rnf216
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  • Official Full Name
  • ring finger protein 216
  • Background
  • This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
  • Synonyms
  • RNF216; ring finger protein 216; E3 ubiquitin-protein ligase RNF216; TRIAD3; U7I1; UBCE7IP1; ZIN; triad domain-containing protein 3; zinc finger protein inhibiting NF-kappa-B; ubiquitin-conjugating enzyme 7-interacting protein 1
Cat.#:RNF216-14335MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNF216 Protein
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Cat.#:RNF216-2282HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNF216 293 Cell Lysate
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Involved Pathway

Rnf216 involved in several pathways and played different roles in them. We selected most pathways Rnf216 participated on our site, such as Gastric cancer network 1, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rnf216 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gastric cancer network 1
S100P; TPX2; GATS; ACTL6A; MYBL2; ESM1; LIN9; TOP2A; C21orf33; RNF216
Immune System
SIGLEC14; BST2; HBL3; RNF34; CLEC2D; CD207; TNRC5; MICA; GBP4; LTF
Innate Immune System
LY86; POLR3GLA; ART1; NLRP4B; KIR3DS1; BTR12; CR1; CHST13; DEFB4A; LAT2
Negative regulators of RIG-I/MDA5 signaling
HERC5; RNF135; CYLD; TAX1BP1; NLRC5; TAX1BP1B; PCBP2; RNF216
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
TAX1BP1; NLRC5; HERC5; PCBP2; TAX1BP1B; TANK; RNF216; RNF135
TNF-alpha/NF-kB Signaling Pathway
TXLNA; RNF216; DDX3X; LRPPRC; G3BP2; SMARCE1; MARK2; NKIRAS2; PPP1R13L; TRAIP
protein ubiquitylation
UBE2U; UEVLD; UBE2E3; RNF216; UBA5

Protein Function

Rnf216 has several biochemical functions, for example, ligase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Rnf216 itself. We selected most functions Rnf216 had, and list some proteins which have the same functions with Rnf216. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein UBE2F; RC3H2; GLULA; GATB; UBR3; PIAS4; RNF144AB; RNF13; RNF40; UHRF1
Function metal ion binding
Related Protein RYBPA; ZBTB17; ACAN; SOBP; AGAP1; STK32A; PPP3CB; KLF12B; MEP1A.2; ZDHHC24
Function protein binding
Related Protein IGFBP3; KLB; PRMT2; SIP1; MYH10; HSF1; IL6R; GRIN2C; TDG; MAPK11

Interacting Protein

Rnf216 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rnf216 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rnf216.
dinB; RNF11

Rnf216 Related Articles

Zhang, TT; Prives, C; et al. Cyclin A-CDK phosphorylation regulates MDM2 protein interactions. JOURNAL OF BIOLOGICAL CHEMISTRY 276:29702-29710(2001).