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Official Full Name proteasome (prosome, macropain) 26S subunit, ATPase, 4
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
Synonyms PSMC4; proteasome (prosome, macropain) 26S subunit, ATPase, 4; MIP224; 26S protease regulatory subunit 6B; MB67 interacting protein; MGC8570; MGC13687; MGC23214; protease 26S subunit 6; S6; Tat binding protein 7; TBP 7; TBP7; TBP-7; Tat-binding protein 7
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PSMC4-2760HCL Recombinant Human PSMC4 293 Cell Lysate HEK293 N/A
    Human PSMC4-2761HCL Recombinant Human PSMC4 293 Cell Lysate HEK293 N/A
    Human PSMC4-29835TH Recombinant Human PSMC4, His-tagged E.coli His
    Human PSMC4-417H Recombinant Human PSMC4 Protein, His-tagged E.coli His
    Mouse PSMC4-13584M Recombinant Mouse PSMC4 Protein Mammalian Cell His
    Rat PSMC4-4782R Recombinant Rat PSMC4 Protein Mammalian Cell His
    Cynomolgus Monkey PSMC4-821C Recombinant Cynomolgus PSMC4 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PSMC4-3665R Recombinant Rhesus monkey PSMC4 Protein, His-tagged Mammalian Cell His
    Zebrafish PSMC4-10140Z Recombinant Zebrafish PSMC4 Mammalian Cell His

    PSMC4 involved in several pathways and played different roles in them. We selected most pathways PSMC4 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome PSMC5; PSMB7; PSMB10; PSMD2; SHFM1; PSMD13; PSMF1; PSMC1; PSMA1; POMP
    Epstein-Barr virus infection MAP3K7; HLA-B; PIK3CA; ITGAL; RBPJL; CD40; CD44; PSMC1; POLR2A; PSMD7

    PSMC4 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC4 itself. We selected most functions PSMC4 had, and list some proteins which have the same functions with PSMC4. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity ASNA1; DNAH5; KIF22; KIF23; ATAD1; DNAH11; VCP; KIF14; ABCF2A; DDX3X
    TBP-class protein binding BRF1B; BRF1A; PSMC1A; HHEX; PSMC4; TAF1B; EFCAB11; TAF1; DR1; TAF1L
    proteasome-activating ATPase activity PSMC1B; PSMC3; PSMC4; PSMC2; PSMC1; PSMC5; PSMC1A; PSMC6
    protein binding FGFR3; FAM58A; DUSP15; NUMA1; RBMX2; RSPO1; FBXO25; ZBTB2; TTC19; EPAS1

    PSMC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC4.

    PSMD10; PSMC5

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