rnf135
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  • Official Full Name
  • ring finger protein 135
  • Background
  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms
  • RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; L13; RIG-I E3 ubiquitin ligase; MMFD; REUL
Cat.#:RNF135-689HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RNF135 Protein, MYC/DDK-tagged
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Cat.#:RNF135-5071RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RNF135 Protein
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Cat.#:RNF135-1519HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNF135 cell lysate
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Involved Pathway

RNF135 involved in several pathways and played different roles in them. We selected most pathways RNF135 participated on our site, such as Immune System, Innate Immune System, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF135 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Immune System
TRIM14; TLR6; ARIH1L; TRIM11; OASL; KIF11; DEFA1; SIGLEC7; HLA-DQB2; AP1M2
Innate Immune System
BTR12; PELI2; CR1; PANX1; BTR30; NCKAP1; HBL3; CD300E; TANK; DEFA6
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
RNF135
Negative regulators of RIG-I/MDA5 signaling
TAX1BP1; PCBP2; NLRC5; RNF216; CYLD; RNF135; HERC5; TAX1BP1B
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
TAX1BP1; TANK; NLRC5; HERC5; RNF135; RNF216; TAX1BP1B; PCBP2
TRAF3-dependent IRF activation pathway
RNF135
TRAF6 mediated IRF7 activation
RNF135
TRAF6 mediated NF-kB activation
RNF135

Protein Function

RNF135 has several biochemical functions, for example, ligase activity, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF135 itself. We selected most functions RNF135 had, and list some proteins which have the same functions with RNF135. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein MKRN3; CPS1; RANBP2; BRCA1; RTCB; TRIM33; UBE2NB; LIG4; ATG3; UBR1
Function protein binding
Related Protein STARD13; GSK3B; VENTX; WHSC2; RAD21; BCAR1; NOV; CNIH4; PLD1; ILVBL
Function ribonucleoprotein complex binding
Related Protein SECISBP2; CD2BP2; PRMT5; PIGC; PPIH; WDR12; RNF135; UHMK1; RNASEL; ITCH
Function ubiquitin-protein transferase activity
Related Protein FBXO30A; FEM1A; RNF6; UBA7; FBXO40.1; ANKIB1A; ANKIB1; RNF41; ZFP91; RNF182
Function zinc ion binding
Related Protein OAS1A; ZFAND3; FBXO11; POLR1A; NR2C1; MT2; ABLIM1B; PTGR1; RNF34B; PITRM1

Interacting Protein

RNF135 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF135 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF135.
GOLGA2; CTNNAL1; UBA1; UBE2N; UBE2V1; TACC3