SH2B2 Protein, SH2B adaptor protein 2

SH2B2

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SH2B2

Official Full Name SH2B adaptor protein 2
Background APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B. APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor. Tyrosine phosphorylation of APS provid
Synonyms SH2B2; SH2B adaptor protein 2; SH2B adapter protein 2; adaptor protein with pleckstrin homology and src; APS; SH2 and PH domain-containing adapter protein APS; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleck
    • Species :
    • Guinea pig
    • Human
    • Mouse
    • Rat
    • Source :
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APS-730H Recombinant Human APS protein, GST-tagged Wheat Germ GST
    Human SH2B2-1341H Recombinant Human SH2B2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse SH2B2-15052M Recombinant Mouse SH2B2 Protein Mammalian Cell His
    Rat SH2B2-5372R Recombinant Rat SH2B2 Protein Mammalian Cell His
    Guinea pig Sh2b2-3307C Recombinant Cavia porcellus (Guinea pig) Sh2b2, His-tagged E.Coli or Yeast His

    SH2B2 involved in several pathways and played different roles in them. We selected most pathways SH2B2 participated on our site, such as Neurotrophin signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neurotrophin signaling pathway CDC42; MAPK3; MAPK10; ZFP110; TP73; PIK3R3; FOXO3; MAP2K7; PSEN2; SHC2
    Insulin signaling pathway FASN; CBLC; SOCS1; PPARGC1A; GSK3B; AKT1; CALM3; PIK3R3A; MAP2K1; HRAS

    SH2B2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity, SH3/SH2 adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B2 itself. We selected most functions SH2B2 had, and list some proteins which have the same functions with SH2B2. You can find most of the proteins on our site.

    Function Related Protein
    JAK pathway signal transduction adaptor activity SH2B2; SOCS2
    SH3/SH2 adaptor activity SLA; HSH2D; SH3BGR; GRB10; IRS4; RUSC1; SKAP1; KHDRBS1; SOCS2; GRAP
    identical protein binding VWF; EDC3; STAT6; ACPP; NME1; CLDN20; GDF5; DDX58; RIPK1; LDHA
    protein binding NPY1R; STK39; DNAI2; PDCL; BAP1; MAPKAPK5; CCDC117; TELO2; SIRT1; TMEM86B
    signal transducer activity STAT1B; TAS2R120; OLFCD2; TAAR11; LPAR2A; OLFR11; STAT3; GNG11; RHOC; GNG12
    signaling adaptor activity MPP7; GNB2L1; SH2B2; AFAP1L2; LDLRAP1; SH2B3; SH2B1; HOMER1
    transmembrane receptor protein tyrosine kinase adaptor activity SH2B2; STAP1; BLNK; PIK3R1; TRAT1; SHC1; IRS1; GAB2; DOK2; FRS2

    SH2B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B2.

    Fgfr3

    de Boer, YS; van Gerven, NMF; et al. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1. GASTROENTEROLOGY 147:443-+(2014).
    Perez-Garcia, A; Ambesi-Impiombato, A; et al. Genetic loss of SH2B3 in acute lymphoblastic leukemia. BLOOD 122:2425-2432(2013).

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