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RELN

Official Full Name

Reelin
Overview

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for;cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia,;autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations;of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants;encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their;full length nature has not been determined.
Synonyms

RELN; reelin; RL; LIS2; PRO1598; EC 3.4.21.; OT-THUMP00000211831; OTTHUMP00000211830;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Mammalian cells
Yeast

Tag

His
His (Fc)
Avi
His|S
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RELN-8060H	Recombinant Human RELN protein, His & T7-tagged	E.coli	His/T7	Glu3142~Pro3460 (Accession # P78509)	Inquiry
Human	RELN-8062H	Recombinant Human RELN protein, His & T7-tagged	E.coli	His/T7	Ala26~Pro190 (Accession # P78509)	Inquiry
Human	RELN-8061H	Recombinant Human RELN protein, His & T7-tagged	E.coli	His/T7	Glu2398~Leu2608 (Accession # P78509)	Inquiry
Human	RELN-3217H	Recombinant Human RELN protein, His-tagged	E.coli	His	315-508 aa	$319 / 25ug
Human	RELN-1504H	Recombinant Human RELN Protein (26-254 aa), His-tagged	Yeast	His	26-254 aa	Inquiry
Human	RELN-3422H	Recombinant Human RELN protein, His-tagged	E.coli	His	26-254aa	Inquiry
Human	RELN-2651H	Recombinant Human RELN Protein, His-tagged	E.coli	N-His	Asp2978-Val3373	Inquiry
Mouse	Reln-655M	Active Recombinant Mouse Reln Protein, His-tagged	Mammalian cells	His	Leu1221-Ile2661	Inquiry
Mouse	Reln-8063M	Recombinant Mouse Reln protein, His & S-tagged	E.coli	His/S	Glu3143~Pro3461 (Accession # Q60841)	Inquiry
Mouse	Reln-7520M	Recombinant Mouse Reln Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Reln-7520M-B	Recombinant Mouse Reln Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Reln-8064R	Recombinant Rat Reln protein, His & S-tagged	E.coli	His/S	Glu2400~Leu2610 (Accession # P58751)	Inquiry
Rat	RELN-4993R	Recombinant Rat RELN Protein	Mammalian Cell	His		Inquiry
Rat	RELN-4652R-B	Recombinant Rat RELN Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	RELN-4652R	Recombinant Rat RELN Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	RELN-8094Z	Recombinant Zebrafish RELN	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RELN Related Articles

RELN involved in several pathways and played different roles in them. We selected most pathways RELN participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RELN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
PIK-Akt signaling pathway	RELA;TSC2;FGF5;LPAR6;DDIT4;IL4;IFNA5;PIK3CG;FGF6
Focal adhesion	MAPK6;HGF;SPP1;RHOAD;RHOAC;PIP5K1C;FYNA;BCL2A;COL5A1
ECM-receptor interaction	COL4A3;TNN;LAMB4;SPP1;ITGA11A;GP1BA;LAMA3;Itga10&Itgb1;COL5A2

RELN has several biochemical functions, for example, hydrolase activity, lipoprotein particle receptor binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RELN itself. We selected most functions RELN had, and list some proteins which have the same functions with RELN. You can find most of the proteins on our site.

Function	Related Protein
hydrolase activity	FAHD2B;HE1A;ABHD16B;HTRA1B;MBTPS2;PPM1LA;C6AST4;MTMR7A;TRY
lipoprotein particle receptor binding	Reln;LRP1;APOA5
metal ion binding	ZFYVE27;ZDHHC5A;DPYD;ZFP583;CYP2P6;TRIM101;SALL1A;SMAP2;DNAJA2L
peptidase activity	SHHA;KLK1B26;MASP2;PLAUA;HTRA2;ADAM25;PAPPAB;CTSSA;CAPN2A
protein binding	SLAMF6;CCDC106;FAM131C;BPTF;CSF2RB;SUPT4H1;MAPK11;SEPT11;UBE3A
serine-type peptidase activity	DPP6;HTRA1B;TMPRSS11F;PLAUB;Gzmd;SEC11C;SLC38A8;TMPRSS11E;GZME
very-low-density lipoprotein particle receptor binding	APOE;LRPAP1;APOEA;Reln;APOEB;PCSK9

RELN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RELN here. Most of them are supplied by our site. Hope this information will be useful for your research of RELN.

Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).

Ramirez, AEG; Martinez, AD; et al. Epigenetics and twin studies in psychiatric domains. SALUD MENTAL 31:229-237(2008).