4
    Huntingtons disease NDUFB1; SP1; CREB3L3; POLR2I; GRM5; POLR2F; DNALC1; NDUFS2; POLR2H; UQCRH
    Pathways in cancer WNT3A; PRKCB; GNG3; NOS2; BIRC3; FGF2; BIRC8; HGF; EGLN1; MAX
    Transcriptional misregulation in cancer H3F3C; BMP2K; CDK14; DDX5; EWSR1; Bcl2a1b; GOLPH3L; RXRG; ZBTB16; PER2
    Thyroid cancer CDH1; CCDC6; TCF7L2; LEF1; RXRG; TP53; MAPK3; TFG; TCF7; PAX8

    PPARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARG itself. We selected most functions PPARG had, and list some proteins which have the same functions with PPARG. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region DNA binding NCOA1; TXK; NPAS4; NKX2-1; ATXN3L; PPARG
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR2F6B; RXRB; NR0B1; RORAB; NR1H3; NR5A1; PPARA; ESR2; ESRRA; NR1H2
    WW domain binding WBP11; TRP63; TCEAL2; TCEAL6; TCEAL8; DAZAP2; SCNN1B; TCEAL1; PPARG; TP63
    activating transcription factor binding HDAC7; ATOH8; RELA; GATA4; DGKQ; MEF2D; PSIP1; HDAC1; TAF9; MEF2C
    alpha-actinin binding RARA; PPARG; ADORA2A; ALMS1; KCNA5; KCNN2; XIRP2; LRRC10; DAG1; MAGI1
    arachidonic acid binding PPARG; S100A8; STX3; CYP4F14; ALOX5AP; S100A9; CYP4A14
    chromatin binding NFIA; FLI1; UXT; UBTFL; SUV39H1; TRIM24; PCNA; TFAP2A; UBTF; PRDM13
    core promoter sequence-specific DNA binding PROX1; ZFP750; GATA3; SOHLH2; CHD2; PRMT5; MEOX1; NFYA; ESR2; SOHLH1
    drug binding RARB; CYP2D6; FABP1; PYGB; ABP1; CHRNA3; MT2A; PPARD; PPARG; CYP4B1
    enzyme binding PDE4D; BCR; CCDC99; FOXO4; CTNNB1; P4HB; TULP3; PPP1R3D; AKIRIN2; ITGB3
    estrogen receptor binding CTNNB1; TMEM38A; HSD17B10; PPARGC1A; TAF10; LEF1; NCOA1; XBP1; DDX17; PCNA
    ligand-dependent nuclear receptor transcription coactivator activity RBM14; PUS1; PPARGC1A; DCAF6; MED4; HMGA1-RS1; TSG101; KDM1A; PSMC3IP; USP22
    metal ion binding MOBKL2A; ASAP3; LEPREL1; ZNF580; CA15B; METAP1; RRM2B; ZFP687; COL27A1A; ZFP106
    protein binding ARHGAP5; IL12A; VTI1B; C16orf45; SENP6; GPBP1; NUP62CL; HNRNPM; FKBP2; VPS4B
    protein phosphatase binding ITPR1; ANAPC5; HSF4; VCP; DRD1A; PPARG; KCNN4; DLG4; PPME1; MVP
    retinoid X receptor binding HMGA1; NSD1; HMGA1-RS1; NR1H2; NR0B2; VDR; NR1H4; NCOR1; NCOA1; RARB
    contributes_to sequence-specific DNA binding ARNT; PPARG; FIGLA; EPAS1; HNRNPAB; TRIM28; TCF3; NEUROD1; HDAC4; HIF1A
    steroid hormone receptor activity RORAA; RXRB; NR2E1; RORAB; PGRMC2; NR2F6; NR1D2; NR6A1B; NR6A1; RARGA
    transcription factor activity, sequence-specific DNA binding RFX3; NFYA; NFE2; ZNF394; REST; NFE2L1B; HOXC4A; FOSL2; MAFBA; ATF4B2
    transcription factor binding STAT3; HMGA2; BRD7; APBB2; TP73; UBA2; PRKDC; TNFRSF10A; NFATC3; FOXO1
    transcription regulatory region DNA binding TAF2; ZNF174; CDK9; ATF6B; KCNA3; FOS; ATF4; Ar; RELA; HIVEP3
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DMRT1; EAF2; AIRE; GATA3; SOX17; GATA2B; MAFGA; ATF3; GATA4; PAX9
    zinc ion binding NEURL1AA; EHMT1B; PIAS4; DTNBA; ARIH1L; RNF135; MEP1B; LHX5; CHORDC1; MAN2B2

    PPARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARG.

    Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene

    Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
    Oysyannikova, IG; White, SJ; et al. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. VACCINE 32:881-887(2014).

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