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Official Full Name PDE10A phosphodiesterase 10A
Background The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal;transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP;and cGMP to the corresponding nucleoside 5 monophosphate, but has higher affinity for cAMP, and is more efficient;with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Synonyms PDE10A; phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; FLJ11894; FLJ25677
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-2043 PDE10A Assay Kit N/A
    Mouse Pde10a-4739M Recombinant Mouse Pde10a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PDE10A-1610H Recombinant Human PDE10A, GST-tagged Sf9 Insect Cell GST
    Human PDE10A-304H Recombinant Human PDE10A Protein, His-tagged E.coli His
    Human PDE10A-3355HCL Recombinant Human PDE10A 293 Cell Lysate HEK293 N/A
    Human PDE10A-440H Recombinant Human Phosphodiesterase 10A, GST-tagged Sf9 Insect Cell GST
    Mouse PDE10A-12544M Recombinant Mouse PDE10A Protein Mammalian Cell His
    Mouse Pde10a-438M Recombinant Mouse Phosphodiesterase 10A, GST-tagged Sf9 Insect Cell GST
    Rat PDE10A-4324R Recombinant Rat PDE10A Protein Mammalian Cell His
    Rat Pde10a-439R Recombinant Rat Phosphodiesterase 10A, GST-tagged Sf9 Insect Cell GST
    Zebrafish PDE10A-11324Z Recombinant Zebrafish PDE10A Mammalian Cell His

    Pde10a involved in several pathways and played different roles in them. We selected most pathways Pde10a participated on our site, such as G alpha (s) signalling events, GPCR downstream signaling, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pde10a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G alpha (s) signalling events POMCB; DRD5; PTH2; ADORA2A; ADORA2B; RLN2; RAMP2; PTHRP2; RXFP2B; ADM
    GPCR downstream signaling CCR8; OXGR1A.2; PDE10A; ADORA1; CCK; GPR18; DRD4; NMB; TAC2; DRD2
    Hemostasis RAPGEF3; CFHL4; GATA2; C6orf25; BRPF3; CLEC1B; AKAP10; PROCR; FN1B; GATA1A
    Morphine addiction GNG12; PDE7A; PRKCA; GRK6; GNB2; GNG4; PDE4C; PDE1C; GABBR2; PDE4D
    Nitric oxide stimulates guanylate cyclase KCNMB1; KCNMB2; KCNMA1; PDE10A
    Platelet homeostasis KCNMB2; PDE10A; KCNMB1; APOER2; SLC8A2A; ATP2B1B; ATP2B3A; KCNMA1
    Purine metabolism PNP5A; NME2B.1; ADKB; Adcy4; POLR1C; POLR1E; POLR2C; ADK; AK2; CANT1A
    Signal Transduction SOX9A; PYGO1; CSHL1; METAP1; OXGR1; RAMP1; CXCL11.8; PROKR2; CALML4; RHOT1A

    Pde10a has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pde10a itself. We selected most functions Pde10a had, and list some proteins which have the same functions with Pde10a. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-GMP phosphodiesterase activity PDE6G; PDE11A; PDE6B; PDE9A; PDE6H; PDE5A; PDE6C; PDE10A; PDE6A
    3,5-cyclic-nucleotide phosphodiesterase activity PDE8A; PDE4D; PDE3B; PDE8B; PDE9A; PDE11A; PDE6D; PDE5A; PDE10A; PDE5AB
    cGMP binding PDE6G; PRKG2; PDE11A; PDE10A; CNGA1; PRKG1A; CNGA5; PDE6C; PRKG1; CNGA4
    cGMP-stimulated cyclic-nucleotide phosphodiesterase activity PDE2A; PDE11A; USB1; TDP2B; PDE10A
    drug binding SETD6; FSCN1; DCK; ADH1; CHRNB2; NR1I2; CHRM1; CYP2C9; DRD4; CHRM3
    metal ion binding ZSCAN4D; GM5077; FHL3B; TATDN3; LHX8; ZDHHC15B; CYP2C38; OAS2; CPXCR1; RAG1

    Pde10a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pde10a here. Most of them are supplied by our site. Hope this information will be useful for your research of Pde10a.


    Guez-Barber, D; Fanous, S; et al. FACS purification of immunolabeled cell types from adult rat brain. JOURNAL OF NEUROSCIENCE METHODS 203:10-18(2012).
    Charych, EI; Jiang, LX; et al. Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia. JOURNAL OF NEUROSCIENCE 30:9027-9037(2010).

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