RNF135 Protein, ring finger protein 135

RNF135

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RNF135

Official Full Name ring finger protein 135
Background The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; L13; RIG-I E3 ubiquitin ligase; MMFD; REUL
    • Species :
    • Human
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF135-1519HCL Recombinant Human RNF135 cell lysate N/A
    Human RNF135-689H Recombinant Human RNF135 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Rat RNF135-5071R Recombinant Rat RNF135 Protein Mammalian Cell His

    RNF135 involved in several pathways and played different roles in them. We selected most pathways RNF135 participated on our site, such as Immune System, Innate Immune System, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF135 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System ASB13; ADAR; CNPY3; TRIM8; MICA; HBL3; SIGLEC9; TRIM56; MGC174155; LILRA3
    Innate Immune System CRP; CFHL2; IRAK3; POLR3F; TANK; CTSLL; PANX1; POLR3GLA; PPAPDC1A; ACTR2B
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 RNF135
    Negative regulators of RIG-I/MDA5 signaling RNF135; CYLD; NLRC5; RNF216; TAX1BP1; TAX1BP1B; PCBP2; HERC5
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TANK; RNF135; TAX1BP1B; HERC5; NLRC5; TAX1BP1; PCBP2; RNF216
    TRAF3-dependent IRF activation pathway RNF135
    TRAF6 mediated IRF7 activation RNF135
    TRAF6 mediated NF-kB activation RNF135

    RNF135 has several biochemical functions, for example, ligase activity, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF135 itself. We selected most functions RNF135 had, and list some proteins which have the same functions with RNF135. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity NAPRT1; RNF185; RFWD2; MKRN3; KCNG4; RNF220; TRIM8; RAG1; MGRN1; PRPF19
    protein binding CCNE1; ELP3; CHMP1B; TMIGD2; HOOK3; COL3A1; MAGEB18; PPARGC1A; SND1; MX2
    ribonucleoprotein complex binding RNF135; PRPF6; PRMT5; SRP54; PRMT7; PIGC; BOP1; ITCH; PPIH; PES1
    ubiquitin-protein transferase activity UBR1; TRIM27; MARCH1; ZFP91; MARCH6; UBE3A; UBE2L6; ZNRF1; BIRC3; UBE2E2
    zinc ion binding WT1; NR5A5; SIAH2L; ADAM30; NR2F6; BTR12; PHF13; OTUD7B; PHF20B; SIRT3

    RNF135 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF135 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF135.

    GOLGA2; CTNNAL1; UBA1; UBE2N; UBE2V1; TACC3

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