pparg
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  • Official Full Name
  • peroxisome proliferator-activated receptor gamma
  • Background
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;
Cat.#:PPARG-2602HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPARG Protein, MYC/DDK-tagged
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Cat.#:PPARG-1090HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, Ligand Binding Domain, His-tagged
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Cat.#:PPARG-1091HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, Ligand Binding Domain, GST-tagged
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Cat.#:PPARG-1872HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, GST-tagged
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Cat.#:PPARG-28670THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG
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Cat.#:PPARG-28671THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG
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Cat.#:PPARG-30104THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-31034THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-321HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG protein, His/MBP-tagged
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Cat.#:PPARG-4935HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxisome Proliferator-Activated Receptor Gamma, His-tagged
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Cat.#:PPARG-67HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-68HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, 1-477aa, His-tagged
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Cat.#:PPARG-7002HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPARG, His & GST tagged
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Cat.#:PPARG-13162MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARG Protein
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Cat.#:Pparg-39MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pparg protein, His-tagged
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Cat.#:PPARG-4593RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPARG Protein
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Cat.#:Pparg-7879RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pparg protein, His-tagged
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Cat.#:PPARG-804CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PPARG Protein, His-tagged
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Cat.#:PPARG-3537RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPARG Protein, His-tagged
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Cat.#:PPARG-1103CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPARG
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Cat.#:PPARG-7880RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit PPARG protein, His-tagged
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Cat.#:PPARG-9032ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPARG
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Cat.#:PPARG-7878CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle PPARG protein, His-tagged
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Cat.#:PPARG-2772HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, 209-477 aa, His-tagged
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Cat.#:PPARG-492HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPARG cell lysate
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Cat.#:CBCRY34Tag:N/A
Source (Host):E. coliSpecies:
Product namePeroxisome Proliferator-activated Receptor Gamma
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Involved Pathway

PPARG involved in several pathways and played different roles in them. We selected most pathways PPARG participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
APOA1A; ACSL3; Scd1; ACADM; CYP8B1; PPARDB; SCD5; SLC27A4; ACSL1B; PPARG
AMPK signaling pathway
G6PC2; G6PC3; Scd2; LIPE; HNF4A; PIK3R5; AKT1S1; FASN; FOXO1; IGF1R
Osteoclast differentiation
SQSTM1; NFKBIA; MAP2K6; MAPK1; AKT2; TREM2; LILRB5; SIRPA; TGFBR1; LILRA4
Huntingtons disease
TGM2; DCTN1; UQCRFS1; ATP5G3; COX7B2; ATP5H; mt-Atp8; COX6C; DNAL4; COX5A
Pathways in cancer
TRAF1; NFKB1; CBLC; Flt3l; GNAI3; BID; HGF; KRAS; CXCL12; CDC42
Transcriptional misregulation in cancer
LYL1; FCGR1; LRP2BP; Aff1; RUNX1T1; PTK2; FUT8; FUS; PLAU; BIRC3
Thyroid cancer
CCND1; RXRG; MAP2K2; RXRA; NRAS; HRAS; NTRK1; RXRB; MAPK1; MAPK3

Protein Function

PPARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARG itself. We selected most functions PPARG had, and list some proteins which have the same functions with PPARG. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP654; HYPM; BRPF1; PNN; ZFP593; ZNF703; DNTT; HNF1A; FEZF1; DNA2
Function RNA polymerase II regulatory region DNA binding
Related Protein NCOA1; ATXN3L; NKX2-1; TXK; PPARG; NPAS4
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein STAT3; HNF4A; RORA; RORAB; NR5A1B; NR1H2; ESRRB; NR2F1B; NR5A2; AHR2
Function WW domain binding
Related Protein TP63; TCEAL8; TCEAL2; DAZAP2; WBP5; WBP11; TMEM128; TCEAL1; TNK2; PMEPA1
Function activating transcription factor binding
Related Protein GATA4; HDAC1; DGKQ; MEF2C; SMAD2; ZFP516; PRDM16; MEF2D; PPARG; RELA
Function alpha-actinin binding
Related Protein RARA; KCNN2; XIRP2; KCNA5; MAGI1; ADORA2A; PPARG; PKD2L1; MYOT; LRRC10
Function arachidonic acid binding
Related Protein S100A8; ALOX5AP; CYP4A14; CYP4F14; PPARG; STX3; S100A9
Function chromatin binding
Related Protein TOP1; WHSC1; HDGF2; SUZ12; PRDM13; PATZ1; TCF7L2; FOXC1A; MSGN1; BARX2
Function core promoter sequence-specific DNA binding
Related Protein SOHLH2; NR4A3; MEOX1; TP53; SIRT1; GATA3; ZFHX3; TOP1; NRIP1; TRP53
Function drug binding
Related Protein ATP5O; MT3; PDE2A; PPARG; FOLR1; PDE4D; MT2A; CHRNA2; DRD1; DRD3
Function enzyme binding
Related Protein STC2; LGALS9; HMOX1; HNRNPUL1; PLSCR4; PDE4DIP; ARRB2; ZNHIT6; DNM2; H2AFX
Function estrogen receptor binding
Related Protein PHB2; ARRB1; NKX3-1; TMEM38A; DYX1C1; STRN; XBP1; PPID; PPARG; WIPI1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED4; MED24; BUD31; HELZ2; CCAR1; PUS1; MED14; PPARG; ATXN7L3; RBM14
Function metal ion binding
Related Protein NR4A2B; PHLPP2; FYCO1; ZNF410; DDX11; CAT; ARG2; ZNF544; PLRDGB; ACAP1
Function protein binding
Related Protein ALOX12B; NEK2; DUSP1; GTF3C4; TAF1; HOXB7; PDXP; HLTF; RBM17; CISD2
Function protein phosphatase binding
Related Protein IRS2; PPME1; GRB2; STAT6; JUP; PPP1R3C; EGFR; STAT3; GNB2L1; JUPA
Function retinoid X receptor binding
Related Protein NR1H4; RARG; NCOR1; NCOA1; RARB; PPARG; HMGA1; NR4A2; HMGA1-RS1; NSD1
Function contributes_to sequence-specific DNA binding
Related Protein EPAS1; HIF1A; FIGLA; ARNT; PPARG; SMAD4; TCF3; NEUROD1; HDAC4; TRIM28
Function steroid hormone receptor activity
Related Protein PPARAB; NR1D4B; ESR2B; RXRA; RARGB; RARA; NR1H3; RXRG; NR6A1; OLFR78
Function transcription factor activity, sequence-specific DNA binding
Related Protein RXRBB; SP1; TBX1; ZFP518A; FOXA2; ENO1; IRF1A; ZNF311; KLF10; ZNF565
Function transcription factor binding
Related Protein KEAP1B; POU1F1; PSMD10; TP53; HES2; PPARG; HDAC8; HHEX; FOXC1; JUNB
Function transcription regulatory region DNA binding
Related Protein GATA3; ZFP513; ZNF567; ZFP382; NR1H3; SOX7; MEF2C; TBL1XR1; Ar; ATF5
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein PPARG; FOXF2; SOHLH1; EP300; HSF2; NKX2-5; GLIS1; CTCF; SLAMF7; MYOG
Function zinc ion binding
Related Protein ZCCHC9; RNF139; RFPL1; UBR7; TIMM9; RNF150; DRP2; PDLIM4; TRIM35-27; AQPEP

Interacting Protein

PPARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARG.
Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene

PPARG Related Articles

Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
Oysyannikova, IG; White, SJ; et al. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. VACCINE 32:881-887(2014).