sema4a
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  • Official Full Name
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
  • Background
  • This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; semaphorin-4A; sema B; semaphorin-B; semaphorin 4A; SemB; Semab; AI132332
Cat.#:SEMA4A-594HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA4A Protein, MYC/DDK-tagged
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Cat.#:SEMA4A-3925HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA4A, Fc tagged
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Cat.#:SEMA4A-3926HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA4A, His tagged
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Cat.#:SEMA4A-14866MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sema4a protein, His-tagged
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Cat.#:Sema4a-14867MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Sema4a protein, Fc-tagged
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Cat.#:Sema4a-4001MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Sema4a, HIgG1 Fc-tagged
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Cat.#:SEMA4A-1979HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA4A cell lysate
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Cat.#:SEMA4A-2066HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA4A cell lysate
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Involved Pathway

SEMA4A involved in several pathways and played different roles in them. We selected most pathways SEMA4A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
COL4A4; SHB; GFRA2; EFNA1; AP2A1; UNC5D; SEMA6C; RND1L; RHOAE; FGF8B

Protein Function

SEMA4A has several biochemical functions, for example, chemorepellent activity, NOT neuropilin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA4A itself. We selected most functions SEMA4A had, and list some proteins which have the same functions with SEMA4A. You can find most of the proteins on our site.
Function
Related Protein
Function chemorepellent activity
Related Protein SEMA3E; SEMA3G; SEMA6D; SEMA5B; SEMA3AB; SEMA3C; SEMA3GA; SEMA6E; Sema3f; SEMA5A
Function NOT neuropilin binding
Related Protein SEMA4D; SEMA4C; SEMA4B; SEMA4BA; SEMA4A
Function protein binding
Related Protein RIPK1; EPS8L1; OTUB1; AGBL1; MLLT10; TXNDC11; DSCC1; SP1; KAT7; NEU2
Function semaphorin receptor binding
Related Protein SEMA4D; SEMA3C; SEMA3GB; SEMA6B; SEMA3AA; SEMA5A; SEMA6A; SEMA3BL; SEMA3B; SEMA3GA

Interacting Protein

SEMA4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA4A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA4A.
PLXND1; PLXNB2; PLXNB1; PLXNB3; DDX54

SEMA4A Related Articles

Ishii, H; Kubo, T; et al. Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402:168-172(2010).
Yukawa, K; Tanaka, T; et al. Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 16:115-118(2005).