robo2
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  • Official Full Name
  • roundabout, axon guidance receptor, homolog 2 (Drosophila)
  • Background
  • The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
  • Synonyms
  • ROBO2; roundabout, axon guidance receptor, homolog 2 (Drosophila); SAX3; roundabout homolog 2;
Cat.#:ROBO2-9171ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ROBO2
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Cat.#:ROBO2-1225HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ROBO2 cell lysate
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Involved Pathway

ROBO2 involved in several pathways and played different roles in them. We selected most pathways ROBO2 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROBO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
RGMA; EPHB4B; CDK5; PHB; COL9A1A; EPHA2; MYL12A; PAK7; PAQR3B; GDNF

Protein Function

ROBO2 has several biochemical functions, for example, axon guidance receptor activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROBO2 itself. We selected most functions ROBO2 had, and list some proteins which have the same functions with ROBO2. You can find most of the proteins on our site.
Function
Related Protein
Function axon guidance receptor activity
Related Protein EPHB3; EPHA7; EPHB1; ROBO1; GFRA3; ROBO2; SEMA5A
Function identical protein binding
Related Protein SUN2; LDHB; SMAD6; STK10; LYZ; ATF3; PUF60; TP53; ITGB3; CLDN10
Function protein binding
Related Protein PPP6C; ZC3H11A; DLG4; ATM; MRPS31; TAF7; KRTAP23-1; RNF111; GLRB; ACAA1

Interacting Protein

ROBO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROBO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROBO2.
Dlg4; ROBO1; BNIP3L; RPS6KA5; OLFM2; HLA-DPB1; CPE; NR4A1; NR1H2; SSRP1; CENPU; yheI; KCNRG; RDH11; UBQLN4; PPP1R1B; KIF2A; KIF1C; MYC