rassf5
Share
  • Official Full Name
  • Ras association (RalGDS/AF-6) domain family member 5
  • Background
  • This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • RASSF5; Ras association (RalGDS/AF-6) domain family member 5; RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3; MGC10823; MGC17344; Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; OTTHUMP00000034534; OTTHUMP00000034535; Rap1-binding protein; Ras association (RalGDS/AF-6) domain family 5; Ras effector-like protein; novel Ras effector 1; tumor suppressor RASSF3
Cat.#:RASSF5-1071HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RASSF5, GST-tagged
+Inquiry
Cat.#:RASSF5-29658THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RASSF5, His-tagged
+Inquiry
Cat.#:RASSF5-29726THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RASSF5
+Inquiry
Cat.#:RASSF5-5443HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RASSF5, MYC/DDK-tagged
+Inquiry
Cat.#:RASSF5-13967MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RASSF5 Protein
+Inquiry
Cat.#:RASSF5-1830CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RASSF5
+Inquiry
Cat.#:RASSF5-2495HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RASSF5 293 Cell Lysate
+Inquiry

Involved Pathway

RASSF5 involved in several pathways and played different roles in them. We selected most pathways RASSF5 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
FGF19; PLA2G3; PIK3R5; RALB; RAC1; BRAP; RASA1; GAB1; PLA2G1B; IGF1R
Rap signaling pathway
RASSF5; BCAR1; RALGDS; NGF; PDGFC; Pdgfa&Pdgfb; FGF22; FGF4; NRAS; VEGFB
Leukocyte transendothelial migration
VCAM1; PTPN11; BCAR1; CLDN2; CLDN16; VASP; THY1; RAC2; MYLPF; MMP2
Pathways in cancer
CTBP2; GNG5; CKS2; DAPK3; PIK3R1; CDC42; KIT; CCND1; WNT16; FZD1
Non-small cell lung cancer
PDPK1; KRAS; PIK3R5; MAPK3; MAPK1; PIK3R2; PIK3CG; HRAS; PIK3CA; RASSF1

Protein Function

RASSF5 has several biochemical functions, for example, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF5 itself. We selected most functions RASSF5 had, and list some proteins which have the same functions with RASSF5. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein TRIM101; ZNF165; RPAIN; ACAT1; PPP4CA; PPM1DB; USP4; ATP1A1A.1; PDE1B; ZNF584
Function protein binding
Related Protein OPRL1; DEAF1; ZCCHC11; EPN1; RAB3IP; ZNF207; ZNRF1; ZNF114; ADAM33; CLTA

Interacting Protein

RASSF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF5.
STK3; STK4; MAP1LC3B; HRAS

RASSF5 Related Articles

Guo, W; Wang, C; et al. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. CLINICAL & EXPERIMENTAL METASTASIS 32:83-98(2015).
Schmidt, ML; Donninger, H; et al. Ras Regulates SCF beta-TrCP Protein Activity and Specificity via Its Effector Protein NORE1A. JOURNAL OF BIOLOGICAL CHEMISTRY 289:31102-31110(2014).