ripk1
Share
  • Official Full Name
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Background
  • Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.
  • Synonyms
  • RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP
Cat.#:RIPK1-202HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RIPK1 protein, GST-tagged, Active
+Inquiry
Cat.#:RIPK1-36HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK1, GST-tagged
+Inquiry
Cat.#:RIPK1-42HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RIPK1 protein, GST-tagged
+Inquiry
Cat.#:RIPK1-43HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human RIPK1 protein, His-tagged
+Inquiry
Cat.#:RIPK1-7018HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK1, GST-tagged
+Inquiry
Cat.#:RIPK1-14243MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ripk1 protein, His-tagged
+Inquiry
Cat.#:Ripk1-1264RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ripk1 protein, His-tagged
+Inquiry
Cat.#:RIPK1-5972CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RIPK1
+Inquiry
Cat.#:RIPK1-2334HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RIPK1 293 Cell Lysate
+Inquiry

Involved Pathway

RIPK1 involved in several pathways and played different roles in them. We selected most pathways RIPK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
RELA; IRAK1; CXCL12; CCL4L1; BCL2; BLNK; ATM; PLAU; CARD11; TNFSF14
Apoptosis
H1F0; AKT1; PRKACBB; SATB1; BNIP3LB; BIDA; BCL2L1; CRADD; CAPN2A; FAS
Toll-like receptor signaling pathway
CCL4L2; IFNPHI3; STAT1A; MAPK3; TAB2; MAP2K3; MAP2K1; TLR2-1; MYD88; CXCL9
RIG-I-like receptor signaling pathway
MAPK11; DAK; IFNA12; IFNA14; IFNA1; IFNK; IKBKG; TRIM25; IL-8; MAPK12A
Cytosolic DNA-sensing pathway
RELA; IL18; POLR3C; IL6; POLR3D; Ifna11; POLR1C; NFKBIB; IFNPHI1; POLR2E
TNF signaling pathway
IL15; PIK3CB; CXCL10; CREB3L2; IKBKB; SELE; MAPK9; CASP7; BAG4; MAPK1
Hepatitis C
CLDN1; IKBKE; KRAS; MAPK11; CLDN4; OAS1B; CLDN23; CLDN20; EIF2AK2; NR1H3
Epstein-Barr virus infection
MAP2K4; AKT1; RBPJL; PSMC6; NFKBIA; PLCG1; CD38; TRAF6; HLA-DRB1; PIK3R3

Protein Function

RIPK1 has several biochemical functions, for example, ATP binding, death domain binding, death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK1 itself. We selected most functions RIPK1 had, and list some proteins which have the same functions with RIPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DHX8; CIT; Acsm2a; P2RX5; ERBB4A; ATP4A; YES1; SGK2; ATP2B3A; CDK2
Function death domain binding
Related Protein DAP1B; DAP; DAPL1; CRADD; RIPK1; TRADD
Function death receptor binding
Related Protein MYD88; PRDM4; RIPK1; FADD; TMBIM1; FEM1B; PIDD1; Fasl; NOL3; CFLAR
Function identical protein binding
Related Protein ADIPOQ; TMEM115; ESYT2; E2F7; GUCY2E; CBX3; BNIPL; IGF2R; SAFB2; TFRC
Function protein binding
Related Protein NKX2; TOR1B; SKP2; SFRP1; RNF10; TTC3; TDRD9; AGPAT5; ZNF567; TLR4
Function protein complex binding
Related Protein DRD1A; STRN4; PDZK1; LRP2; CTSL2; PTCH1; RIPK1; SKAP1; PROS1; KAT6B
Function protein kinase activity
Related Protein TBK1; PRKACAB; CAMK2B1; LRRK2; SLKA; CAMK1GB; GC3; CAMKVB; PTK2AB; EEF2K
Function protein serine/threonine kinase activity
Related Protein NEK6; RPS6KB1B; TNK2; MAP3K12; PIK3R4; STK33; CAMKK1A; RAF1A; CLK1; DAPK3
Function ubiquitin protein ligase binding
Related Protein LYN; CUL1; SPG20; MOAP1; SQSTM1; UBE2G2; KCNQ3; RFFL; AKTIP; RB1

Interacting Protein

RIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK1.
CASP8