Recombinant Human PARP2 Protein, GST-tagged

• Cat.No.: PARP2-006H
• Product Overview: Active recombinant full length human PARP2 protein (2-583) with a N-terminal GST tag was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 2-583
• Description: This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
• Molecular Mass: 95.5 kDa
• Purity: ≥50% estimated by SDS-PAGE
• Unit Definition: One unit of PARP incorporates 100 pmol of poly(ADP) in 1 minute from NAD into the acid-insoluble form.
• Stability: ≥ 2 years
• Storage: At -80 centigrade.
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 16 mM glutathione, 20% glycerol, and 3 mM DTT

Gene Information

• Gene Name: PARP2 poly(ADP-ribose) polymerase 2 [ Homo sapiens (human) ]
• Official Symbol: PARP2
• Synonyms: PARP2; poly(ADP-ribose) polymerase 2; ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2; poly [ADP-ribose] polymerase 2; ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase diphtheria toxin-like 2; ADPRT-2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; hPARP-2; poly (ADP-ribose) polymerase family, member 2; poly (ADP-ribosyl) transferase-like 2; poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2; protein poly-ADP-ribosyltransferase PARP2; EC 2.4.2.30
• Gene ID: 10038
• mRNA Refseq: NM_005484
• Protein Refseq: NP_005475
• MIM: 607725
• UniProt ID: Q9UGN5