prps1
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  • Official Full Name
  • phosphoribosyl pyrophosphate synthetase 1
  • Background
  • This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PRPS1; phosphoribosyl pyrophosphate synthetase 1; deafness, X linked 2, perceptive, congenital , DFN2; ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS I; ribose phosphate diphosphokinase 1; deafness 2, perceptive, congenital; ribose-phosphate diph
Cat.#:PRPS1-30999THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRPS1
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Cat.#:PRPS1-494HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRPS1, His-tagged
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Cat.#:PRPS1-13460MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRPS1 Protein
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Cat.#:PRPS1-4723RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRPS1 Protein
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Cat.#:PRPS1-814CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PRPS1 Protein, His-tagged
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Cat.#:PRPS1-3626RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRPS1 Protein, His-tagged
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Cat.#:PRPS1-2820HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRPS1 293 Cell Lysate
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Involved Pathway

PRPS1 involved in several pathways and played different roles in them. We selected most pathways PRPS1 participated on our site, such as Pentose phosphate pathway, Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose phosphate pathway
ALDOB; PFKP; GPI; PGD; TKTL1; FBP1A; RBKS; PGLS; GPIB; FBP1B
Purine metabolism
XDH; POLR3K; NME3; NT5C2; HPRT1; PDE5AB; PDE2A; ENTPD3; POLD1; PDE4A
Metabolic pathways
PNLIPRP2; ATP6V1A; LIPT2; ALG2; ALOX12B; ybaS; PDXKA; COX6C; PDHX; PAPSS1
Carbon metabolism
PKLR; ACO2; PKMA; DLST; OGDHL; ALDOAB; TPI1A; DLAT; PCXB; PRPS1A
Biosynthesis of amino acids
TKTL2; TKT; TALDO1; PGAM1B; ACO2; PRPS2; GLULB; MAT1A; PYCR2; BCAT2

Protein Function

PRPS1 has several biochemical functions, for example, ADP binding, AMP binding, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPS1 itself. We selected most functions PRPS1 had, and list some proteins which have the same functions with PRPS1. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein ERN1; ADCK3; ME1; PRKAG1; GLUD1; MYO18A; PRKAG2; ACTA1; MYH10; APAF1
Function AMP binding
Related Protein APRT; ACSS2; CYB5R3; PRKAG1; FBP1; PYGM; ACSS1; PRPS1; PRKAG2; PRPS2
Function ATP binding
Related Protein UBE2T; GMPS; FER; GC3; CDK9; MKKS; MAPK8B; ENTPD2; PTK2BB; CMPK1
Function GDP binding
Related Protein RAB31; RAB28; ARL2; RAB10; PRPS2; KRAS; SRP54A; RAP2B; RAB21; RAB8B
Function carbohydrate binding
Related Protein FREM1; CLEC14A; SIGLEC12; FCNA; NOMO3; LMAN2; SIGLEC14; MAG; CLEC4A2; LGALSLA
Function kinase activity
Related Protein NME2A; SGK2A; NR5A1B; GRK1B; DCLK1A; PRKCHB; MTOR; CAMK2A; PRKAR1AA; MAP3K12
Function magnesium ion binding
Related Protein ATP10A; GSS; SRR; NLK; TSSK1; NT5C3B; PRPS1A; TSSK4; MAP3K8; COMTA
Function protein binding
Related Protein TERF1; KLC3; CCDC135; ELAVL2; PTK7; CREM; RPS18; PAK1IP1; SH2D2A; TLR3
Function protein homodimerization activity
Related Protein BST2; ACAT1; LSM1; GCH1; NPPC; MLL1; EIF2AK3; CREB3; ZBTB16; GRIK2
Function ribose phosphate diphosphokinase activity
Related Protein PRPS1; PRPS1L1; PRPS1B; PRPS2; PRPS1A; PRPSAP1

Interacting Protein

PRPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPS1.
PRPS2; PRPSAP1; SPG21; GORASP2; PRPSAP2; PRPSAP1; FBXO31

PRPS1 Related Articles

Al-Maawali, A; Dupuis, L; et al. Prenatal growth restriction, retinal dystrophy, diabetes insipidus and white matter disease: expanding the spectrum of PRPS1-related disorders. EUROPEAN JOURNAL OF HUMAN GENETICS 23:310-316(2015).
Fridman, A; Saha, A; et al. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. BIOCHEMICAL JOURNAL 454:91-99(2013).