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RGS21

Official Full Name

regulator of G-protein signaling 21
Overview

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.
Synonyms

RGS21; regulator of G-protein signaling 21; regulator of G protein signalling 21; regulator of G-protein signalling 21;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RGS21-3615H	Recombinant Human RGS21, His-tagged	E.coli	His		Inquiry
Human	RGS21-29966TH	Recombinant Human RGS21, His-tagged	E.coli	His	152 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein

RGS21 involved in several pathways and played different roles in them. We selected most pathways RGS21 participated on our site, such as G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
G alpha (i) signalling events	SSTR5;SSTR3;APPB;LPAR2A;CCL35.1;TAS2R13;ADORA3;OXGR1A.1;OXGR1A.3
G alpha (q) signalling events	GPR65;QRFP;OPN4A;CYSLTR1;NPFFR2;NMB;ANXA1A;TRPC7;OPN4.1
GPCR downstream signaling	ARHGEF16;OPN1SW;S1PR3;KALRN;PNOC;NTS;CRHB;LPAR1;UTS2
Gastrin-CREB signalling pathway via PKC and MAPK	QRFP;ANXA1;MGLL;DGKA;QRFPR;OPN4A;TAC2;CCK;NMS
Signal Transduction	APLN;CRABP1;S1PR3;USP9;SOX4A;KIF7;ROR1;TAGAPA;LRP10
Signaling by GPCR	ARHGEF16;FGD4A;HCAR1-2;ARHGEF17;PENK;PRLH;FGD2;GPR18;GPR132B

RGS21 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS21 itself. We selected most functions RGS21 had, and list some proteins which have the same functions with RGS21. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	PGAM5;TBCD;TBC1D21;TBC1D10C;RASAL2;RINL;NF1;RAP1GAP;TBC1D25

RGS21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS21 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS21.