psmc4
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  • Official Full Name
  • proteasome (prosome, macropain) 26S subunit, ATPase, 4
  • Background
  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
  • Synonyms
  • PSMC4; proteasome (prosome, macropain) 26S subunit, ATPase, 4; MIP224; 26S protease regulatory subunit 6B; MB67 interacting protein; MGC8570; MGC13687; MGC23214; protease 26S subunit 6; S6; Tat binding protein 7; TBP 7; TBP7; TBP-7; Tat-binding protein 7
Cat.#:PSMC4-417HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC4 Protein, His-tagged
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Cat.#:PSMC4-29835THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC4, His-tagged
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Cat.#:PSMC4-13584MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PSMC4 Protein
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Cat.#:PSMC4-4782RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PSMC4 Protein
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Cat.#:PSMC4-821CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PSMC4 Protein, His-tagged
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Cat.#:PSMC4-3665RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PSMC4 Protein, His-tagged
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Cat.#:PSMC4-10140ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSMC4
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Cat.#:PSMC4-2760HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMC4 293 Cell Lysate
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Cat.#:PSMC4-2761HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMC4 293 Cell Lysate
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Involved Pathway

PSMC4 involved in several pathways and played different roles in them. We selected most pathways PSMC4 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteasome
PSMB10; IFNG1-2; PSMD8; POMP; IFNG; PSMC2; PSMB3; PSME1; PSMB1; PSMA2
Epstein-Barr virus infection
ITGAL; PSMC4; MAP2K7; GSK3B; PSMD4; POLR2I; HLA-DRB3; HSPA8; YWHAH; EIF2AK4

Protein Function

PSMC4 has several biochemical functions, for example, ATP binding, ATPase activity, TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC4 itself. We selected most functions PSMC4 had, and list some proteins which have the same functions with PSMC4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX24; DNAJA2L; P2RX8; ATAD2; KCNJ1; MAP4K1; IRAK4; TARS; AK2; UBE2Q1
Function ATPase activity
Related Protein ABCA4; KIF2C; ABCF1; MACF1; KIF20A; HSPA1B; ABCE1; PICK1; ABCD3A; INO80
Function TBP-class protein binding
Related Protein PSMC1; CAND2; PSMC6; BRF1; EFCAB11; TAF1L; HHEX; DR1; PSMC4; TAF1
Function proteasome-activating ATPase activity
Related Protein PSMC4; PSMC6; PSMC3; PSMC1A; PSMC1B; PSMC2; PSMC1; PSMC5
Function protein binding
Related Protein FABP3; GNB2L1; TES; C10orf33; FCRL2; SGK1; PTK2; SYT2; BBC3; NCK2

Interacting Protein

PSMC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC4.
PSMD10; PSMC5