rock1
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  • Official Full Name
  • Rho-associated, coiled-coil containing protein kinase 1
  • Background
  • ROCK-1, a 160 kDa small-GTP-effector protein, is a serine/threonine kinase involved in the induction of focal adhesions and stress fibers, and can play a major role in vascular smooth muscle contraction, malignant cell transformation, tumor invasion and m
  • Synonyms
  • ROCK1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated protein kinase 1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coil
Cat.#:ROCK1-420HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROCK1, GST-tagged
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Cat.#:ROCK1-552HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ROCK1
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Cat.#:ROCK1-574HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human ROCK1, GST-tagged
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Cat.#:ROCK1-76HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ROCK1 protein, Flag-tagged, Biotinylated
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Cat.#:ROCK1-14369MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ROCK1 Protein
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Cat.#:Rock1-15MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rock1 protein, His-tagged
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Cat.#:ROCK1-5094RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ROCK1 Protein
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Cat.#:ROCK1-3951RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ROCK1 Protein, His-tagged
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Cat.#:ROCK1-4314CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ROCK1
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Cat.#:ROCK1-8173ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ROCK1
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Cat.#:ROCK1-1480HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROCK1 (Active), GST-tagged
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Involved Pathway

ROCK1 involved in several pathways and played different roles in them. We selected most pathways ROCK1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
ATP2A2; PPP1CC; PLCB2; NFATC4; PPP3CB; MYLK; PLN; PIK3R2; AKT2; MAPK1
cAMP signaling pathway
GABBR2; ACOX1; ATP1B2; FSHR; RAC3; LIPE; GRIA3; HTR6; ATP1B3; PDE3B
Chemokine signaling pathway
CCL17; RHOA; GNB4; CRK; AKT1; CXCR4; CX3CR1; GRK1; CXCL8; WAS
Sphingolipid signaling pathway
SGMS2; RAC3; PLD1; TRAF2; PDPK1; GAB2; MAPK13; LASS1; LASS5; PIK3R3
Vascular smooth muscle contraction
AVPR1A; PLA2G4C; PLCB1; CYP4A14; PRKCB; CYP4A12A; ARAF; PLA2G2D; PLCB4; MYL9A
TGF-beta signaling pathway
MYCB; BAMBIA; THBS1; ACVR1C; NOG; BMP7; BMPR2A; TFDP1; FSTA; LEFTY1
Axon guidance
PITPNA; RND1L; EPHA2A; RGS3; AGRN; KALRN; RASGEF1A; RAC1; CLASP1; RASGRP4
Focal adhesion
ITGA6B; ITGB1A; MYLK2; STYK1; PTK6; COL11A2; MET; CDC42; TNK1; LAMA4
Platelet activation
VWF; PLCB2; GNAQ; PLCB4; ROCK2; ACTG1; ITPR3; PLA2G4A; MAPK13; AKT1
Leukocyte transendothelial migration
PRKCG; ACTG1; MMP9; CLDN10; AASS; CLDN22; ITGAL; ICAM1; ARHGAP35; VAV1
Regulation of actin cytoskeleton
PDGFAB; DIAPH3; MSNA; MYLPFA; PIK3CB; ABI2A; FGF12; BDKRB1; Itga10&Itgb1; RAC3A
Oxytocin signaling pathway
ACTB; HRAS; NOS3; PRKACG; GNAI3; RGS2; PLCB3; EEF2K; CACNA2D3; MYLK
Pathogenic Escherichia coli infection
CD14; EZR; NCL; TUBA3D; HCLS1; CTTN; ACTB; TUBA4A; TUBA1B; TUBA8
Shigellosis
PFN4; ABL1; MAPK11; WAS; NFKB1; PFN1; ATG5; U2AF1; MAPK12; DIAPH1
Salmonella infection
IL1B; PKN1; TLR4BB; PFN2; ARPC5A; CXCL2; DYNC1I2A; PFN4; MAPK3; ARPC5B
Pathways in cancer
DAPK3; FGF14; RAC1; DAPK2; Kitl; WNT3A; NTRK1; GNGT2; NFKB1; MLH1
Proteoglycans in cancer
WNT4; HPSE2; ROCK2; PPP1R12C; MAPK13; CD44; MMP2; PLAU; PPP1R12B; HCLS1
MicroRNAs in cancer
Abcb1b; MDM4; IKBKB; HMGA2; HRAS; ERBB2; CDC25B; RAF1; SHC4; CDC25C

Protein Function

ROCK1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK1 itself. We selected most functions ROCK1 had, and list some proteins which have the same functions with ROCK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ERCC2; CKMB; BAZ1B; GCLC; GALK2; PCXA; PPIP5K2; TESK1; TIMM44; DDX11
Function GTP-Rho binding
Related Protein KCTD13; PKN1; STXBP6; ROCK1; CDC42EP1; CDC42EP1B; TRIOBP; RTKN; CDC42EP3; EXOC1
Function metal ion binding
Related Protein GGPS1; FCNA; NGLY1; ZFP641; ACAP2; ANG3; COL10A1; XPA; CENPT; CYB561D2
Function protein binding
Related Protein Ctsl; NOTCH4; CEP44; DCP1A; RASL11A; C16orf59; NOS1; WRNIP1; PKP4; CCNDBP1
Function protein kinase activity
Related Protein FGFR1A; TBK1; FASTKD3; CAMK2D1; KDRL; NRBP1; PDPK1B; DYRK1A; SMOK2B; GRK1
Function protein serine/threonine kinase activity
Related Protein WNK2; OXSR1A; NEK6; MAP3K4; CAMK2B1; CAMK2D1; PLK3; AURKA; AKT2L; TESK1

Interacting Protein

ROCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK1.
RHOA; MAGEB4; LMO2; FAM124A; C6orf165; POLR3C; MYBPH

ROCK1 Related Articles

Ashley, N; Jones, M; et al. Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays. JOURNAL OF PATHOLOGY 234:34-45(2014).
Rentala, S; Chintala, R; et al. Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133(+)CD44(+) prostate cancer stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441:586-592(2013).