Recombinant Human RNF135 cell lysate

• Cat.No.: RNF135-1519HCL

Specification

• Description: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: RNF135 ring finger protein 135 [ Homo sapiens ]
• Official Symbol: RNF135
• Synonyms: RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; RIG-I E3 ubiquitin ligase; L13; MMFD; REUL; Riplet
• Gene ID: 84282
• mRNA Refseq: NM_001184992
• Protein Refseq: NP_001171921
• MIM: 611358
• UniProt ID: Q8IUD6
• Chromosome Location: 17q11.2
• Pathway: Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem; TRAF3-dependent IRF activation pathway, organism-specific biosystem; TRAF6 mediated IRF7 activation, organism-specific biosystem
• Function: ligase activity; metal ion binding; protein binding; ribonucleoprotein complex binding; ubiquitin-protein ligase activity; zinc ion binding