The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).
PRAM1 has several biochemical functions, for example, lipid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRAM1 itself. We selected most functions PRAM1 had, and list some proteins which have the same functions with PRAM1. You can find most of the proteins on our site.
Function lipid binding
Related Protein RBP7B; FAM123A; APOE; PSAP; APOA1B; ZFYVE26; CLINT1; Fert2; STARD7; APOC2
Function protein binding
Related Protein CIC; EPS15L1; KCNJ10; DIABLO; SDCCAG8; MAX; GPS1; FZD5; ZMYND10; CDK4
PRAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRAM1.