pparg
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  • Official Full Name
  • peroxisome proliferator-activated receptor gamma
  • Background
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;
Cat.#:PPARG-2602HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPARG Protein, MYC/DDK-tagged
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Cat.#:PPARG-1090HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, Ligand Binding Domain, His-tagged
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Cat.#:PPARG-1091HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, Ligand Binding Domain, GST-tagged
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Cat.#:PPARG-1872HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, GST-tagged
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Cat.#:PPARG-28670THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG
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Cat.#:PPARG-28671THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG
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Cat.#:PPARG-30104THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-31034THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-321HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG protein, His/MBP-tagged
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Cat.#:PPARG-4935HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxisome Proliferator-Activated Receptor Gamma, His-tagged
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Cat.#:PPARG-67HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, His-tagged
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Cat.#:PPARG-68HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, 1-477aa, His-tagged
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Cat.#:PPARG-7002HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPARG, His & GST tagged
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Cat.#:PPARG-13162MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARG Protein
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Cat.#:Pparg-39MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pparg protein, His-tagged
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Cat.#:PPARG-4593RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPARG Protein
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Cat.#:Pparg-7879RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pparg protein, His-tagged
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Cat.#:PPARG-804CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PPARG Protein, His-tagged
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Cat.#:PPARG-3537RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPARG Protein, His-tagged
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Cat.#:PPARG-1103CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPARG
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Cat.#:PPARG-7880RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit PPARG protein, His-tagged
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Cat.#:PPARG-9032ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPARG
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Cat.#:PPARG-7878CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle PPARG protein, His-tagged
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Cat.#:PPARG-2772HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARG, 209-477 aa, His-tagged
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Cat.#:PPARG-492HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPARG cell lysate
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Cat.#:CBCRY34Tag:
Source (Host):E. coliSpecies:
Product namePeroxisome Proliferator-activated Receptor Gamma
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Involved Pathway

PPARG involved in several pathways and played different roles in them. We selected most pathways PPARG participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
PDPK1B; ACADL; SLC27A2; SCD5; FABP1; MMP1; HMGCS2; ANGPTL4; ACAA1; ACSL3
AMPK signaling pathway
RAB10; PIK3CG; PPP2R5C; PFKFB1; PIK3R1; HNF4A; CPT1B; Scd2; CAMKK2; ACACA
Osteoclast differentiation
TEC; CALCR; NOX1; LILRA5; NCF2; PIK3CA; TNF; MAPK11; IFNAR1; RAC1
Huntingtons disease
SLC25A31; COX6A1; NDUFB10; NDUFB7; COX7C; PLCB3; NDUFA1; GRIN1; VDAC3; ATP5G3
Pathways in cancer
WNT3A; STK4; TRAF1; HDAC1; TFG; MMP1A; PLCG2; MSH2; RASSF1; TGFBR1
Transcriptional misregulation in cancer
Itgam&Itgb2; IL2RB; ASPSCR1; PTCRA; TCF3; MEF2C; ETV7; LYL1; NGFR; EYA1
Thyroid cancer
TCF7; TPM3; NTRK1; TRP53; HRAS; PPARG; CCDC6; KRAS; TP53; BRAF

Protein Function

PPARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARG itself. We selected most functions PPARG had, and list some proteins which have the same functions with PPARG. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein PCBP3; GATA4; PGR; MBD1B; TET3; SMAD6A; GTF2E2; C1D; TBL1XR1; ZFP653
Function RNA polymerase II regulatory region DNA binding
Related Protein ATXN3L; NPAS4; NCOA1; PPARG; NKX2-1; TXK
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein STAT3; NR1I2; RXRA; NR2F5; NR1H3; PPARDB; NR0B1; HNF4A; RORA; VDRA
Function WW domain binding
Related Protein PMEPA1; WBP11; TCEAL7; SCNN1G; TRP63; TCEAL6; TCEAL1; SHISA5; TCEAL8; TCEAL5
Function activating transcription factor binding
Related Protein MEF2C; MEF2D; SMAD2; TAF9; MEF2A; PPARG; EEF1D; GATA4; EP300; DGKQ
Function alpha-actinin binding
Related Protein KCNA5; MAGI1; XIRP2; RARA; LRRC10; ALMS1; MYOT; KCNN2; ADORA2A; DAG1
Function arachidonic acid binding
Related Protein STX3; PPARG; S100A9; CYP4A14; ALOX5AP; S100A8; CYP4F14
Function chromatin binding
Related Protein DNMT1; ZGLP1; CTBP2; EZH2; JUB; MCM5; GPR30; NCOA3; ATF2; LDB2A
Function core promoter sequence-specific DNA binding
Related Protein TP53; MTA1; SOHLH1; NRIP1; MYOCD; CHD2; ZFHX3; GATA3; THRAP3; NFYA
Function drug binding
Related Protein PPP3CB; ADRB2; Alb; PYGM; SRP54B; PYGB; FSCN1; MT3; CHRM2; PDE4D
Function enzyme binding
Related Protein PTPLA; CYB5A; TSPAN14; ITGB3; HIST1H2AL; PLCE1; SCN5A; UBE2I; LUC7L2; DIS3L
Function estrogen receptor binding
Related Protein PHB2; PPARGC1B; NRIP1; XBP1; CNOT1; MMS19; PCNA; PPID; STRN; PADI2
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED14; PPRC1; FGF2; TSG101; PUS1; NCOA2; SMARCD3; PPARGC1B; USP22; PKN1
Function metal ion binding
Related Protein ZNF683; GALNT6; ZFP106; TEC; STK25; ZSCAN4; ZC3H7A; AEBP2; ZNF831; EPT1
Function protein binding
Related Protein ZNHIT6; ATF7IP; POU2AF1; CSTF2; MAP3K9; AGR2; ALK; KLRD1; FAM154A; HACE1
Function protein phosphatase binding
Related Protein DLG3; CSF1R; JAK3; ERBB2; STAT3; SNX3; FLT4; CTNNB1; JUP; HSP90B1
Function retinoid X receptor binding
Related Protein VDR; NR0B2; PPARG; RARG; FUS; NR4A2; RARB; NRIP1; NR1H4; HMGA1
Function contributes_to sequence-specific DNA binding
Related Protein FIGLA; TRIM28; ARNT; TCF3; NEUROD1; EPAS1; HNRNPAB; SMAD4; HIF1A; PPARG
Function steroid hormone receptor activity
Related Protein OLFR78; NR1H2; RXRG; NR5A2; NR1D2; THRAA; RARA; OR51E2; RARAA; PPARAB
Function transcription factor activity, sequence-specific DNA binding
Related Protein TCF3A; YBX1; KLF10; IRF3; RERE; ZNF286A; PAX6; ESRRGB; FOXP4; TBX1
Function transcription factor binding
Related Protein HDAC5; RPS3; FOXF2; PIK3R1; DDIT3; TP53; TLE1; CTBP1; Ar; FOXO4
Function transcription regulatory region DNA binding
Related Protein SALL2; BCL11AA; MTERF3; KLF15; PAX2; TAF2; ZNF821; ATMIN; TAF7; MLL1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein GATA5; TRPS1; SOHLH2; BARHL1A; GATA4; CSRNP3; RXRB; SOX17; MYOD1; OSR2
Function zinc ion binding
Related Protein ANPEP; NR3C1; PHF20B; TOPORS; RNF133; BRCA1; TLL1; SLC25A46; CA12; KDM5D

Interacting Protein

PPARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARG.
Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene

PPARG Related Articles

Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
Oysyannikova, IG; White, SJ; et al. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. VACCINE 32:881-887(2014).