Recombinant Human RELN Protein (26-254 aa), His-tagged

• Cat.No.: RELN-1504H
• Product Overview: Recombinant Human RELN Protein (26-254 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cell Adhesion. Protein Description: Partial.

Specification

• Description: Extracellular domain matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it ses to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the Extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 26.9 kDa
• Protein length: 26-254 aa
• AA Sequence: AAGYYPRFSPFFFLCTHHGELEGDG EQGEVLISLHIAGNPTYYVPGQEYH VTISTSTFFDGLLVTGLYTSTSVQA SQSIGGSSAFGFGIMSDHQFGNQFM CSVVASHVSHLPTTNLSFIWIAPPA GTGCVNFMATATHRGQVIFKDALAQ QLCEQGAPTDVTVHPHLAEIHSDSI ILRDDFDSYHQLQLNPNIWVECNNC ETGEQCGAIMHGNAVTFCEPYGPRE LITT
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: RELN reelin [ Homo sapiens ]
• Official Symbol: RELN
• Synonyms: RELN; reelin; PRO1598; RL; LIS2
• Gene ID: 5649
• mRNA Refseq: NM_005045
• Protein Refseq: NP_005036
• MIM: 600514
• UniProt ID: P78509