Recombinant Human RNF216 Protein (E2-F866), His tagged

• Cat.No.: RNF216-0613H
• Product Overview: Recombinant Human 6His-TEV-(GG)-RNF216(E2-F866 end) Protein was expressed in E. coli.

Specification

• Description: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: E2-F866
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: RNF216 ring finger protein 216 [ Homo sapiens (human) ]
• Official Symbol: RNF216
• Synonyms: RNF216; ring finger protein 216; E3 ubiquitin-protein ligase RNF216; TRIAD3; U7I1; UBCE7IP1; ZIN; triad domain-containing protein 3; zinc finger protein inhibiting NF-kappa-B; ubiquitin-conjugating enzyme 7-interacting protein 1
• Gene ID: 54476
• mRNA Refseq: NM_207111
• Protein Refseq: NP_996994
• MIM: 609948
• UniProt ID: Q9NWF9