protein a
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  • Official Full Name
  • Background
  • Protein A is a 56 kDa MSCRAMM surface protein originally found in the cell wall of the bacterium Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It is composed of five homologous Ig-binding domains that fold into a three-helix bundle. Each domain is able to bind proteins from many of mammalian species, most notably IgGs. It binds the heavy chain with the Fc region of most immunoglobulins and also within the Fab region in the case of the human VH3 family. Through these interactions in serum, where IgG molecules are bound in the wrong orientation (in relation to normal antibody function), the bacteria disrupts opsonization and phagocytosis.
  • Synonyms
  • Immunoglobulin G binding protein A protein; SPA protein; Staphylococcal protein A protein; SpA; 56 kDa MSCRAMM; ProteinA; PROTEIN A; Staphylococcal protein A; IgG binding protein A; SAOUHSC_00069; Immunoglobulin G binding protein A; gG-binding protein A
Cat.#:COP09Tag:His
Source (Host):E. coliSpecies:Bacterial
Product nameRecombinant Protein A, His-tagged
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Cat.#:Protein A-524Tag:
Source (Host):Species:Staphylococcal
Product nameRecombinant Staphylococcal Protein A Protein
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Cat.#:ProteinA-1390STag:N/A
Source (Host):E. coliSpecies:Staphylococcal
Product nameRecombinant Staphylococcal Putative IgG-binding Protein
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Cat.#:Protein A-253STag:
Source (Host):E.coliSpecies:Staphylococcus
Product nameRecombinant Staphylococcus protein A
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Cat.#:COP32Tag:N/A
Source (Host):E. coliSpecies:Staphylococcal
Product nameRecombinant Staphylococcal Protein A
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Cat.#:Protein A-3149STag:His
Source (Host):E. coliSpecies:Staphylococcus aureus
Product nameRecombinant Staphylococcus aureus Protein A protein, His-tagged
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Cat.#:Protein A-8149STag:Biotin/His
Source (Host):E. coliSpecies:Staphylococcus aureus
Product nameRecombinant Staphylococcus aureus Protein A protein, Biotin/His-tagged
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Cat.#:COP26Tag:
Source (Host):Species:
Product nameProtein A Agarose High Flow Resin
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Cat.#:Protein A-001MTag:
Source (Host):Species:
Product nameRecombinant Protein A methacrylic resin
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Cat.#:Protein A-28ATag:
Source (Host):Species:
Product nameProtein A Beads
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Cat.#:Protein A-33ATag:
Source (Host):Species:
Product nameTargetLock Protein A Beads
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Cat.#:Protein A-7PTag:
Source (Host):Species:
Product namesuperProteinA polymer resin
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Cat.#:Protein A-9ATag:
Source (Host):Species:
Product nameAlkali-tolerant Protein A agarose fast flow
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Cat.#:COP27Tag:
Source (Host):Species:
Product nameSuper Protein A Agarose High Flow Resin
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Protein A Related Articles

Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).
Yang, YR; Feng, JD; et al. Immune Responses to a Recombinant Rv0057-Rv1352 Fusion Protein of Mycobacterium tuberculosis. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:39-48(2015).