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Official Full Name poly (ADP-ribose) polymerase 2
Background This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
Synonyms PARP2; poly (ADP-ribose) polymerase 2; ADP ribosyltransferase (NAD+; poly(ADP ribose) polymerase) like 2 , ADPRTL2, poly (ADP ribose) polymerase family, member 2; poly [ADP-ribose] polymerase 2; ADP ribosyltransferase like 2; ADPRT 2; ADPRT-2; ADPRT2; ADPRTL 2; ADPRTL 3; ADPRTL2; ADPRTL3; hPARP 2; hPARP-2; hPARP2; NAD(+) ADP ribosyltransferase 2; NAD(+) ADP-ribosyltransferase 2; pADPRT 2; pADPRT-2; pADPRT2; PARP 2; PARP-2; PARP2_HUMAN; Poly (ADP ribose) polymerase family member 2; Poly (ADP ribosyl) transferase like 2; Poly [ADP ribose] synthetase 2; Poly(ADP ribose) synthetase; Poly[ADP-ribose] synthase 2; OTTHUMP00000231900; OTTHUMP00000231902; OTTHUMP00000231904; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthetase 2; poly (ADP-ribosyl) transferase-like 2; poly (ADP-ribose) polymerase family, member 2; ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PARP2-157H Recombinant Human PARP2 Protein, GST-tagged Insect Cell GST
    Human PARP2-433H Recombinant Human Poly (ADP-ribose) Polymerase 2, GST-tagged Sf9 Insect Cell GST
    Human PARP2-7559H Recombinant Human PARP2, His-tagged E.coli His
    Mouse PARP2-12373M Recombinant Mouse PARP2 Protein Mammalian Cell His
    Mouse Parp2-453M Recombinant Mouse Parp2, His-tagged Sf21 Insect Cell His
    Mouse Parp2-613M Recombinant Mouse Poly (ADP-ribose) Polymerase Family, Member 2 Sf9 Insect Cell N/A
    Mouse Parp2-641M Recombinant Mouse Parp2, His-tagged Sf21 Insect Cell His
    Rhesus Macaque PARP2-3308R Recombinant Rhesus monkey PARP2 Protein, His-tagged Mammalian Cell His
    Zebrafish PARP2-8014Z Recombinant Zebrafish PARP2 Mammalian Cell His
    Kit-1799 PARP2 Chemiluminescent Assay Kit N/A
    Kit-1800 PARP2 Colorimetric Assay Kit N/A
    Kit-1801 PARP2 Homogeneous Assay Kit N/A

    Parp2 involved in several pathways and played different roles in them. We selected most pathways Parp2 participated on our site, such as Base Excision Repair, DNA Damage Recognition in GG-NER, DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with Parp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Base Excision Repair NEIL3; PARP4; xthA; HMGB1; UNGA; NEIL2; APEX2; HMGB1B; APEX1; NEIL1
    DNA Damage Recognition in GG-NER COPS7B; INO80C; DDB2; MCRS1; DDB1; ACTL6A; ACTR5; INO80; COPS3; COPS4
    DNA Double-Strand Break Repair RAD9; TOPBP1; CLSPN; HUS1; SMARCA5; EYA3; BRCC3; TIPIN; PPP4R2; EME1
    Dual Incision in GG-NER DDB2; DDB1; CHD1L; PARP2
    Formation of Incision Complex in GG-NER CHD1L; DDB2; DDB1; CETN2; PARP2; USP45; PIAS3; RNF111
    Global Genome Nucleotide Excision Repair (GG-NER) DDB2; PIAS3; CHD1L; COPS6; YY1A; ACTL6A; INO80C; GPS1; INO80E; COPS2

    Parp2 has several biochemical functions, for example, DNA binding, NAD+ ADP-ribosyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Parp2 itself. We selected most functions Parp2 had, and list some proteins which have the same functions with Parp2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TADA2A; RNF11; RPP21; HER8.2; APP; HER6; DMTF1; FOXB1B; DEDD2; HOXD13
    NAD+ ADP-ribosyltransferase activity PARP12A; PARP2; GIG2P; GIG2L; PARP16; GIG2J; PARP11; PARP3; TNKS; SIRT4
    protein binding MLLT3; MORN4; RBM44; ZNF747; AIG1; NOMO2; FAH; CAV1; ABCA1; PRR3

    Parp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Parp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Parp2.

    FKBP3; STAC; FAM168B; VPS37C; nad+; mgc:39545; NDUFA4; SYNJ2; DFFB; MYO1D; RTN3; IFNA16; PCCA; HMGN2; HIST1H1E; CD58; PTMS

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