serpind1
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  • Official Full Name
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1
  • Background
  • The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.
  • Synonyms
  • SERPIND1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1; HCF2, serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; heparin cofactor 2; D22S673; HC II; HC2; heparin cofactor II; HLS2; serpin D1; leuserpin 2
Cat.#:SERPIND1-2599HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPIND1, His-tagged
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Cat.#:SERPIND1-3157HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPIND1, His-tagged
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Cat.#:SERPIND1-367HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPIND1 Protein, His-tagged
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Cat.#:Serpind1-2310MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Serpind1, His tagged
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Cat.#:Serpind1-368MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Serpind1 Protein, GST-tagged
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Cat.#:Serpind1-369RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Serpind1 Protein, His-tagged
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Cat.#:SERPIND1-5343RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SERPIND1 Protein
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Cat.#:SERPIND1-4154RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SERPIND1 Protein, His-tagged
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Cat.#:SERPIND1-9669ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SERPIND1
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Cat.#:SERPIND1-12HTag:N/A
Source (Host):Species:Human
Product nameNative Human Heparin Cofactor II
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Cat.#:SERPIND1-2854HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPIND1 cell lysate
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Cat.#:SERPIND1-2554MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SERPIND1 cell lysate
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Involved Pathway

Serpind1 involved in several pathways and played different roles in them. We selected most pathways Serpind1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Serpind1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
C1QC; F5; SERPIND1; F10; F3; PLG; F13A1; C8A; PROS1; C9

Protein Function

Serpind1 has several biochemical functions, for example, endopeptidase inhibitor activity, heparin binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Serpind1 itself. We selected most functions Serpind1 had, and list some proteins which have the same functions with Serpind1. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase inhibitor activity
Related Protein C3B.2; CST3; LPA; STFA1; C3A.3; PROS1; C4A; CST14B.1; RECK; SERPIND1
Function heparin binding
Related Protein LXN; LIPC; MSTN; ECM2; RSPO2; PCOLCE2; CTGFB; ZNF207; CTGFA; CLEC3B
Function serine-type endopeptidase inhibitor activity
Related Protein SERPINA12; SPINK10; ITIH5; SPINT4; SPINK1; SERPINI2; PI3; WFDC5; SPINK8; SERPINA10

Interacting Protein

Serpind1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Serpind1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Serpind1.
p29991-pro_0000037940; p29991-pro_0000037946; p29991-pro_0000308465; q99ib8-pro_0000045599; d-mannose; IGHG1; IGHA1; TF

Serpind1 Related Articles

Kumar, A; Bhandari, A; et al. Genetic variants and evolutionary analyses of heparin cofactor II. IMMUNOBIOLOGY 219:713-728(2014).
Charles, JF; Coury, F; et al. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. BONE 51:902-912(2012).