reln
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  • Official Full Name
  • Reelin
  • Background
  • This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for;cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia,;autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations;of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants;encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their;full length nature has not been determined.
  • Synonyms
  • RELN; reelin; RL; LIS2; PRO1598; EC 3.4.21.; OT-THUMP00000211831; OTTHUMP00000211830
Cat.#:RELN-8060HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RELN protein, His & T7-tagged
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Cat.#:RELN-8061HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RELN protein, His & T7-tagged
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Cat.#:RELN-8062HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RELN protein, His & T7-tagged
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Cat.#:Reln-655MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Reln Protein, His-tagged
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Cat.#:Reln-8063MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Reln protein, His & S-tagged
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Cat.#:RELN-4993RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RELN Protein
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Cat.#:Reln-8064RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Reln protein, His & S-tagged
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Cat.#:RELN-8094ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RELN
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Involved Pathway

RELN involved in several pathways and played different roles in them. We selected most pathways RELN participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RELN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
AKT1; PDGFD; IRS1; PRL; F2R; GNB3; CCNE1; G6PC2; PPP2R5B; IFNA2
Focal adhesion
PPP1CC; LAMA5; PDGFAB; DIAP1; RAF1B; COL27A1; LAMA3; PDGFRB; SOS1; SPP1
ECM-receptor interaction
ITGA4; SPP1; COL1A2; COL6A2; GP1BA; COL11A2; ITGA3; CD36; DAG1; LAMA5

Protein Function

RELN has several biochemical functions, for example, hydrolase activity, lipoprotein particle receptor binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RELN itself. We selected most functions RELN had, and list some proteins which have the same functions with RELN. You can find most of the proteins on our site.
Function
Related Protein
Function hydrolase activity
Related Protein POR; DNASE2A; HTRA1A; PEO1; CTSJ; CNOT6L; URAH; ATP6V0E; CTSL.1; CTSBB
Function lipoprotein particle receptor binding
Related Protein APOA5; LRP1; Reln
Function metal ion binding
Related Protein LTN1; EXTL2; PRKCBB; NT5C2L1; ESCO2; ZFP628; ITGA10; REPIN1; ADAR; ARMC1L
Function peptidase activity
Related Protein UFSP2; OTUD4; MCPT1; MMP14B; DUB1; GZMF; MASP1; CAPN3A; MEP1A.1; TMPRSS11F
Function protein binding
Related Protein LYN; CTAG2; Tnfrsf23; CASP1; RASL11A; CHMP2A; ATPAF2; GNA13; MOB4; TBC1D24
Function serine-type peptidase activity
Related Protein MCPT8; HPN; PRSS8; ELA2L; PRSS59.1; KLK7; GZMC; PRSS48; C1rb; DPP8
Function very-low-density lipoprotein particle receptor binding
Related Protein APOEB; PCSK9; APOEA; LRPAP1; Reln; APOE

RELN Related Articles

Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
Ramirez, AEG; Martinez, AD; et al. Epigenetics and twin studies in psychiatric domains. SALUD MENTAL 31:229-237(2008).