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RNF135

Official Full Name

ring finger protein 135
Overview

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms

RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; L13; RIG-I E3 ubiquitin ligase; MMFD; REUL;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E. coli
E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RNF135-689H	Recombinant Human RNF135 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	RNF135-1519HCL	Recombinant Human RNF135 cell lysate		N/A		Inquiry
Human	RNF135-0410H	Recombinant Human RNF135 Protein (A2-V432), Tag Free	E.coli	No tag	A2-V432	Inquiry
Human	RNF135-501H	Recombinant Human RNF135 protein, His-tagged	E. coli	His	1-210 aa	Inquiry
Human	RNF135-0411H	Recombinant Human RNF135 Protein (A2-V432), His tagged	E.coli	His	A2-V432	Inquiry
Mouse	Rnf135-5546M	Recombinant Mouse Rnf135 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	RNF135-5071R	Recombinant Rat RNF135 Protein	Mammalian Cell	His		Inquiry
Rat	RNF135-4730R	Recombinant Rat RNF135 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RNF135-4730R-B	Recombinant Rat RNF135 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

RNF135 involved in several pathways and played different roles in them. We selected most pathways RNF135 participated on our site, such as Immune System, Innate Immune System, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF135 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Immune System	ASB2;ASB8;MICA;CD200R4;NA;CD300E;IFI30;KIF2A;ERAP1
Innate Immune System	PANX1A;CTSK;DEFB103A;DEFA1;WIPF2;BTR30;NLRP4B;LRRFIP1;MGC174152
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of RIG-I/MDA5 signaling	PCBP2;TAX1BP1;NLRC5;RNF135;TAX1BP1B;CYLD;HERC5;RNF216
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	RNF216;RNF135;TAX1BP1B;HERC5;PCBP2;NLRC5;TAX1BP1;TANK
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation

RNF135 has several biochemical functions, for example, ligase activity, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF135 itself. We selected most functions RNF135 had, and list some proteins which have the same functions with RNF135. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	MARCH6;TMEM129;PET112L;E4F1;MARCH4;RNF149;MARCH5;RNF43;PIAS1
protein binding	KRT14;DUSP2;GJA1;RAD23A;NBR1;MSX2;VSIG4;NLRC4;CDC73
ribonucleoprotein complex binding	PES;YBX2;PITX2;WDR12;PQBP1;PES1;PPIH;PRMT5;ITCH
ubiquitin-protein transferase activity	FEM1A;UBE2M;TRIM24;RNF43;UBE2Q2;FBXL5;CBL;PDZRN3B;TRIM13
zinc ion binding	GATA6;ZCCHC18;ZGLP1;ZCCHC3;NR2E3;ADAM9;LIMK1A;ZFML;BTR29

RNF135 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF135 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF135.

GOLGA2; CTNNAL1; UBA1; UBE2N; UBE2V1; TACC3