ripk1
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  • Official Full Name
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Background
  • Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.
  • Synonyms
  • RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP
Cat.#:RIPK1-202HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RIPK1 protein, GST-tagged, Active
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Cat.#:RIPK1-36HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK1, GST-tagged
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Cat.#:RIPK1-42HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RIPK1 protein, GST-tagged
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Cat.#:RIPK1-43HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human RIPK1 protein, His-tagged
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Cat.#:RIPK1-7018HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK1, GST-tagged
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Cat.#:RIPK1-14243MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ripk1 protein, His-tagged
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Cat.#:Ripk1-1264RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ripk1 protein, His-tagged
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Cat.#:RIPK1-5972CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RIPK1
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Cat.#:RIPK1-2334HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RIPK1 293 Cell Lysate
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Involved Pathway

RIPK1 involved in several pathways and played different roles in them. We selected most pathways RIPK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
Bcl2a1b; GM13304; CCL13; NFKB2; CD40; GM10591; TLR4; LTB; TRADD; MAP3K14
Apoptosis
IRF2; STK24; IRF4A; Gzmg; IL1B2; HRK; TICAM1; PIK3R3A; CFLARA; TRADD
Toll-like receptor signaling pathway
IRF5; PIK3CA; MAP2K4B; TBK1; MAPK9; IFNPHI3; TRAF3; IL12B; IFNA2; TLR2
RIG-I-like receptor signaling pathway
NFKB1; Ifna11; DDX3; IFNA4; IFNW1; AZI2; IFNA3; TANK; DDX58; RNF207B
Cytosolic DNA-sensing pathway
IL33; AIM2; NFKB1; IFNA13; IFNPHI3; IFNA10; POLR1C; MB21D1; IFNA3; POLR2K
TNF signaling pathway
VCAM1; PIK3R3; CXCL1; PTGS2; BIRC3; BAG4; IKBKG; CREB3L2; MAP2K4; MAP3K7IP3
Hepatitis C
GSK3B; RXRA; MAPK12; MAPK8; AKT2; TRAF2; TP53; EIF3E; MAPK9; CLDN6
Epstein-Barr virus infection
TAB2; PLCG1; GSK3B; VIM; PSMD1; HSPB2; POLR3GL; PLCG2; PIK3CB; HSPB1

Protein Function

RIPK1 has several biochemical functions, for example, ATP binding, death domain binding, death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK1 itself. We selected most functions RIPK1 had, and list some proteins which have the same functions with RIPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX41; MYO1G; P2RX4; CDK15; RAD54L; PFKMA; OXSR1B; PAPSS2B; TEK; UBE2J2
Function death domain binding
Related Protein CRADD; DAP1B; DAP; RIPK1; TRADD; DAPL1
Function death receptor binding
Related Protein TNFSF15; FADD; PIDD1; Fasl; FASLG; RIPK1; Casp3; BID; MYD88; PRDM4
Function identical protein binding
Related Protein ADIPOQ; RASSF3; BRAF; ALS2CL; GBP1; TPRG1L; B2M; MCIN; CAV1; BCAT1
Function protein binding
Related Protein MPPED2; SPRY4; LUC7L; TNFAIP8L1; TMEM173; ATN1; DMAP1; COQ9; ZNF274; CD46
Function protein complex binding
Related Protein WASF2; CTSL2; STK11; AP2B1; SHARPIN; Apba1; PPARA; OTOF; CAV3; GNB2
Function protein kinase activity
Related Protein PRKCDA; LIMK1; LMTK3; LTK; CSNK1G2A; NPR1A; PRKCHA; MAP2K1; CDKL5; MAPKAPK2
Function protein serine/threonine kinase activity
Related Protein TESK2; C9orf96; MAP3K14; TSSK4; VRK2; TSSK3; MLKL; HUNK; SGK2A; NLK
Function ubiquitin protein ligase binding
Related Protein SMC6; ATXN3; PACRG; Fzd4; ARIH1; HSPA1A; HM13; TCP1; UBE2G1B; MFN2

Interacting Protein

RIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK1.
CASP8