prkca
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  • Official Full Name
  • protein kinase C, alpha
  • Background
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PRKCA; protein kinase C, alpha; AAG6; PKCA; PRKACA; PKC-alpha; protein kinase C alpha type; PKC-A; aging-associated gene 6;
Cat.#:PRKCA-347HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRKCA
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Cat.#:PRKCA-398HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase C, Alpha, GST-tagged, Active
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Cat.#:PRKCA-58HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human protein kinase C, Alpha, His-tagged
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Cat.#:PRKCA-648HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Protein Kinase C, Alpha
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Cat.#:PRKCA-13361MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKCA Protein
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Cat.#:Prkca-1971MTag:His|S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prkca protein, His & S-tagged
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Cat.#:PRKCA-3604RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKCA Protein, His-tagged
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Cat.#:PRKCA-2032CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKCA
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Cat.#:PRKCA-8136ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKCA
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Cat.#:Prkca-397XTag:GST
Source (Host):Sf 9 Insect cellsSpecies:
Product nameRecombinant Xenopus Prkca, GST-tagged, Active
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Cat.#:PRKCA-1087HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase C, Alpha, GST-tagged
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Cat.#:PRKCA-1301HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Kinase C, Alpha, His-tagged
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Cat.#:PRKCA-499HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRKCA lysate
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Involved Pathway

