rnf8
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  • Official Full Name
  • ring finger protein 8, E3 ubiquitin protein ligase
  • Background
  • The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
  • Synonyms
  • RNF8; ring finger protein 8, E3 ubiquitin protein ligase; hRNF8; E3 ubiquitin-protein ligase RNF8; C3HC4-type zinc finger protein; ring finger protein (C3HC4 type) 8; UBC13/UEV-interacting ring finger protein;
Cat.#:RNF8-14355MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNF8 Protein
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Cat.#:RNF8-5087RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RNF8 Protein
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Cat.#:RNF8-862CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RNF8 Protein, His-tagged
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Cat.#:RNF8-3948RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RNF8 Protein, His-tagged
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Cat.#:RNF8-11597ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RNF8
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Cat.#:RNF8-11777ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RNF8
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Cat.#:RNF8-2271HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNF8 293 Cell Lysate
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Involved Pathway

RNF8 involved in several pathways and played different roles in them. We selected most pathways RNF8 participated on our site, such as Apoptosis, Axon guidance, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
HMGB2; PPP3CA; PIK3R1; PPP3R1B; NMT1; PRKACA; PRKAR2A; CTNNB2; IL1B; BOKA
Axon guidance
SRGAP3; SPRED1; NTNG1; NTN1B; MYL12B; FRS3; RGMB; EPHB4A; EPHA7; GPC1B
Caspase activation via extrinsic apoptotic signalig pathway
RNF8; DCC; DAPK3; DAPK1; TICAM1; CASP8L1
Developmental Biology
AP2A1; EFNB3; LGI1B; CARM1; ARPC3; DOCK1; SCN2A; ACVR1C; COL6A1; MED7
Ligand-independent caspase activation via DCC
DAPK1; RNF8; DAPK3
Netrin mediated repulsion signals
RNF8; UNC5D
Netrin-1 signaling
RGMA; PITPNA; RGMB; EZRA; UNC5D; SIAH2; HFE2; TRPC4; TRPC5; RNF8
Programmed Cell Death
ADD1; STK24A; BCAP31; DIABLO; BAXB; DSG1; DSP; DSG3; GZME; DBNLA

Interacting Protein

RNF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF8.
MDC1; WASL; PNMA2; rnf8_bind_peptide