PRSS21 Protein, protease, serine, 21 (testisin)


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Official Full Name protease, serine, 21 (testisin)
Background This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. It is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and it may be involved in progression of testicular tumors of germ cell origin. Alternative splicing of this gene results in three transcript variants encoding three different isoforms.
Synonyms PRSS21; protease, serine, 21 (testisin); testisin; ESP 1; TEST1; Eosinophil serine protease 1; ESP1; Serine protease 21; serine protease from eosinophils; ESP-1
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRSS21-2245H Recombinant Human PRSS21 Protein (42-288 aa), His-tagged E.coli His
    Human PRSS21-2804HCL Recombinant Human PRSS21 293 Cell Lysate HEK293 N/A
    Human PRSS21-2805HCL Recombinant Human PRSS21 293 Cell Lysate HEK293 N/A

    PRSS21 involved in several pathways and played different roles in them. We selected most pathways PRSS21 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRSS21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PRSS21 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRSS21 itself. We selected most functions PRSS21 had, and list some proteins which have the same functions with PRSS21. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PFDN2; TBRG4; ARF4; TMEM79; TAL2; ABCD3; TNFRSF10A; ASAP1; NAT8; C1QTNF9
    serine-type endopeptidase activity MCPT1; Acr; F10; TPSB2; HTRA1; F11; GZME; HGFA; TMPRSS11E; KLK1B1
    serine-type peptidase activity PRSS8; KLK10; TMPRSS13B; HTRA2; TMPRSS12; KLK11; ST14; KLK1B11; Reln; ZFYVE9

    PRSS21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRSS21 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRSS21.


    Robinson, KS; Watt, SA; et al. RNAi depletion of PRSS21 in cutaneous squamous cell carcinoma keratinocytes induces maspin dependent apoptosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 133:S72-S72(2013).
    Zhou, C; Kang, WJ; et al. Functional Characterization of Double-knockout Mouse Sperm Lacking SPAM1 and ACR or SPAM1 and PRSS21 in Fertilization. JOURNAL OF REPRODUCTION AND DEVELOPMENT 58:330-337(2012).

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