Prkca involved in several pathways and played different roles in them. We selected most pathways Prkca participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkca were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PPP3R1B; MAP3K11; CACNB3A; CACNA1D; CACNB1; PPM1BB; MAP4K4; PRKACBA; RAC3A; PRKCG
ErbB signaling pathway
MAP2K2A; MAPK1; RAF1B; PIK3R1; MAP2K4; SRC; PIK3R3B; MAPK8A; PLCG1; CAMK2B
Ras signaling pathway
RIN1; FGFR2; INS2; KIT; FGF3; FGF8; FGF14; FGF16; PLA2G10; MET
Rap signaling pathway
FLT1; FARP2; FGFR3; MAPK3; SRC; MAP2K6; MLLT4; RAP1B; Itgam&Itgb2; CDH1
Calcium signaling pathway
TACR3A; ERBB3B; P2RX5; ATP2A2A; RYR2; CHRNA7; ERBB3A; PHKG1A; ITPKC; ATP2A1
HIF- signaling pathway
HMOX1; IL6R; VHL; PRKCA; HKDC1; HK1; INSR; TLR4; ENO1; TF
Phosphatidylinositol signaling system
PIP5K1BB; MTMR7A; MTMR14; IMPA1; PIP5K1AA; CALM3B; SYNJ1; PIK3C2G; PIP4K2AA; PIP5K2
Sphingolipid signaling pathway
NRAS; PPP2R2C; MS4A2; PIK3R1; LASS1; PRKCG; SGPL1; BCL2; PPP2R1B; AKT2
Phospholipase D signaling pathway
PLA2G4D; LPAR4; PIP5K1A; CXCR2; PLCB4; RAF1; AKT1; GRM4; FYN; PPAP2C
mTOR signaling pathway
PRKCG; MAPK3; MLST8; PIK3CD; TSC1; AKT1; RRAGD; EIF4E2; AKT2L; MTOR
PIK-Akt signaling pathway
FGF20; PCK2; IFNA6; INS1; PRLR; GNB3; IL3; IKBKB; Il4ra; PPP2R5E
Adrenergic signaling in cardiomyocytes
CREB1A; ADRA1BB; MYH7; ATF4B1; ADCY3; CALM2A; CAMK2D1; PPP2R5B; ATP1B3; CREM
Vascular smooth muscle contraction
PRKACAA; CACNA1SA; KCNMB1; CALM2B; GNA11A; ADORA2AA; GNAQ; CALM2; PRKG1A; RHOAD
Wnt signaling pathway
FZD8A; NKD2; FBXW11A; TLE3A; PPARDB; VANGL2; NLK1; BTRC; MMP7; CER1
VEGF signaling pathway
MAP2K1; HRASA; PIK3R3A; PTK2; PIK3R5; MAPK12; PRKCB; SHC2; PLA2G4F; PPP3R2
Focal adhesion
BCL2A; CAV2; PIK3CG; RHOAC; SEPP1; VASPA; MAPK8; THBS4B; PAK6B; CAV3
Tight junction
ACTN2; SHROOM3; PARD6A; PRKCA; EXOC4; MAGI2; MPDZ; PRKCZ; CRB3; CSNK2A2A
Gap junction
HTR2A; TUBA8L2; TUBB2B; GJA1; MAP2K2; PRKG1; Pdgfa&Pdgfb; GNAI2A; PRKCA; PLCB3
Natural killer cell mediated cytotoxicity
IFNA7; ICAM2; PPP3CA; MAP2K1; IFNG; RAC1; IFNGR1; RAET1D; ULBP3; LAT
Fc epsilon RI signaling pathway
PIK3R1; GRB2; PLA2G4C; FCER1A; IL4; VAV1; PLA2G4D; MAPK3; GAB2; FYN
Fc gamma R-mediated phagocytosis
PIK3R2; MAP2K1; VASP; SCIN; AKT1; BIN1; MARCKSL1; RPS6KB1; VAV1; MAPK1
Leukocyte transendothelial migration
RAP1B; CLDN1; CDH5; JAM3; ACTN2; ACTG1; ITGA4; NCF1; CLDN10; VAV1
Circadian entrainment
GNG4; PRKACA; GNG3; GNAQ; KCNJ9; CACNA1G; GRIA2; PLCB3; GNG12; GNAI3
Long-term potentiation
RPS6KA3; MAP2K2; PLCB1; RAP1B; PPP3CC; PPP3CA; NRAS; GRIN2D; EP300; GRIA2
Retrograde endocannabinoid signaling
PLCB1; GNAI1; GNB4; MAPK9; GABRR3; GNG8; PLCB2; GABRB2; MAPK8; GRIA4
Glutamatergic synapse
ADRBK2; GNB3; ITPR1; PLCB4; GRIK1; GRM6; PLD2; GNG4; PPP3CC; GRIN1
Cholinergic synapse
CREB3L3; ATF4; HRAS; CAMK2A; PLCB4; CREB5; PIK3CB; CAMK2D; PRKCG; KCNQ1
Serotonergic synapse
GABRB3; HTR2B; PLCB3; TRPC1; GNB1; NRAS; RAF1; HTR6; HTR3A; GNG13
GABAergic synapse
GABRA2; GNG13; GNGT2; GABARAPL1; GNG12; PRKCG; GABRR2; GLUL; GABRD; PRKACG
Dopaminergic synapse
KCNJ3; DDC; MAPK13; MAOA; PPP1CA; CREB3L1; CALY; PPP2R5E; PRKACB; CALM1
Long-term depression
PLCB2; PLA2G4F; ITPR3; GRIA2; PPP2CA; NOS1; IGF1; GRIA1; BRAF; PLA2G4C
Inflammatory mediator regulation of TRP channels
IGF1; CALM3; HTR2C; TRPV3; CAMK2G; PLA2G4D; MAP2K6; ITPR3; PPP1CC; CYP2C37
Insulin secretion
GIP; SLC2A1; INS1; KCNMB3; KCNN4; ATP1A3; SNAP25; GNAQ; GPR119; CCKAR
GnRH signaling pathway
LHB; MAPK12; MAPK14A; CAMK2D1; PLCB1; MAP2K2B; PLD1; PRKACG; MAP3K4; PRKCD
Melanogenesis
EDNRB2; WNT3A; PRKCBA; WNT16; CAMK2G; CALM3; POMCA; MAPK3; RAF1; DCT
Thyroid hormone synthesis
PLCB1; GPX3; GPX5; ASGR2; SLC26A4; HSP90B1; GPX6; PRKACG; DUOX2; GSR
Thyroid hormone signaling pathway
PIK3CA; PIK3R3; PLCB4; SLC9A1; DIO1; TRP53; SRC; ATP1A4; MAP2K1; BMP4
Oxytocin signaling pathway
CCND1; PLCB3; MAP2K1; PPP1R12B; PLA2G4A; CAMK2D; HRAS; ACTG1; GUCY1A3; CAMKK2
Aldosterone synthesis and secretion
GNAS; CALML5; ADCY6; MC2R; ADCY8; PLCB3; PRKCG; PRKD2; HSD3B5; DDX1
Aldosterone-regulated sodium reabsorption
INSR; INS; HSD11B2; INS2; KCNJ1; KRAS; SCNN1B; INS1; NEDD4L; MAPK3
Endocrine and other factor-regulated calcium reabsorption
ATP1A2; FXYD2; ATP1B2; PRKCA; PLCB1; KLK1B8; PRKCB; BDKRB2; KLK1B3; ATP1A1
Salivary secretion
GUCY1B3; FXYD2; ATP1B4; ATP1B2; ATP2B4; VAMP2; PRKACB; CALM3; PLCB1; PRKCG
Gastric acid secretion
KCNJ10; ITPR3; ATP4A; KCNJ16; KCNE2; CALM1; PLCB2; SLC26A7; PLCB3; CA2
Pancreatic secretion
CLCA1; RAP1B; SLC26A3; CLCA2; PRSS3; CLCA3; GNAQ; CCKAR; CPB2; TPCN2
Amphetamine addiction
PRKCA; SLC18A1; NETO2; ATF4; PRKACG; CAMK2G; CALM1; FOS; SLC14A2; CREB3L2
Morphine addiction
PDE8A; GABRB2; GABRD; LOC100328615; GNAI3; OPRM1; ARRB1; GABRE; GABRA6; PDE1B
Vibrio cholerae infection
PRKACB; PLCG1; ATP6V0D2; ATP6V1E1; ATP6V0D1; ATP6V0E1; ATP6V1C2; ATP6V1H; ACTG1; MUC2
Pathogenic Escherichia coli infection
TUBA4A; WAS; FYN; OCLN; TUBB1; TUBA3D; NCK2; TUBAL3; TUBB6; TLR5
African trypanosomiasis
PLCB2; HBA2; ICAM1; FAS; IL1B; PRKCA; HBB-B2; HBA1; Fasl; GNAQ
Amoebiasis
LAMC1; PIK3CG; ACTN2; SERPINB9; COL4A1; CXCL8; LAMA1; RAB5C; SERPINB1C; GNAQ
Hepatitis B
NFKB1; CXCL8; PIK3CA; IFNA2; PIK3CD; IFNA12; PCNA; HSPG2; Casp3; MAP3K1
Influenza A
OAS1B; BLB2; IKBKE; HLA-DOA; IFNB; NXT2; DDX58; IFNB1; HLA-DMB; TNFRSF10B
Pathways in cancer
TRAF4; TFG; FGF7; GNGT1; FGF1; WNT8B; PTGER2; GNG11; LAMC2; Ar
Proteoglycans in cancer
IGF2; VEGFA; CAMK2A; PRKACB; FASLG; CD63; Casp3; RAF1; TRP53; PLCG1
MicroRNAs in cancer
CCNG1; ZFPM2; NOTCH3; HOXD10; APC; ZEB1; TRP63; DNMT3B; RAF1; MMP16
Glioma
NRAS; SHC4; CALM1; PIK3R1; SHC3; CCND1; Pdgfa&Pdgfb; HRAS; PRKCA; CALML3
Non-small cell lung cancer
PRKCG; RB1; AKT1; NRAS; ARAF; TP53; HRAS; PIK3CA; PRKCA; ERBB2
Choline metabolism in cancer
DGKZ; DGKE; SLC22A3; DGKA; WASF2; TSC1; PIK3CA; PIK3R3; PLD2; PPAP2C

