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RASSF5

  • Official Full Name

    Ras association (RalGDS/AF-6) domain family member 5

  • Overview

    This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    RASSF5; Ras association (RalGDS/AF-6) domain family member 5; RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3; MGC10823; MGC17344; Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; OTTHUMP00000034534; OTTHUMP00000034535; Rap1-binding protein; Ras association (RalGDS/AF-6) domain family 5; Ras effector-like protein; novel Ras effector 1; tumor suppressor RASSF3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RASSF5-5443H Recombinant Human RASSF5, MYC/DDK-tagged HEK293 Myc/DDK
Human RASSF5-29726TH Recombinant Human RASSF5 E.coli N/A
Human RASSF5-1071H Recombinant Human RASSF5, GST-tagged E.coli GST
Human RASSF5-29658TH Recombinant Human RASSF5, His-tagged E.coli His
Human RASSF5-2495HCL Recombinant Human RASSF5 293 Cell Lysate HEK293 N/A
Human RASSF5-4638H Recombinant Human RASSF5 protein, GST-tagged E.coli GST 1-265aa
Mouse RASSF5-13967M Recombinant Mouse RASSF5 Protein Mammalian Cell His
Mouse RASSF5-7449M Recombinant Mouse RASSF5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RASSF5-7449M-B Recombinant Mouse RASSF5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rassf5-5397M Recombinant Mouse Rassf5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken RASSF5-1830C Recombinant Chicken RASSF5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RASSF5 Related Articles
  • RASSF5 Related Signal Pathway

RASSF5 involved in several pathways and played different roles in them. We selected most pathways RASSF5 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFGFR4;MAPK1;FOXO4;Kitl;PIK3R1;GRB2;PLD2;PLA2G2D;PIK3CD
Rap signaling pathwayRAP1B;FGFR1;BRAF;FGF7;AKT2;KITLG;INSR;Fgf15;GNAI3
Leukocyte transendothelial migrationCLDN3;PRKCA;GNAI2;THY1;PIK3R5;CLDN20;MYL9;NCF1;PECAM1
Pathways in cancerGNG13;RXRB;RUNX1;AGTR1A;FZD1;LPAR2;FZD5;SMAD3;LAMA5
Non-small cell lung cancerMAP2K2;PIK3R2;PRKCG;PIK3R5;TGFA;PLCG2;EML4;CASP9;RARB

RASSF5 has several biochemical functions, for example, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF5 itself. We selected most functions RASSF5 had, and list some proteins which have the same functions with RASSF5. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZNF274;B3GNT1;RNFT1;RNF11A;ZNF317;IMPDH1A;DMRTA1;NUDT19;ATMIN
protein bindingASB2;BBS9;ENG;OSBPL1A;MRPS12;NR2E3;KIF3A;AK8;NOD1

RASSF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF5.

STK3; STK4; MAP1LC3B; HRAS

Guo, W; Wang, C; et al. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. CLINICAL & EXPERIMENTAL METASTASIS 32:83-98(2015).
Schmidt, ML; Donninger, H; et al. Ras Regulates SCF beta-TrCP Protein Activity and Specificity via Its Effector Protein NORE1A. JOURNAL OF BIOLOGICAL CHEMISTRY 289:31102-31110(2014).
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