rnf139
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  • Official Full Name
  • ring finger protein 139
  • Background
  • The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as withCOPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
  • Synonyms
  • RNF139; ring finger protein 139; E3 ubiquitin-protein ligase RNF139; HRCA1; RCA1; TRC8; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; translocation in renal carcinoma on chromosome 8 protein; MGC31961
Cat.#:RNF139-14302MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNF139 Protein
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Cat.#:RNF139-3929RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RNF139 Protein, His-tagged
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Cat.#:RNF139-2643CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RNF139
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Cat.#:RNF139-6624ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RNF139
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Cat.#:RNF139-2297HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNF139 293 Cell Lysate
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Involved Pathway

RNF139 involved in several pathways and played different roles in them. We selected most pathways RNF139 participated on our site, such as SREBP signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF139 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
SREBP signalling
SEC23B; DBI; INSIG2; RNF139; RBP4; INSIG1

Protein Function

RNF139 has several biochemical functions, for example, ligase activity, protease binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF139 itself. We selected most functions RNF139 had, and list some proteins which have the same functions with RNF139. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein UBE3C; HECTD1; HECW1B; CBLC; PJA2; ADSSL; RNF216; MUL1; BARD1; TRIM56
Function protease binding
Related Protein Cstb; ITGB3; ANXA2; SERPINA1A; NFRKB; SERPINC1; RNF139; TIMP2; XBP1; CFLAR
Function protein binding
Related Protein SH2B1; RSPH3; KPNA2; LSAMP; LUZP4; USHBP1; CRCP; AF251705; C20orf20; CREM
Function receptor activity
Related Protein TNFRSF13B; CD86; PAQR3B; MED13; MED4; RTN4RL2; CMKLR1; KLRG1; CADM1A; TLR6
Function ubiquitin protein ligase activity
Related Protein MED23; ANKIB1A; UBE2V2; UBE3C; SMURF2; C12orf51; UBR1; UBR2; PDZRN3B; UBE2C
Function ubiquitin-like protein transferase activity
Related Protein UBL4A; ATG16L1; RNF14; ARIH1; ATG3; RNF139
Function ubiquitin-protein transferase activity
Related Protein PDZRN3; KLHL20; UBE2Q2; RBCK1; RNF168; TRIM13; HACE1; ZFP91; FBXO7; NHLRC1
Function zinc ion binding
Related Protein CA9; ZMAT5; ADAMTS20; RSPRY1; BRF1A; TAB3; CA12; PIAS3; UMPS; MT1M

Interacting Protein

RNF139 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF139 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF139.
HM13; XBP1; VHL; UBE2H; UBE2U; UBE2Z

RNF139 Related Articles

Wang, XW; Wei, W; et al. RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study. GUT AND LIVER 8:487-494(2014).
Kato, T; Franconi, CP; et al. Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation. CANCER GENETICS 207:133-140(2014).