prpf18
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  • Official Full Name
  • PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
  • Background
  • Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18.
  • Synonyms
  • PRPF18; PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae); PRP18 pre mRNA processing factor 18 homolog (yeast); pre-mRNA-splicing factor 18; hPrp18; FLJ10210; Pre mRNA splicing factor 18; PRP18; PRP18 homolog; PRP18 pre mRNA processing factor 18 homolog (PRPF18); PRP18 pre mRNA processing factor 18 homolog (S. cerevisiae); PRP18_HUMAN; PRP18 pre-mRNA processing factor 18 homolog(PRPF18)
Cat.#:PRPF18-4717RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRPF18 Protein
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Cat.#:PRPF18-3622RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRPF18 Protein, His-tagged
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Cat.#:PRPF18-421ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRPF18
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Cat.#:PRPF18-2829HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRPF18 293 Cell Lysate
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Involved Pathway

PRPF18 involved in several pathways and played different roles in them. We selected most pathways PRPF18 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF18 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
SRSF2; SRSF4; HNRNPA1; XAB2; SRSF5B; SRSF6; SRSF7; HSC70; HSPA6; CHERP

Protein Function

PRPF18 has several biochemical functions, for example, contributes_to second spliceosomal transesterification activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF18 itself. We selected most functions PRPF18 had, and list some proteins which have the same functions with PRPF18. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to second spliceosomal transesterification activity
Related Protein PRPF18; CDC40

Interacting Protein

PRPF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF18.
sdhA; Nek2; YWHAZ; Ddb1

PRPF18 Related Articles

Zubovic, L; Baralle, M; et al. Mutually exclusive splicing regulates the Na-v 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands. NUCLEIC ACIDS RESEARCH 40:6255-6269(2012).
Ezeokonkwo, C; Ghazy, MA; et al. Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae. FEBS LETTERS 586:1173-1178(2012).