Active Recombinant Full Length Human RIPK1, GST-tagged
Cat.No. : | RIPK1-36H |
Product Overview : | Full-length recombinant human RIPK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Description : | RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process. TNFalpha is capable of activating the noncanonical NF-kB pathway, but this activation of this pathway is negatively regulated by RIPK1. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 3.5 nmol/min/mg |
Molecular Mass : | ~108 kDa |
Applications : | Kinase Assay, Western Blot |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05ug/ul |
Protein length : | 1-671 a.a. |
Gene Name : | RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 [ Homo sapiens ] |
Official Symbol : | RIPK1 |
Synonyms : | RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP; RIP1; FLJ39204; |
Gene ID : | 8737 |
mRNA Refseq : | NM_003804 |
Protein Refseq : | NP_003795 |
MIM : | 603453 |
UniProt ID : | Q13546 |
Chromosome Location : | 6p25.2 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; |
Function : | ATP binding; death domain binding; death receptor binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
RIPK1-1200H | Recombinant Human RIPK1 Protein (M1-A327), Tag Free | +Inquiry |
RIPK1-1201H | Recombinant Human RIPK1 Protein (M1-A327), His/GST tagged | +Inquiry |
RIPK1-19D | Recombinant Active Dog RIPK1 Protein (1-327), N-GST-tagged | +Inquiry |
RIPK1-2252M | Recombinant Full Length Mouse RIPK1 Protein (1-656 aa), His-SUMOSTAR-tagged | +Inquiry |
RIPK1-21M | Recombinant Active Monkey RIPK1 Protein (1-373), N-GST-tagged | +Inquiry |
◆ Lysates | ||
RIPK1-2334HCL | Recombinant Human RIPK1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe proteins accepted were of very high purity and were put into experiments with satisfactory results.
Customer service was patient, prompt and accurate in answering my queries.
Prompt delivery, which helped me to obtain satisfactory experimental results in a short time.
Q&As (4)
Ask a questionRIPK1 is one of the most critical intracellular signaling factors mediating necrotic apoptosis.
Necrostatin-1 blocks RIPK1 phosphorylation.
Inhibition of RIPK1 reduces astrocyte proliferation and glial scar formation and promotes recovery of brain function.
RIPK1 is closely related to the study of stroke, neurodegenerative diseases, autoimmune diseases and other diseases.
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