PPP1R8 Protein, protein phosphatase 1, regulatory subunit 8


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Official Full Name protein phosphatase 1, regulatory subunit 8
Background This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Synonyms PPP1R8; protein phosphatase 1, regulatory subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; nuclear inhibitor of protein phosphatase 1; activator of RNA decay; ard 1; ARD1; NIPP 1; NIPP1; nuclear subunit of PP 1; PRO2047; protein phospha
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ppp1r8-026M Recombinant Mouse Ppp1r8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human PPP1R8-2143H Recombinant Human PPP1R8 Protein (1-209 aa), GST-tagged E.coli GST
    Human PPP1R8-26964TH Recombinant Human PPP1R8 Wheat Germ N/A
    Human PPP1R8-2931HCL Recombinant Human PPP1R8 293 Cell Lysate HEK293 N/A
    Human PPP1R8-2932HCL Recombinant Human PPP1R8 293 Cell Lysate HEK293 N/A
    Rhesus Macaque PPP1R8-3569R Recombinant Rhesus monkey PPP1R8 Protein, His-tagged Mammalian Cell His
    Chicken PPP1R8-2580C Recombinant Chicken PPP1R8 Mammalian Cell His

    PPP1R8 involved in several pathways and played different roles in them. We selected most pathways PPP1R8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PPP1R8 has several biochemical functions, for example, DNA binding, RNA binding, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R8 itself. We selected most functions PPP1R8 had, and list some proteins which have the same functions with PPP1R8. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding IRX5B; SMG6; HOXC13; PAX2A; AHCTF1; ZNF688; POLD2; ZNF559-ZNF177; HIST2H4A; RORAB
    endonuclease activity RNASE4; MRE11A; PNKP; EAR14; EAR2; RNASE6; RNASE3; ZC3H12A; ENDOG; EAR4
    protein binding PRDM13; RNF115; ADAM10; TMEM115; ZNF404; RAD23A; COPS8; CUEDC2; ATF7; FBXL15
    protein phosphatase type 1 regulator activity PPP1R16A; PHACTR3A; PHACTR3; PPP1R15A; KCNS1; PPP1R7; UBXN2A; PHACTR3B; PPP1R8; NSFL1C
    protein serine/threonine phosphatase inhibitor activity PPP1R14C; PPP1R11; PPP1R1C; PPP1R1A; PPP1R8; PPP1R17
    ribonuclease E activity PPP1R8

    PPP1R8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R8.


    Klein, AL; Berkaw, MN; et al. O-Linked N-Acetylglucosamine Modification of Insulin Receptor Substrate-1 Occurs in Close Proximity to Multiple SH2 Domain Binding Motifs. MOLECULAR & CELLULAR PROTEOMICS 8:2733-2745(2009).
    Lindenthal, C; Klinkert, MQ; et al. Identification and biochemical characterisation of a Protein Phosphatase 5 homologue from Plasmodium falciparum. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 120:257-268(2002).
    Pfitzer, G; Sonntag-Bensch, D; et al. Thiophosphorylation-induced Ca2+ sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase. JOURNAL OF PHYSIOLOGY-LONDON 533:651-664(2001).
    Lengyel, I; Nichol, KA; et al. Characterization of protein kinase and phosphatase systems in chick ciliary ganglion. NEUROSCIENCE 70:577-588(1996).

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