rgs2
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  • Official Full Name
  • regulator of G-protein signaling 2, 24kDa
  • Background
  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins;(GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of;the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of;G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a;role in leukemogenesis.
  • Synonyms
  • RGS2; regulator of G-protein signaling 2, 24kDa; G0S8, regulator of G protein signalling 2, 24kD , regulator of G protein signalling 2, 24kDa; regulator of G-protein signaling 2; G0/G1 switch regulatory protein 8; cell growth-inhibiting protein 31; G0 t
Cat.#:RGS2-190HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS2 protein, T7-tagged
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Cat.#:RGS2-2278HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS2, GST-tagged
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Cat.#:RGS2-2979HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS2, T7-tagged
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Cat.#:RGS2-29964THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS2
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Cat.#:RGS2-29965THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS2, T7 -tagged
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Cat.#:RGS2-3484HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS2, His-tagged
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Cat.#:RGS2-5018RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RGS2 Protein
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Cat.#:RGS2-3875RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RGS2 Protein, His-tagged
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Cat.#:RGS2-5965CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RGS2
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Cat.#:RGS2-772ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RGS2
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Cat.#:RGS2-2378HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RGS2 293 Cell Lysate
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Involved Pathway

RGS2 involved in several pathways and played different roles in them. We selected most pathways RGS2 participated on our site, such as cGMP-PKG signaling pathway, Olfactory transduction, Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
CALML5; SLC8A2; AGTR1A; ATP1A3; PPP3R2; PPP3CA; PIK3CD; IRS2; GNA12; AGTR1B
Olfactory transduction
OR6B2; CALM2; OLFR15; OR2B3; OR2J3; OR5V1; OR8B8; OR7C1; OLFR1013; OLFR486
Oxytocin signaling pathway
ACTG1; ROCK2; PLA2G4F; CACNA2D4; CACNA2D2; MYL9; CACNG4; PLA2G4C; RYR1; CALM4

Protein Function

RGS2 has several biochemical functions, for example, GTPase activator activity, beta-tubulin binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS2 itself. We selected most functions RGS2 had, and list some proteins which have the same functions with RGS2. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein RP2; ARHGDIA; AGFG1; RAP1GDS1; TBC1D15; RAP1GAP2; ARHGAP19; HTR2B; DOCK4; GRTP1
Function beta-tubulin binding
Related Protein BBS4; PIFO; PACRG; GABARAPL1; PDCD5; VAPB; PROL1; PEX14; HTT; RACGAP1
Function calmodulin binding
Related Protein PLA2G6; PHKG1B; MKNK1; AEBP1; MYLK2; PNCK; MYO1A; MYO5B; CAMK2D2; DAPK1
Function protein binding
Related Protein DSCC1; NME2; EPS8; PRDX3; MYCBP; KLK8; IL33; NDUFS3; BAZ1A; CCL5

Interacting Protein

RGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS2.
LRRK2; MTUS2; PARK2; CTSB; HSPA8; PRKCSH; DYNLL1; DDR1

RGS2 Related Articles

Calipari, ES; Sun, HG; et al. Amphetamine Self-Administration Attenuates Dopamine D2 Autoreceptor Function. NEUROPSYCHOPHARMACOLOGY 39:1833-1842(2014).
Puard, V; Tranchant, T; et al. Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 11:-(2013).