Protein Function

Prkca has several biochemical functions, for example, ATP binding, calcium-dependent protein kinase C activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkca itself. We selected most functions Prkca had, and list some proteins which have the same functions with Prkca. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DHX33; DDX41; MAT2A; CDK12; MYHC4; DCLK1A; MYHZ1.1; CLPXA; GLUD1; CKBB
Function calcium-dependent protein kinase C activity
Related Protein PRKCA; ALPK2; CCL3; PRKCG
Function enzyme binding
Related Protein CNTNAP2; LAMP2; ESR2; C2orf56; UBE2L3; SLC18A1; CAT; GRIN1; PLAUR; CYP2C8
Function histone kinase activity (H3-T6 specific)
Related Protein PRKCBB; PRKCB; PRKCA
Function protein binding
Related Protein CHCHD6; TCF12; SIRT7; MRPS31; GPN3; NMNAT1; MLLT10; HSF2; CHMP2B; PEX2
Function protein kinase C activity
Related Protein PRKCQ; PRKCBB; PKN2; PRKD2; PKN3; PRKCZ; PRKCA; PRKCE; PRKCG; PKN1
Function protein kinase activity
Related Protein CDKL2; PTK2AA; CSNK1G3; PAK2; GRK1A; STK35L; BSK146; SCYL2; NLK; GUCY2E
Function protein serine/threonine kinase activity
Related Protein TAOK1; ACVR1L; DCLK3; PIM3; BMP2K; CDC42BPB; WNK2; CSNK1E; NEK6; RPS6KB2
Function zinc ion binding
Related Protein RNF144A; WBP2NL; COP1; WHSC1; ZNF34; TRIM8; SF1; SQSTM1; HE2; ANPEPA

Interacting Protein

Prkca has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkca here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkca.
EGFR; Sdc4; bzlf1_ebvb9; NCF1; numb; SDC4; ndb25_parsc; inaD; Jak2; GIPC1; EIF2S1; HSP90AB1; UBC; BRAF