sgk1
Share
  • Official Full Name
  • serum/glucocorticoid regulated kinase 1
  • Background
  • This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Synonyms
  • SGK1; serum/glucocorticoid regulated kinase 1; serum/glucocorticoid regulated kinase , SGK; serine/threonine-protein kinase Sgk1; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1; SGK
Cat.#:SGK1-1080HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SGK1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:SGK1-428HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SGK1, GST-tagged, Active
+Inquiry
Cat.#:SGK1-644HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SGK1, GST-tagged
+Inquiry
Cat.#:SGK1-30970THTag:
Source (Host):Species:Human
Product nameRecombinant Human SGK1
+Inquiry
Cat.#:SGK1-3920HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SGK1 protein, His-tagged
+Inquiry
Cat.#:SGK1-4993HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SGK1 protein, GST-tagged
+Inquiry
Cat.#:SGK1-577HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human SGK1, GST-tagged
+Inquiry
Cat.#:SGK1-755HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SGK1, T7-tagged
+Inquiry
Cat.#:Sgk1-145MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sgk1 protein, His-tagged
+Inquiry
Cat.#:SGK1-15035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SGK1 Protein
+Inquiry
Cat.#:SGK1-6046CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SGK1
+Inquiry
Cat.#:SGK1-9896ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SGK1
+Inquiry
Cat.#:SGK1-1346HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human Serum/Glucocorticoid Regulated Kinase 1, His-tagged
+Inquiry

Involved Pathway

SGK1 involved in several pathways and played different roles in them. We selected most pathways SGK1 participated on our site, such as FoxO signaling pathway, PIK-Akt signaling pathway, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGK1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PIK3R3A; AGAP2; FOXO6; PIK3CD; Fasl; GRM1; CCNB1; NLK; MAPK10; FOXO3B
PIK-Akt signaling pathway
IFNA17; IGF1; Itga10&Itgb1; FGF11; MAPK3; CREB3L1; ATF4; PPP2R5A; IFNA4; FGF19
Aldosterone-regulated sodium reabsorption
IRS1; NR3C2; PIK3CD; SCNN1G; ATP1A1; SLC9A3R2; ALPHA-ENAC; PIK3CB; KRAS; ATP1A4

Protein Function

SGK1 has several biochemical functions, for example, ATP binding, calcium channel regulator activity, chloride channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGK1 itself. We selected most functions SGK1 had, and list some proteins which have the same functions with SGK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2C; UBE2KB; EPHA8; CIT; NAIP1; PKM; LIG4; NRK; ABCC6; ACVRL1
Function calcium channel regulator activity
Related Protein GRM6A; NRXN1; NRXN2; GRM7; TMEM110; CACNA2D3; GRM2; HPCAL4; NPY2R; CACNB2
Function chloride channel regulator activity
Related Protein SGK2B; SGK2A; CHRNA7; SGK1; BSND; SLC9A3R1; SGK3; SGK2
Function potassium channel regulator activity
Related Protein KCNMB1; ARPP19; KCNS3; DLG1; SGK2A; ANK2; SUMO1; SGK3; KCNE2; DRD2
Function protein binding
Related Protein TSSK6; ZNF232; FBXO46; EDA; NOL12; FST; RTN4A; ZFP488; RAD51L3; LZTS2
Function protein serine/threonine kinase activity
Related Protein MAP4K1; TSSK4; MKNK2; AKT3; MAST2; NUAK1; FAM20C; PAK1; TNIK; ADCK4
Function protein serine/threonine/tyrosine kinase activity
Related Protein DYRK3; DYRK1A; CLK2; CLK1; DYRK1AA; DSTYK; RPS6KA1; CLK3; TESK2; TTK
Function sodium channel regulator activity
Related Protein FXYD5; SCN3B; FXYD7; SGK2; GPD1L; SGK3; SGK1; FGF13; FXYD1; FGF12

Interacting Protein

SGK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGK1.
CREB1; RABAC1; PDPK1; GADD45G; MAPT; IKBKG; Tcr-alpha; 13514813; PPIAL4D; EIF3F; PFAS; CS; CBR3; LETM1

SGK1 Related Articles

Qadri, SM; Su, Y; et al. Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal. CARDIOVASCULAR DIABETOLOGY 13:-(2014).
Heller, BA; Ghidinelli, M; et al. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. JOURNAL OF CELL BIOLOGY 204:1219-1236(2014).