|Official Full Name||ring finger protein 135|
|Background||The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.|
|Synonyms||RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; L13; RIG-I E3 ubiquitin ligase; MMFD; REUL|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RNF135 involved in several pathways and played different roles in them. We selected most pathways RNF135 participated on our site, such as Immune System, Innate Immune System, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF135 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Immune System||ASB13; ADAR; CNPY3; TRIM8; MICA; HBL3; SIGLEC9; TRIM56; MGC174155; LILRA3|
|Innate Immune System||CRP; CFHL2; IRAK3; POLR3F; TANK; CTSLL; PANX1; POLR3GLA; PPAPDC1A; ACTR2B|
|NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10||RNF135|
|Negative regulators of RIG-I/MDA5 signaling||RNF135; CYLD; NLRC5; RNF216; TAX1BP1; TAX1BP1B; PCBP2; HERC5|
|RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways||TANK; RNF135; TAX1BP1B; HERC5; NLRC5; TAX1BP1; PCBP2; RNF216|
|TRAF3-dependent IRF activation pathway||RNF135|
|TRAF6 mediated IRF7 activation||RNF135|
|TRAF6 mediated NF-kB activation||RNF135|
RNF135 has several biochemical functions, for example, ligase activity, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF135 itself. We selected most functions RNF135 had, and list some proteins which have the same functions with RNF135. You can find most of the proteins on our site.
|ligase activity||NAPRT1; RNF185; RFWD2; MKRN3; KCNG4; RNF220; TRIM8; RAG1; MGRN1; PRPF19|
|protein binding||CCNE1; ELP3; CHMP1B; TMIGD2; HOOK3; COL3A1; MAGEB18; PPARGC1A; SND1; MX2|
|ribonucleoprotein complex binding||RNF135; PRPF6; PRMT5; SRP54; PRMT7; PIGC; BOP1; ITCH; PPIH; PES1|
|ubiquitin-protein transferase activity||UBR1; TRIM27; MARCH1; ZFP91; MARCH6; UBE3A; UBE2L6; ZNRF1; BIRC3; UBE2E2|
|zinc ion binding||WT1; NR5A5; SIAH2L; ADAM30; NR2F6; BTR12; PHF13; OTUD7B; PHF20B; SIRT3|
RNF135 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF135 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF135.
GOLGA2; CTNNAL1; UBA1; UBE2N; UBE2V1; TACC3