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Official Full Name protein tyrosine phosphatase type IVA, member 3
Background This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Synonyms PTP4A3; protein tyrosine phosphatase type IVA, member 3; PRL3; PRL-3; PRL-R; protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase of regenerating liver 3;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Met
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PTP4A3-3657H Recombinant Human PTP4A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ptp4a3-5232M Recombinant Mouse Ptp4a3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PTP4A3-1035H Recombinant Human PTP4A3 Protein, Met & His-tagged E.coli Met/His
    Human PTP4A3-1093H Recombinant Human Protein Tyrosine Phosphatase Type IVA, Member 3 E.coli N/A
    Human PTP4A3-2053H Recombinant Human PTP4A3, His-tagged E.coli His
    Human PTP4A3-2692HCL Recombinant Human PTP4A3 293 Cell Lysate HEK293 N/A
    Human PTP4A3-2693HCL Recombinant Human PTP4A3 293 Cell Lysate HEK293 N/A
    Human PTP4A3-379H Recombinant Human PTP4A3, His-tagged E.coli His
    Human PTP4A3-5468H Recombinant Human PTP4A3 protein, His-tagged E.coli His
    Human PTP4A3-676H Recombinant Human PTP4A3, GST-tagged E.coli GST
    Human PTP4A3-677H Recombinant Human PTP4A3, 2-173 aa, His-tagged E.coli His
    Mouse PTP4A3-13667M Recombinant Mouse PTP4A3 Protein Mammalian Cell His
    Rhesus Macaque PTP4A3-3699R Recombinant Rhesus monkey PTP4A3 Protein, His-tagged Mammalian Cell His
    Zebrafish PTP4A3-12393Z Recombinant Zebrafish PTP4A3 Mammalian Cell His

    PTP4A3 involved in several pathways and played different roles in them. We selected most pathways PTP4A3 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTP4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by PRL PTP4A3; PTP4A1; ATF5; RABGGTB; LRP8; RABGGTA; PTP4A2

    PTP4A3 has several biochemical functions, for example, prenylated protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTP4A3 itself. We selected most functions PTP4A3 had, and list some proteins which have the same functions with PTP4A3. You can find most of the proteins on our site.

    Function Related Protein
    prenylated protein tyrosine phosphatase activity PTP4A3; PTP4A2
    protein tyrosine/serine/threonine phosphatase activity CDC14C; SACM1LB; PTP4A2B; DUSP3B; DUSP13; PTP4A2A; CDKN3; PTPMT1; PXYLP1; SSH3

    PTP4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTP4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTP4A3.

    Tcr-alpha; q65zq1_human; MYO1C; TNPO2; TIMM23; SURF4; TTI1; PSMD3; ZW10; MYO1B; OPA1; DPM1; USO1

    Sharlow, ER; Wipf, P; et al. Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:661-673(2014).
    Guzinska-Ustymowicz, K; Kisluk, J; et al. Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases. ADVANCES IN MEDICAL SCIENCES 58:221-226(2013).

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