This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
SETBP1; SET binding protein 1; SET-binding protein; KIAA0437; SEB; SETBP 1
SETBP1 has several biochemical functions, for example, DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETBP1 itself. We selected most functions SETBP1 had, and list some proteins which have the same functions with SETBP1. You can find most of the proteins on our site.
Function DNA binding
Related Protein WDHD1; ZNF785; ZFP521; FOXL2; SOX21A; TCEB3B; LYL1; NR2F6A; HNF1BB; FOXP2
Function protein binding
Related Protein MCC; ZBP1; RHOV; CD200R3; MEF2A; SERPINA1A; EED; CLIC5; PRH2; RIPK2
SETBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETBP1.