sf3a3
Share
  • Official Full Name
  • splicing factor 3a, subunit 3, 60kDa
  • Background
  • This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.
  • Synonyms
  • SF3A3; splicing factor 3a, subunit 3, 60kDa; splicing factor 3a, subunit 3, 60kD; splicing factor 3A subunit 3; PRP9; PRPF9; SAP61; SF3a60; Pre mRNA splicing factor SF3a (60kD); Pre mRNA splicing factor SF3a; PRP 9; PRPF 9; SAP 61; Spliceosome associated protein 61; Splicing factor 3a subunit 3 60kDa; OTTHUMP00000004730; spliceosome-associated protein 61; pre-mRNA splicing factor SF3a (60kD)
Cat.#:SF3A3-2612HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SF3A3, GST-tagged
+Inquiry
Cat.#:SF3A3-30078THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SF3A3, His-tagged
+Inquiry
Cat.#:SF3A3-1235ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SF3A3
+Inquiry
Cat.#:SF3A3-1919HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SF3A3 293 Cell Lysate
+Inquiry

Involved Pathway

SF3A3 involved in several pathways and played different roles in them. We selected most pathways SF3A3 participated on our site, such as Diurnally regulated genes with circadian orthologs, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Diurnally regulated genes with circadian orthologs
QK; CRY1; UCP3; ZFR; GFRA1; NR1D2; KLF9; STBD1; G0S2; RBPMS
Gene Expression
CLP1; YBX1; ZNF18; ZNF180; ZNF664; HIPK1; ADAT2; EIF5; NR0B2A; ZNF624
Processing of Capped Intron-Containing Pre-mRNA
HNRNPD; HNRNPL2; SF3A1; HNRNPF; SNRNP48; CCAR1; PRPF8; RNPC3; SF3B4; CSTF2
Spliceosome
SNRPB; SF3B6; USP39; PRPF19; SRSF1A; SNRPE; HSPA2; DDX46; NCBP2; LSM4
mRNA Splicing
HNRPL; DNAJC8; HNRNPD; PTBP1; SF3B2; HNRNPUL1; HNRNPF; HNRNPR; SF3B4; PTBP1B
mRNA Splicing - Major Pathway
CCAR1; DNAJC8; PCBP2; HNRNPR; HNRNPF; SFRS3A; HNRNPA0L; HNRNPH1L; PTBP1B; HNRNPA0B
mRNA processing
HNRNPA2B1; SFPQ; SPOP; CLK4; HNRNPD; PRMT2; OASL2; RBM5; ZFP346; RBM39

Protein Function

SF3A3 has several biochemical functions, for example, poly(A) RNA binding, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3A3 itself. We selected most functions SF3A3 had, and list some proteins which have the same functions with SF3A3. You can find most of the proteins on our site.
Function
Related Protein
Function poly(A) RNA binding
Related Protein LSM4; ZCCHC24; NOLC1; RALY; RBM22; HDAC2; SCG3; DNM1; GNL3; SF3A3
Function protein binding
Related Protein DRD1; ATPAF1; ERN1; BACH1; DBNDD2; UBE2V1; MED24; GHITM; PPP2R3C; DNMBP
Function zinc ion binding
Related Protein BTR22; CAR5A; ZDHHC4; FTR67; LIMS1; NSMCE2; ABLIM1; ADAM10; RNF175; TRIM35-30

Interacting Protein

SF3A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3A3.
TADA2A; TRIM69; ORF; ZNF212; HSPB1; SF3A1; WBP4; SMNDC1; FOS; CHM