RNF8 Protein, ring finger protein 8, E3 ubiquitin protein ligase

RNF8

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RNF8

Official Full Name ring finger protein 8, E3 ubiquitin protein ligase
Background The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Synonyms RNF8; ring finger protein 8, E3 ubiquitin protein ligase; hRNF8; E3 ubiquitin-protein ligase RNF8; C3HC4-type zinc finger protein; ring finger protein (C3HC4 type) 8; UBC13/UEV-interacting ring finger protein;
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF8-2271HCL Recombinant Human RNF8 293 Cell Lysate HEK293 N/A
    Mouse RNF8-14355M Recombinant Mouse RNF8 Protein Mammalian Cell His
    Rat RNF8-5087R Recombinant Rat RNF8 Protein Mammalian Cell His
    Cynomolgus Monkey RNF8-862C Recombinant Cynomolgus RNF8 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque RNF8-3948R Recombinant Rhesus monkey RNF8 Protein, His-tagged Mammalian Cell His
    Zebrafish RNF8-11597Z Recombinant Zebrafish RNF8 Mammalian Cell His
    Zebrafish RNF8-11777Z Recombinant Zebrafish RNF8 Mammalian Cell His

    RNF8 involved in several pathways and played different roles in them. We selected most pathways RNF8 participated on our site, such as Apoptosis, Axon guidance, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis BAX; PRKACBB; PLEC; ATM; CASP8L1; CAPN2L; CFLAR; BAXB; BCAP31; PRKAR2B
    Axon guidance HBEGF; SRGAP3; GDNF; NTN4; EFNA3B; NRP1A; ACTR2B; PEBP1; EPHA3; CNTN1
    Caspase activation via extrinsic apoptotic signalig pathway DAPK1; TICAM1; RNF8; CASP8L1; DAPK3; DCC
    Developmental Biology EFNA2; RNF8; SCN9A; KIF4A; TDGF1; AP2A1; CAP1; MYL9; EFNB2; EBF1
    Ligand-independent caspase activation via DCC RNF8; DAPK1; DAPK3
    Netrin mediated repulsion signals RNF8; UNC5D
    Netrin-1 signaling TRPC5; NTN1B; EZRA; RNF8; SIAH2; RGMA; PITPNA; HFE2; NTN1A; TRPC4
    Programmed Cell Death RIPK3; CASP6L2; GZMC; SATB1; DSP; DAPK1; BCAP31; DIABLOA; PANK1A; GZME

    RNF8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RNF8 itself. We selected most functions RNF8 had, and list some proteins which have the same functions with RNF8. You can find most of the proteins on our site.

    Function Related Protein

    RNF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF8.

    MDC1; WASL; PNMA2; rnf8_bind_peptide

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