ptp4a3
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  • Official Full Name
  • protein tyrosine phosphatase type IVA, member 3
  • Background
  • This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Synonyms
  • PTP4A3; protein tyrosine phosphatase type IVA, member 3; PRL3; PRL-3; PRL-R; protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase of regenerating liver 3;
Cat.#:PTP4A3-1093HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Tyrosine Phosphatase Type IVA, Member 3
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Cat.#:PTP4A3-379HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTP4A3, His-tagged
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Cat.#:PTP4A3-676HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTP4A3, GST-tagged
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Cat.#:PTP4A3-677HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTP4A3, 2-173 aa, His-tagged
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Cat.#:PTP4A3-1035HTag:Met/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTP4A3 Protein, Met & His-tagged
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Cat.#:PTP4A3-2053HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTP4A3, His-tagged
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Cat.#:PTP4A3-5468HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTP4A3 protein, His-tagged
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Cat.#:PTP4A3-13667MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTP4A3 Protein
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Cat.#:PTP4A3-3699RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTP4A3 Protein, His-tagged
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Cat.#:PTP4A3-12393ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PTP4A3
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Cat.#:PTP4A3-2692HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTP4A3 293 Cell Lysate
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Cat.#:PTP4A3-2693HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTP4A3 293 Cell Lysate
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Involved Pathway

PTP4A3 involved in several pathways and played different roles in them. We selected most pathways PTP4A3 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTP4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events mediated by PRL
PTP4A2; PTP4A1; PTP4A3; RABGGTA; ATF5; RABGGTB; LRP8

Protein Function

PTP4A3 has several biochemical functions, for example, prenylated protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTP4A3 itself. We selected most functions PTP4A3 had, and list some proteins which have the same functions with PTP4A3. You can find most of the proteins on our site.
Function
Related Protein
Function prenylated protein tyrosine phosphatase activity
Related Protein PTP4A2; PTP4A3
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein CDKN3; SACM1LA; DUSP2; CDC14B; NT5DC3; DUSP3B; PTP4A1; DUSP9; DUSP13A; MTMR2

Interacting Protein

PTP4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTP4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTP4A3.
Tcr-alpha; q65zq1_human; MYO1C; TNPO2; TIMM23; SURF4; TTI1; PSMD3; ZW10; MYO1B; OPA1; DPM1; USO1

PTP4A3 Related Articles

Sharlow, ER; Wipf, P; et al. Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:661-673(2014).
Guzinska-Ustymowicz, K; Kisluk, J; et al. Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases. ADVANCES IN MEDICAL SCIENCES 58:221-226(2013).