prdm1
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  • Official Full Name
  • PR domain containing 1, with ZNF domain
  • Background
  • This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically;to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases;upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
  • Synonyms
  • PRDM1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; B lymphocyte induced maturation protein; B lymphocyte-induced maturation protein 1; beta-interferon gene positive regulatory domain I-binding factor; Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1
Cat.#:PRDM1-1758HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRDM1 protein, His-tagged
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Cat.#:PRDM1-13309MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRDM1 Protein
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Cat.#:Prdm1-1928MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prdm1 protein, His & T7-tagged
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Cat.#:Prdm1-1929RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prdm1 protein, His & T7-tagged
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Cat.#:PRDM1-2887HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRDM1 293 Cell Lysate
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Cat.#:PRDM1-2890HCLTag:Flag
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human PR domain containing 1 cell lysate, transcript variant 2
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Cat.#:PRDM1-2891HCLTag:Flag
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human PR domain containing 1 cell lysate, transcript variant 1
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Involved Pathway

PRDM1 involved in several pathways and played different roles in them. We selected most pathways PRDM1 participated on our site, such as Direct p53 effectors, NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Direct p53 effectors
PRDM1; CSE1L; SCN3B; BNIP3L; FOXA1; TRIAP1; CEBPZ; BCL2L14; GDF15; DDX5
NOD pathway
COPS6; NLRP7; NLRP4; SUGT1; NLRP10; NLRP12; NLRP2; PRDM1; AAMP; NLRP3

Protein Function

PRDM1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, histone deacetylase binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM1 itself. We selected most functions PRDM1 had, and list some proteins which have the same functions with PRDM1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FOXI1; NR5A2; AEBP2; ZNF264; SIX1; NFAT5; MXD1; ELK3; CEBPA; RBPJB
Function histone deacetylase binding
Related Protein SUDS3; XBP1; CAMTA2; SIRT2; PHB; MYOCD; CEBPA; SKOR2; HES1; ANKRA2
Function metal ion binding
Related Protein NME6; XGB; ZKSCAN6; PAPD4; ZSCAN20; ZNF763; NCALDB; ZNF436; CYP2K6; ZXDC
Function methyltransferase activity
Related Protein SETD1B; SETDB1B; C2orf56; PRDM15; METTL13; PRDM1; PMT; SKINT8; DIMT1; METTL17
Function protein binding
Related Protein DDI1; EVLA; NIP7; CYFIP1; EIF4EBP1; FAM113B; NUMBL; CSNK2B; MT3; FHL5
Function transcription factor activity, sequence-specific DNA binding
Related Protein ALX1; TFDP1A; NR3C2; RFXAP; SMAD3B; TADA2A; SMAD6A; IKZF2; HSF4; POU5F2
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein RELA; SALL1; NKX3-2; SNAI2; HES1; ZKSCAN3; REST; SFPI1; NFIL3; HAND1

Interacting Protein

PRDM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM1.
PIAS1; HSP90AB1; SUMO1; CDC37; ATXN1; clpB; ifnl1_human_gene

PRDM1 Related Articles

Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

PRDM1 Related Gene Family

Cytokines