SH2B2

  • Official Full Name

    SH2B adaptor protein 2

  • Overview

    APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B. APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor. Tyrosine phosphorylation of APS provid

  • Synonyms

    SH2B2;SH2B adaptor protein 2;SH2B adapter protein 2;adaptor protein with pleckstrin homology and src;APS;SH2 and PH domain-containing adapter protein APS;adapter protein with pleckstrin homology and Src homology 2 domains;adaptor protein with pleck

Recombinant Proteins

  • Human
  • Mouse
  • Guinea pig
  • Rat
  • Wheat Germ
  • Mammalian Cells
  • E.Coli/Yeast
  • HEK293
  • GST
  • His
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    SH2B2 involved in several pathways and played different roles in them. We selected most pathways SH2B2 participated on our site, such as Neurotrophin signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neurotrophin signaling pathway SHC1,TP53,TRP53,PIK3CB,NFKB1,FOXO3,HRAS,NTRK2,KIDINS220,SH2B1
    Insulin signaling pathway PRKAG1,INSB,EIF4E1B,RAF1B,BAD,RAF1A,HRASA,PYGMA,INS,INPPL1A

    Protein Function

    SH2B2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity,SH3/SH2 adaptor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B2 itself. We selected most functions SH2B2 had, and list some proteins which have the same functions with SH2B2. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity IRS4,SH2D3C,NCK2,FCRL2,SH3BGR,ARHGAP4,KHDRBS1,STAM,SLA,GAB1
    transmembrane receptor protein tyrosine kinase adaptor activity SHC1,PIK3R1,STAP1,FRS2,DOK2,BLNK,IRS1,TRAT1,GAB2
    signal transducer activity PRLH2R,OLFR181,CXCR2,RGS9B,RGRB,PLCB3,IL10RA,OXTRL,GPR62,OR103-4
    signaling adaptor activity LDLRAP1,AFAP1L2,SH2B1,GNB2L1,HOMER1,MPP7,SH2B3
    JAK pathway signal transduction adaptor activity SOCS2
    identical protein binding OMG,ZNHIT6,CNTN2,AMELX,DAPK2,LECT2,MTPAP,BNIP2,VPS4B,RIPK1
    protein binding HIST1H2AM,TMEM140,POMGNT1,RNF144B,CXCL9,PRDX1,CCDC60,CSRNP2,FGF2,PA2G4

    Interacting Protein

    SH2B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B2.

    Fgfr3

    Resources

    References

    • Perez-Garcia, A; Ambesi-Impiombato, A; et al. Genetic loss of SH2B3 in acute lymphoblastic leukemia. BLOOD 122:2425-2432(2013).
    • de Boer, YS; van Gerven, NMF; et al. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1. GASTROENTEROLOGY 147:443-+(2014).

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