This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described.
RDH13; retinol dehydrogenase 13 (all-trans/9-cis); retinol dehydrogenase 13 (all trans and 9 cis); retinol dehydrogenase 13; SDR7C3; short chain dehydrogenase/reductase family 7C; member 3; RDH13_HUMAN; Retinol dehydrogenase 13 (all trans/9 cis); retinol dehydrogenase 13 (all-trans and 9-cis); short chain dehydrogenase/reductase family 7C, member 3
RDH13 involved in several pathways and played different roles in them. We selected most pathways RDH13 participated on our site, such as RA biosynthesis pathway, Signal Transduction, Signaling by Retinoic Acid, which may be useful for your reference. Also, other proteins which involved in the same pathway with RDH13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
RDH13 has several biochemical functions, for example, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RDH13 itself. We selected most functions RDH13 had, and list some proteins which have the same functions with RDH13. You can find most of the proteins on our site.
Function oxidoreductase activity
Related Protein CYP26C1; MICAL2; CYP8B2; KDM1B; DHRS13A.3; CYP8B1; SOD3A; CYBASC3; RDH14A; CYP1C2
RDH13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RDH13 here. Most of them are supplied by our site. Hope this information will be useful for your research of RDH13.
GADD45G; PSKH1; CYP3A5; 1C; SLC25A5; COA3
RDH13 Related Articles
Crosas, B; Hyndman, DJ; et al. Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. BIOCHEMICAL JOURNAL 373:973-979(2003).
Brodeur, H; Gagnon, I; et al. Cloning of monkey RALDH1 and characterization of retinoid metabolism in monkey kidney proximal tubule cells. JOURNAL OF LIPID RESEARCH 44:303-313(2003).