• Official Full Name
  • SEC14-like 2 (S. cerevisiae)
  • Background
  • This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms
  • SEC14L2; SEC14-like 2 (S. cerevisiae); C22orf6, SEC14 (S. cerevisiae) like 2; SEC14-like protein 2; KIAA1186; KIAA1658; SPF; supernatant protein factor; TAP; Alpha tocopherol associated protein; Alpha-tocopherol-associated protein; C22orf6; hTAP; MGC65053; OTTHUMP00000198972; OTTHUMP00000198973; OTTHUMP00000198974; OTTHUMP00000199021; S14L2_HUMAN; SEC14 (S. cerevisiae) like 2; SEC14 like 2 (S. cerevisiae); SEC14 like protein 2; Squalene transfer protein; TAP1; tocopherol-associated protein
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SEC14L2 protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human SEC14L2 293 Cell Lysate

Protein Function

SEC14L2 has several biochemical functions, for example, enzyme activator activity, phospholipid binding, transferase activity, transferring alkyl or aryl (other than methyl) groups. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC14L2 itself. We selected most functions SEC14L2 had, and list some proteins which have the same functions with SEC14L2. You can find most of the proteins on our site.
Related Protein
Function enzyme activator activity
Related Protein MMP17; APOA5; GLC8; GTF3C4; DNMT3L; GM1679; PRKCD; CASP9; CTAGE5; SLX4
Function phospholipid binding
Function transferase activity, transferring alkyl or aryl (other than methyl) groups
Related Protein SEC14L2
Function transporter activity
Related Protein SLC2A3A; HIATL2; RBP4L; SLC2A15A; Csn1s2b; Slc4a2; GABRA5; RBP5; ATP6AP1; AQP1A.2
Function vitamin E binding
Related Protein TTPA; AFM; SEC14L2

Interacting Protein

SEC14L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC14L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC14L2.

SEC14L2 Related Articles

Zingg, JM; Azzi, A; et al. Induction of VEGF Expression by Alpha-Tocopherol and Alpha-Tocopheryl Phosphate via PI3K gamma/PKB and hTAP1/SEC14L2-Mediated Lipid Exchange. JOURNAL OF CELLULAR BIOCHEMISTRY 116:398-407(2015).
Zingg, JM; Libinaki, R; et al. Modulation of Phosphorylation of Tocopherol and Phosphatidylinositol by hTAP1/SEC14L2-Mediated Lipid Exchange. PLOS ONE 9:-(2014).