Recombinant Human PPARG Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | PPARG-5244H |
Product Overview : | PPARG MS Standard C13 and N15-labeled recombinant protein (NP_005028) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 54.7 kDa |
AA Sequence : | MTMVDTEMPFWPTNFGISSVDLSVM EDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEYQ SAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYGV HACEGCKGFFRRTIRLKLIYDRCDL NCRIHKKSRNKCQYCRFQKCLAVGM SHNAIRFGRMPQAEKEKLLAEISSD IDQLNPESADLRALAKHLYDSYIKS FPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSK EVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEI IYTMLASLMNKDGVLISEGQGFMTR EFLKSLRKPFGDFMEPKFEFAVKFN ALELDDSDLAIFIAVIILSGDRPGL LNVKPIEDIQDNLLQALELQLKLNH PESSQLFAKLLQKMTDLRQIVTEHV QLLQVIKKTETDMSLHPLLQEIYKD LYTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens (human) ] |
Official Symbol : | PPARG |
Synonyms : | PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1; GLM1; CIMT1; |
Gene ID : | 5468 |
mRNA Refseq : | NM_005037 |
Protein Refseq : | NP_005028 |
MIM : | 601487 |
UniProt ID : | P37231 |
Products Types
◆ Recombinant Protein | ||
PPARG-1741H | Recombinant Human PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
PPARG-3355R | Recombinant Rhesus Macaque PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
PPARG-547C | Recombinant Cynomolgus Monkey PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
Pparg-5030M | Recombinant Full Length Mouse Pparg Protein, Myc/DDK-tagged | +Inquiry |
PPARG-4935H | Recombinant Human PPARG Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PPARG-492HCL | Recombinant Human PPARG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt was reassuring to use a product that adhered to green chemistry principles, reducing our impact on the environment.
The company's dedication to environmental sustainability reflected positively on the product and our research initiatives.
We appreciated the option to request modifications or custom formulations to meet our project's requirements.
Q&As (7)
Ask a questionPPARG has two isoforms, PPARG1 (57 kDa) and PPARG2, a splice variant with an additional 30 amino acids at the N-terminus.
PPARG has two isoforms with molecular weights of 57 kDa and 54 kDa. Modified PPARG is about 67 kDa.
PPARG stands for Peroxisome Proliferator-Activated Receptor Gamma.
Yes, experimental data suggests a 45 kDa protein immunologically related to PPARG, called mt-PPAR, is located in mitochondria. Its molecular weight is less than PPARG2.
PPARG is a ligand-activated transcription factor that plays a crucial role in regulating lipid homeostasis, adipogenesis, insulin resistance, and organ development.
Defects in PPARG are associated with familial partial lipodystrophy type 3 (FPLD3), susceptibility to obesity, type 2 insulin-resistant diabetes, hypertension, and colon cancer.
PPARG is mainly localized in the nucleus, although it can also be detected in the cytoplasm, exhibiting extra-nuclear/non-genomic actions in certain contexts.
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