|Official Full Name||ring finger protein 139|
|Background||The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as withCOPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.|
|Synonyms||RNF139; ring finger protein 139; E3 ubiquitin-protein ligase RNF139; HRCA1; RCA1; TRC8; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; translocation in renal carcinoma on chromosome 8 protein; MGC31961|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RNF139 involved in several pathways and played different roles in them. We selected most pathways RNF139 participated on our site, such as SREBP signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF139 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|SREBP signalling||INSIG1; RBP4; DBI; SEC23B; INSIG2; RNF139|
RNF139 has several biochemical functions, for example, ligase activity, protease binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF139 itself. We selected most functions RNF139 had, and list some proteins which have the same functions with RNF139. You can find most of the proteins on our site.
|ligase activity||TRAIP; TRIML1; PELI1; TNFAIP3; MDM2; MARCH6; KCNG4; EGR2; NAPRT1; ITCHA|
|protease binding||THAP5; FURIN; STIM1; F3; SELL; SEMG2; MBP; CD28; SERPINB6; CHL1|
|protein binding||DOCK1; PTH2R; CST3; TAC3; TMEM67; OXR1; HNRNPK; LINC00482; MTMR7; ACAT2|
|receptor activity||EXTL3; PVRL3; TLR3; LYVE1; TLR1; IL18R1; NPR2; FKBP3; SMAGP; ITGB4|
|ubiquitin protein ligase activity||ARIH1; MARCH8; TRAIP; RNF222; HECW2; RNF41; UBE3A; RNF144A; MED20; FBXO6|
|ubiquitin-like protein transferase activity||ATG3; UBL4A; RNF14; ARIH1; ATG16L1; RNF139|
|ubiquitin-protein transferase activity||RBCK1; FBXO22; ITCH; RNF125; PEX2; TRAF2; FBXL21; TOPORS; BRAP; UBE2W|
|zinc ion binding||L3MBTL1; TRAF3; UHRF1; THRA; TK1; ESRRB; DDX58; RSPRY1; MEX3C; APOBEC2B|
RNF139 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF139 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF139.
HM13; XBP1; VHL; UBE2H; UBE2U; UBE2Z