rps19
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  • Official Full Name
  • ribosomal protein S19
  • Background
  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
  • Synonyms
  • RPS19; ribosomal protein S19; 40S ribosomal protein S19; DBA; Diamond Blackfan anemia; S19; DBA1
Cat.#:RPS19-239HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ribosomal protein S19, His-tagged
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Cat.#:RPS19-2420HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS19, GST-tagged
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Cat.#:RPS19-29469THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RPS19
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Cat.#:RPS19-693HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS19 Protein, His-tagged
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Cat.#:RPS19-14475MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPS19 Protein
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Cat.#:RPS19-5156RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPS19 Protein
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Cat.#:RPS19-11013ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPS19
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Cat.#:RPS19-2169HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RPS19 293 Cell Lysate
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Involved Pathway

RPS19 involved in several pathways and played different roles in them. We selected most pathways RPS19 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome
MRPS18C; RPS6; RPS11; RPS17; RPS10-NUDT3; RPL28; RPL31; RPL10A; RPL18A; RPS4Y1

Protein Function

RPS19 has several biochemical functions, for example, fibroblast growth factor binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS19 itself. We selected most functions RPS19 had, and list some proteins which have the same functions with RPS19. You can find most of the proteins on our site.
Function
Related Protein
Function fibroblast growth factor binding
Related Protein FIBP; RPS2; CXCL13; THBS1; TGFBR3; GLG1B; GLG1; KLB; PTPRZ1; FGFR4
Function poly(A) RNA binding
Related Protein SERBP1; SUPT6H; YTHDC2; MRPL22; YTHDF1; TCOF1; PLEC; KHDRBS3; TRMT1L; DUSP11
Function protein binding
Related Protein ZBTB43; LRRC25; DENND2D; SLIRP; ZWILCH; 2610109H07Rik; HEBP2; ARL2BP; MDH1; NMB
Function protein homodimerization activity
Related Protein ABCB10; SFTPC; PDGFRA; SLC30A8; ABCB9; KYNU; SLC26A5; CAMK2A; NUDT16; ANXA1
Function protein kinase binding
Related Protein MSH2; SUFU; EEF2; CADPS; XBP1; SPRED2; ATG13; CDK5; TUBB3; GATA4
Function structural constituent of ribosome
Related Protein MRPL28; RPL5A; RPS28; MRPL27; MRPL18; MRPL16; RPL6; MRPL22; MRPS22; RPS7

Interacting Protein

RPS19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS19 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS19.
PIM1; VCAM1; MAGEB2; EIF1B; GH1; FGF2; NME2; VHL; ACTB; CNBP

RPS19 Related Articles

Nishiura, H; Chen, J; et al. Base of molecular mimicry between human ribosomal protein S19 dimer and human C5a anaphylatoxin. INTERNATIONAL IMMUNOPHARMACOLOGY 10:1541-1547(2010).
Badhai, J; Frojmark, AS; et al. Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency. FEBS LETTERS 583:2049-2053(2009).